Colostrum immunoglobulins and oxidative capacity may be affected by infant sex and maternal age and parity

Conclusion: In conclusion, sex-based hormonal changes in mothers during pregnancy may be associated with the different colostral immunoglobulin levels for male and female infants

The effects of oral Ginkgo biloba supplementation on radiation-induced oxidative injury in the lens of rat

Background: The aim of this study was to evaluate the antioxidant role of Ginkgo biloba (GB) against radiation-induced cataract in the rat lens after total cranial irradiation with a single 5 Gray (Gy) dose of gamma irradiation. Materials and Methods: Twenty-four Sprague-Dawley rats were used for the experiment. The rats were randomly divided into three equal groups. Group 1 did not receive GB or irradiation (control group) but received 1-ml saline orally plus sham-irradiation. Group 2 received total cranium 5 Gy of gamma irradiation as a single dose (IR group) plus 1-ml saline orally. Group 3 received total cranium irradiation plus 40 mg/kg/day GBE (IR plus GBE group). Biochemical parameters measured in murine lenses were carried out using spectrophotometric techniques. Results: Lens total (enzymatic plus non-enzymatic) superoxide scavenger activity (TSSA), non-enzymatic superoxide scavenger activity (NSSA), glutathione reductase (GRD), and glutathione-S- transferase (GST) activities significantly increased in the IR plus GBE groups when compared with the IR group. However, TSSA, GRD and GST activities were significantly lower in the IR group when compared with the control group. Lens xanthine oxidase (XO) activity in the IR group significantly increased compared to that of both the control and IR plus GBE groups. Conclusion: GBE has clear antioxidant properties and is likely to be a valuable drug for protection against gamma-irradiation and/or be used as an antioxidant against oxidative stress

The effect of training about environmental toxicant Bisphenol-A exposure in pregnancy on maternal urine Bisphenol-A level

Purpose: Bisphenol A (BPA) is an environmental toxin, clearly capable of initiating epigenetic modifications, leading to the development of numerous human illnesses such as metabolic, reproductive, and behavioural abnormalities. It also causes oxidative stress, which has been shown to be alleviated by selenium supplementation. The purpose of this study was to determine the effect of training of BPA exposure during pregnancy on urine BPA levels. Methods: This research enrolled 30 pregnant women who were in their first trimester and were free of chronic illness. Women were asked questions on their sociodemographic features, anthropometric measures, obstetric characteristics, BPA awareness level, BPA exposure and the Health Practices in Pregnancy Scale as a Pre-test and Post-Test. The initial urine samples were taken from women in their first trimester and stored in BPA-free bags. Then, training was delivered to encourage BPA exposure reduction and maternal health awareness. First-trimester face-to-face instruction and brochure distribution were followed by refresher, reminder, and follow-up trainings during the second and third trimesters. Urine samples from women in their second and third trimesters were obtained again. The levels of BPA in urine were measured using the liquid chromatography-mass spectrometry on 90 samples. Each person's urine concentration differs, thus the creatinine level in all samples was also calculated and compared to the BPA content, and the results were evaluated. Results: Our study shown that BPA exposure may be lowered by training. It has been demonstrated that reducing BPA exposure and increasing knowledge can result in an improvement in health status. Additionally, it has been demonstrated that trainings greatly minimize exposure-causing behaviours. Conclusion: It was discovered that while the duration of a single training does not make a meaningful effect, the continuing of reminder trainings did make a substantial difference in the urine BPA level

The effect of different anti-inflammatory treatment strategies on process of atherosclerosis in ankylosing spondylitis patients

Our aim in this study was to examine the effects of different anti-inflammatory treatment strategies on the process of atherosclerosis, which is an important cause of mortality in ankylosing spondylitis (AS) patients, by examining the possible effect of treatments on inflammation, lipid profile and oxidative stress parameters in patients with AS

Effectiveness of Palosuran in Bleomycin-Induced Experimental Scleroderma

Systemic sclerosis (SSc) is a disease characterized by skin and internal organ involvement. There is progressive accumulation of extracellular matrix components in the skin and involved organs. Tissue fibrosis is the prominent reason for mortality, and still, there is no satisfactory treatment. The aim of this study was to evaluate the effects of urotensin-II (U-II) antagonist palosuran in an animal model of scleroderma. We also planned to measure U-II, endothelin-1 (ET-1), and transforming growth factor-beta 1 (TGF-beta 1) levels, as well as the association of these levels with dermal thickness. Twenty-four male mice were included in this study and they were divided into three groups-group 1: control group, group 2: fibrosis group, and group 3: fibrosis + palosuran treatment group. Fibrosis + palosuran treatment in group 3 reduced ET-1, U-II, and TGF-beta 1 levels. In total, the diminished values were statistically significant in the ET-1 and TGF-beta 1 levels (p 0.05). It is believed that U-II is an important mediator in SSc, and its antagonism with palosuran could be a new treatment choice in SSc

The role of hepcidin and its related genes (BMP6, GDF-15, and HJV) in rats exposed to ischemia and reperfusion

Conclusion: Hepcidin and BMP6, HJV, and GDF-15 should be taken into account when investigating the process of I/R