Terra d’acque: il progetto ambientale del Parco del Ticino piemontese

The paper describes studies and researches carried out by the Department B.E.S.T. Building Environment Science and Technology of Politecnico di Milano since 2002 to sustain the writing out of the new Area Plan (Piano d’area) of the Natural Park of Ticino river in Piedmont. In particular the text points out the themes related with the systems of the resources -ecological, environmental, cultural and landscape resources- characterising the Park, the aims, the foreseen outcomes with reference to the planning of environment, territory and landscape of the area, considering the major methodological ways followed and the formal framework of the Plan. The short introduction of the paper points out the actions still open with regards to the environmental project of the Park of Ticino river, for example: the studies for the buffer zone called also prepark area; the analysis to sustain the drawing up of specific masterplan by the Trust for the management of the Park.

Architectural technology for environmental design

The scientific field of «Architectural Technology» has long incorporated the discipline of «Environmental Design», by giving explicit visibility to already present embedded in its foundation. They represented a significant challenge and opened the path to a real restructuring of the Architecture Schools; it is further pursuing the path traced by figures such as Eduardo Vittoria, Marco Zanuso and Pierluigi Spadolini, who pointed out a precise understanding of the habitat, which is not limited to physical and formal aspects, revealing immaterial influences on the project that aim to environmen- tal and social-economical sustainability, preluding environmental governance

Typological and technological innovation for the application of hybrid systems to housing construction: between technological culture and application testing

The research tools used in the field of technology to elaborate development trend data in prefigurate terms and the undertaking of construction of planning scenarios are here applied to the evolution of housing demands and to the rapidly changing, correlated requirement framework. Thus, the development of a research that, in the first phase proposes a theoretical framework of reference for the development of building construction, aims to reduce critical issues related to actual production models. This basis has then led to the establishment of a second step in research that, instead, aims to identifying potential practical ramifications and operative opportunities to innovate both process and product

The role of Nature-Based Solutions in architectural and urban design

In 2015 the European Commission published the report Towards an EU Research and Innovation policy agenda for Nature-Based Solutions and Re-Naturing Cities. The document standardised the many research and innovation opportunities linked to the new designing, realisation and management procedures which utilise the natural component as an important tool to support urban regeneration processes capable of building resilience and developing a green economy. This essay analyses critically the new technical elements of architectural and urban design that make use of nature-based solutions. The aim is to examine their actual capability to generate/regenerate ecosystem services and circular economy processes at various levels

Strategie operative per la rigenerazione sostenibile dell’edilizia residenziale sociale

Obiettivo del cluster “Social Housing” è quello di focalizzare l’attività di ricerca di un numeroso gruppo di ricercatori dell’area della Tecnologia dell’Architettura di diverse Università italiane su un tema progettuale di grande attualità che potrebbe contribuire a qualificare e a rilanciare vaste aree del nostro Paese: la rigenerazione urbana ed ambientale dei quartieri di edilizia residenziale pubblica realizzati tra gli anni Cinquanta e Ottanta nelle prime periferie delle principali città italiane. Si affronta in specifico il tema: Rigenerazione e qualità degli spazi - le prospettive di processo e di intervento, nella prospettiva di di definire linee guida e best practices per ERP e Social Housing attraverso pool di soluzioni innovative e operative in termini complessi di qualità architettonica, utilizzo di energia, prestazioni ambientali, sicurezza, efficienza economica e inclusione sociale

Lopinavir/Ritonavir and Darunavir/Cobicistat in Hospitalized COVID-19 Patients: Findings From the Multicenter Italian CORIST Study

Background: Protease inhibitors have been considered as possible therapeutic agents for COVID-19 patients. Objectives: To describe the association between lopinavir/ritonavir (LPV/r) or darunavir/cobicistat (DRV/c) use and in-hospital mortality in COVID-19 patients. Study Design: Multicenter observational study of COVID-19 patients admitted in 33 Italian hospitals. Medications, preexisting conditions, clinical measures, and outcomes were extracted from medical records. Patients were retrospectively divided in three groups, according to use of LPV/r, DRV/c or none of them. Primary outcome in a time-to event analysis was death. We used Cox proportional-hazards models with inverse probability of treatment weighting by multinomial propensity scores. Results: Out of 3,451 patients, 33.3% LPV/r and 13.9% received DRV/c. Patients receiving LPV/r or DRV/c were more likely younger, men, had higher C-reactive protein levels while less likely had hypertension, cardiovascular, pulmonary or kidney disease. After adjustment for propensity scores, LPV/r use was not associated with mortality (HR = 0.94, 95% CI 0.78 to 1.13), whereas treatment with DRV/c was associated with a higher death risk (HR = 1.89, 1.53 to 2.34, E-value = 2.43). This increased risk was more marked in women, in elderly, in patients with higher severity of COVID-19 and in patients receiving other COVID-19 drugs. Conclusions: In a large cohort of Italian patients hospitalized for COVID-19 in a real-life setting, the use of LPV/r treatment did not change death rate, while DRV/c was associated with increased mortality. Within the limits of an observational study, these data do not support the use of LPV/r or DRV/c in COVID-19 patients