Superconducting MoSi nanowires

We have fabricated disordered superconducting nanowires of molybdenium silicide. A molybdenium nanowire is first deposited on top of silicon, and the alloy is formed by rapid thermal annealing. The method allows tuning of the crystal growth to optimise, e.g., the resistivity of the alloy for potential applications in quantum phase slip devices and superconducting nanowire single-photon detectors. The wires have effective diameters from 42 to 79 nm, enabling the observation of crossover from conventional superconductivity to regimes affected by thermal and quantum fluctuations. In the smallest diameter wire and at temperatures well below the superconducting critical temperature, we observe residual resistance and negative magnetoresistance, which can be considered as fingerprints of quantum phase slips

Covid-19 voices in finnish news media in the global context: A Comparative Study of News Media’s Roles in Pandemic Communications and Public Perceptions across Six Countries

This project investigated issues pertaining to COVID-19 related communications by different social actors, such as governments, news media, health authorities, experts, business organizations, and their impact on the general public’s attitudes and behaviours. It sheds some light into the news media’s role during pandemics, thus exploring the extent by which news media contributed to specific understandings of the COVID-19 pandemic by their journalistic choices of issues, tone, and crisis narratives. This project is comparative in nature, including data on public perceptions across six countries (Australia, Finland, Italy, South Korea, Sweden, and USA) and news media analyses of two countries’ main news outlets (Finland and Sweden)

Leveraging NLP for crisis communication management: A case study of news media analysis of the COVID‐19 pandemic in two Nordic countries

The news media plays a vital role in influencing public perceptions about topics, issues and crises. They also act as important intermediaries between organizations and public, enabling organizations to shape how people think about crisis topics and actors. Monitoring news coverage and assessing the news media's agenda‐setting role in a crisis can help organizations respond more effectively to emerging situations. When crises are prolonged and affect many countries, media analysis can become a tedious task for crisis managers. This study demonstrates how natural language processing (NLP) methods can be utilized in news media analysis of crisis situations, such as an extended cross‐national pandemic. Specifically, it demonstrates the possibilities of using NLP to identify and compare the salience of diverse crisis topics and how the media treat these topics and crisis actors (first‐ and second‐level agenda‐setting) across countries, news outlets, and time. The COVID‐19 pandemic serves as an illustrative case study to showcase the application of NLP techniques to provide insights into public perceptions of a major health crisis shaped by the news media in two Nordic countries (Finland and Sweden). Findings show the suitability of NLP methods to detect nuanced differences in news media coverage and offer relevant knowledge of how public perceptions and responsibility attribution fluctuate across time and countries

Pihattotutkimus 1976...1978

Erip.: Koneviesti ; 1979, 8...13

Insulin dysregulation in a population of Finnhorses and associated phenotypic markers of obesity

Background Obesity and insulin dysregulation (ID) predispose horses to laminitis. Determination of management practices or phenotypic markers associated with ID may benefit animal welfare. Objectives Determine ID status of a population of Finnhorses using an oral sugar test (OST) and compare phenotypes and management factors between ID and non-ID Finnhorses. Animals One hundred twenty-eight purebred Finnhorses >= 3 years of age. Methods Owners were recruited using an online questionnaire regarding signalment, history, feeding, and exercise of their horses. Selected contributing stables within a predefined area were visited. Phenotypic markers of obesity and the weight of each horse were recorded. After fasting overnight, horses received 0.45 mL/kg corn syrup PO. Serum samples before and at 60 and 90 minutes after syrup administration were analyzed for insulin by chemiluminescent assay. Horses met ID criteria if insulin concentrations were >= 33 mu IU/mL at T0, >= 66 mu IU/mL at T60 or T90 or some combination thereof. Associations between phenotypic markers, feeding and exercise variables, and ID were examined using mixed effects logistic regression modeling. Results Several phenotypic markers of obesity were significant on univariable analysis but in the final multivariable model, only obesity (body condition score >= 8) was associated with ID (P= .04). Over half of the horses (60% [95% confidence interval (CI), 51%-68%]) were considered overweight or obese whereas 16% (95% CI, 10%-23%) were classified as having ID. Conclusions and Clinical Importance Because obesity is associated with ID in cold-blooded type horses, objective monitoring of phenotypic markers by owners may be beneficial for health outcomes.Peer reviewe

Effects of vatinoxan on cardiorespiratory function and gastrointestinal motility during constant-rate medetomidine infusion in standing horses

Background: Medetomidine suppresses cardiovascular function and reduces gastrointestinal motility in horses mainly through peripheral α2‐adrenoceptors. Vatinoxan, a peripheral α2‐antagonist, has been shown experimentally to alleviate the adverse effects of some α2‐agonists in horses. However, vatinoxan has not been investigated during constant‐rate infusion (CRI) of medetomidine in standing horses.Objectives: To evaluate effects of vatinoxan on cardiovascular function, gastrointestinal motility and on sedation level during CRI of medetomidine.Study design: Experimental, randomised, blinded, cross‐over study.Methods: Six healthy horses were given medetomidine hydrochloride, 7 μg/kg i.v., without (MED) and with (MED+V) vatinoxan hydrochloride, 140 μg/kg i.v., followed by CRI of medetomidine at 3.5 μg/kg/h for 60 min. Cardiorespiratory variables were recorded and borborygmi and sedation levels were scored for 120 min. Plasma drug concentrations were measured. The data were analysed using repeated measures ANCOVA and paired t‐tests as appropriate.Results: Initially heart rate (HR) was significantly lower and mean arterial blood pressure (MAP) significantly higher with MED compared with MED+V. For example at 10 min HR (mean ± s.d.) was 26 ± 2 and 31 ± 5 beats/minute (P = 0.04) and MAP 129 ± 15 and 103 ± 13 mmHg (PMain limitations: Experimental study with healthy, unstimulated animals.Conclusions: Vatinoxan administered i.v. with a loading dose of medetomidine improved cardiovascular function and gastrointestinal motility during medetomidine CRI in healthy horses. Sedation was slightly yet significantly reduced during the first 20 min.</p

Muscle fibre type distribution of the thoracolumbar and hindlimb regions of horses: relating fibre type and functional role

Peer reviewe

Effects of vatinoxan on cardiorespiratory function, fecal output and plasma drug concentrations in horses anesthetized with isoflurane and infusion of medetomidine

A constant rate infusion (CRI) of medetomidine is used to balance equine inhalation anesthesia, but its cardiovascular side effects are a concern. This experimental crossover study aimed to evaluate the effects of vatinoxan (a peripheral α2-adrenoceptor antagonist) on cardiorespiratory and gastrointestinal function in anesthetized healthy horses. Six horses received medetomidine hydrochloride 7 μg/kg IV alone (MED) or with vatinoxan hydrochloride 140 μg/kg IV (MED + V). Anesthesia was induced with midazolam and ketamine and maintained with isoflurane and medetomidine CRI for 60 min. Heart rate, carotid and pulmonary arterial pressures, central venous pressure, cardiac output and arterial and mixed venous blood gases were measured. Selected cardiopulmonary parameters were calculated. Plasma drug concentrations were determined. Fecal output was measured over 24 h. For statistical comparisons, repeated measures analysis of covariance and paired t-tests were applied.Heart rate decreased slightly from baseline in the MED group. Arterial blood pressures decreased with both treatments, but significantly more dobutamine was needed to maintain normotension with MED + V (P = 0.018). Cardiac index (CI) and oxygen delivery index (DO2I) decreased significantly more with MED, with the largest difference observed at 20 min: CI was 39 ± 2 and 73 ± 18 (P = 0.009) and DO2I 7.4 ± 1.2 and 15.3 ± 4.8 (P = 0.014) mL/min/kg with MED and MED + V, respectively. Fecal output or plasma concentrations of dexmedetomidine did not differ between the treatments. In conclusion, premedication with vatinoxan induced hypotension, thus its use in anesthetized horses warrants further studies. Even though heart rate and arterial blood pressures remained clinically acceptable with MED, cardiac performance and oxygen delivery were lower than with MED + V.</p