Consequences of hazardous dietary calcium deficiency for fattening bulls

BACKGROUND: Deficient mineral supplementation on a feedlot farm resulted in severe clinical manifestations in fattening bulls. Animals mistakenly received only 60–70% of the recommended calcium intake, while simultaneously receiving twice the amount of phosphorus recommended. Thus, the dietary Ca/P ratio was severely distorted. After approximately six months on such a diet, four fattening bulls were euthanized because of severe lameness and 15% of other animals on the farm were having clinical leg problems. Veterinary consultation revealed the mistake in mineral supplementation. METHODS: Fattening bulls were divided into three groups depending on the time of their arrival to the farm. This enabled the effect of mineral imbalance at different growth phases to be examined. After slaughtering, the bones of both front and hind limbs were macroscopically evaluated. RESULTS: Over 80% of the animals with a calcium-deficient diet had at least one severe osteoarthritic lesion. The economic impact of the calcium deficiency was statistically significant. CONCLUSION: Calcium deficiency with distorted Ca/P ratio yielded a severe outbreak of osteoarthritis in fattening bulls. Calcium deficiency caused a more serious lesions in age group 5–12 months than age group 12–18 months. Besides causing obvious economic losses osteoarthritis is also a welfare issue for feedlot animals

Association between interleukin 1 gene cluster polymorphisms and bilateral distal interphalangeal osteoarthritis.

OBJECTIVE: To examine the association of the interleukin 1 gene (IL1) cluster polymorphisms and their haplotypes with bilateral distal interphalangeal joint osteoarthritis (DIP OA). METHODS: Radiographs of both hands of 295 dentists and 248 teachers were examined and classified for the presence of OA using reference images. Bilateral DIP OA was defined by the presence of radiographic findings of grade 2 or more in at least 1 symmetrical pair of the DIP joints. We genotyped 10 single-nucleotide polymorphisms (SNP) in the IL1R1, IL1RL2, IL1A, IL1B, and IL1RN genes using polymerase chain reaction-based methods. Haplotypes were statistically reconstructed using the PHASE program. The association between the genotypes/diplotypes and bilateral DIP OA was examined with logistic regression analysis. RESULTS: Two IL1B SNP (rs1143634 and rs1143633) were associated with bilateral DIP OA. The carriers of the IL1B rs1143634 minor allele had an increased OA risk [odds ratio (OR) 1.6; 95% confidence interval (CI) 1.08-2.26] compared to the noncarriers. The association was stronger in the dentists. The distribution of the IL1B rs1143633 genotype fit a recessive mode of inheritance (OR 3.03, 95% CI 1.35-6.83, p = 0.006). Two IL1B-IL1RN extended haplotype alleles (211-1 and 121-1) were associated with bilateral DIP OA. An interaction between the IL1B rs1143634 and the IL1R1-IL1RL2 and IL1B-IL1RN extended haplotypes and occupation (increased risk of OA among dentists only) was observed. CONCLUSION: Our results provide further evidence for the role of IL1 gene cluster polymorphisms in the etiology of OA and suggest that some of these may predispose DIP joints to the effects of mechanical overload

GeenivaraOppi - Oppia ja tiedettä kasvigeenivaroista

. Viittausohje Geenivaraoppi-hankkeen sivustoon: Kirjoittaja: Verkkoartikkelin nimi. Verkkosivun nimi. Peda.net [viitattu:pvm]. Saantitapa: Opetus- ja kulttuuriministeriöLuonnonvarakeskusMetsähallitusAhlmanin koulun säätiö201