COMPARISON OF LATERALIZATION THYROPLASTY AND LASER CORD WEDGE RESECTION IN TERMS OF VOICE QUALITY IN PATIENTS WITH BILATERAL ABDUCTOR VOCAL CORD PARALYSIS

AbstractBackground/Aims: It was aimed to compare lateralization thyroplasty with laser cord wedge resection in terms of postoperative voice analysis, duration of hospital stay, tracheotomy rate, and decannulation time in patients with bilateral abductor vocal cord paralysis. Methods: A total of 37 patients who presented to our department with bilateral abductor vocal cord paralysis between February 2005 and February 2009 were enrolled in this prospective study. External arytenoid lateralization (lateralization thyroplasty) was randomly performed in 22 patients and laser posterior cordotomy was performed in 15 patients. Fifteen healthy volunteers were assigned to the control group. Postoperative 6th month maximum phonation time (MPT), S/Z ratio, and the results of objective voice analysis [mean frequency perturbation (jitter), mean amplitude perturbation (shimmer), mean fundamental frequency (fo), and NHR (noise to harmonic ratio)] were compared between the two groups and the control group. Decannulation time, patient tracheotomy status, and duration of hospital stay were also recorded.Results: The mean postoperative MPT decreased but S/Z ratio increased in both patient groups compared to the control group. The mean MPT was shorter in the external arytenoid lateralization group versus the laser posterior cordotomy group (p= 0.011). There was no statistically significant difference between the external arytenoid lateralization and laser posterior cordotomy groups in terms of mean S/Z ratio (p= 0.306). It was observed that jitter, shimmer, and NHR values were increased, i.e. voice quality impaired, in both patient groups. Jitter (p= 0.004), shimmer (p<0.001), and NHR (p= 0.052) values were significantly increased in the laser posterior cordotomy group as compared with the external arytenoid lateralization group. No statistically significant difference was found between the external arytenoid lateralization group and the laser posterior cordotomy group in terms of the mean postoperative f(o) (p= 0.417), as well as for decannulation time (p= 0.076) and duration of hospital stay (p= 2.30).Conclusions: External arytenoid lateralization is a more preferable technique than laser posterior cordotomy because it preserves mucosal integrity and cord mass, which results in better voice quality

The protective effect of coumaric acid against cisplatin-induced ototoxicity in rats

Cis-diammineedichloroplatinum (cisplatin) is a chemotherapeutic agent used for the treatment of several types of cancer. However, severe side-effects such as ototoxicity, nephrotoxicity and neurotoxicity restrict its use. p-Coumaric acid (PCA) is a phenol class compound obtained from various plants in nature such as grape, carrot and tomato and from beverages such as tea and beer. It was shown to have antioxidant and free radical scavenging, anti-inflammatory and neuroprotective effects. The purpose of this study was to perform a biochemical and histopathological evaluation of the protective efficacy of PCA in ototoxicity induced with cisplatin in rats. To the best of our knowledge, no previous research has investigated the protective effect of PCA against cisplatin-induced ototoxicity. 28 Wistar rats were used. The animals were randomly divided into four groups of seven members each. No drug was administered to the rats in the control group, while the cisplatin group received a single intraperitoneal dose of 10 mg/kg cisplatin. PCA was administered to the PCA group rats by the intraperitoneal route for three days at a dose of 100 mg/kg. In the cisplatin+PCA group, intraperitoneal PCA at 100 mg/kg was administered one hour after injection of 10 mg/kg intraperitoneal cisplatin for three consecutive days. Rats were sacrificed 24 h after the final drug administration. The cochlear tissues were removed and MDA levels, GPx and SOD activities were measured to evaluate the oxidative stress status and histopathological evaluation was performed to reveal cochlear damage. The results showed that PCA protects the cochlea from ototoxic effect of cisplatin. PCA is a reliable agent that provides significant biochemical and histopathological protection against cisplatin-induced ototoxicity in rats. [Med-Science 2018; 7(2.000): 373-77

The effect of ferulic acid against cisplatin-induced ototoxicit

Ototoxicity refers to cellular damage or functional disorder developing in the inner ear in association with any therapeutic agent or chemical substance. Cisplatin, one of these agents capable of causing ototoxicity, is a chemotherapeutic used in several malignancies. Ferulic acid (FA) is a phenolic acid with known anti-oxidative and anti-inflammatory properties. The purpose of this study was to perform a biochemical and histopathological investigation of the protective efficacy of FA against cisplatin-induced ototoxicity in rats. Twenty-four Wistar rats were used in this study. Animals were randomly assigned into four groups of six rats each. Rats in the control group received intraperitoneal injection of 1 ml salin for four consecutive days. Rats in the cisplatin group received a single intraperitoneal administration of 10 mg/kg cisplatin. Rats in the FA group received intraperitoneal FA at 100 mg/kg for four days, and rats in the cisplatin+FA group received intraperitoneal FA at 100 mg/kg 1 h after administration of intraperitoneal cisplatin at 10 mg/kg, this procedure being performed for four consecutive days. Rats were sacrificed 24 h after the final drug administration. Cochlear tissues were removed for biochemical and histopathological analysis. MDA levels were significantly higher in cochlear tissues of the rats receiving cisplatin compared to the control group. MDA levels in rats receiving cisplatin and treated with FA were significantly lower than those in the cisplatin group. Activities of SOD and GPx decreased significantly in the cochleas of rats administered cisplatin compared to the control group. Both SOD and GPx activities were significantly higher in rats administered FA and cisplatin in combination compared to the cisplatin only. Histopathological evaluation of cochleas of the rats revealed significant protection of FA against cisplatin induced ototoxicity. This study, the first in the literature, shows that FA exhibits a protective effect against cisplatin-induced ototoxicity. [Med-Science 2018; 7(3.000): 528-31