Updated Measurement of the b baryon lifetime

sing about 4 million hadronic Z decays recorded with the Aleph detector, the lifetime of the b baryons has been measured using two independent data samples. From a maximum likelihood fit to the impact parameter distribution of leptons in 1085 Lambda-lepton combinations containing a b baryon sample of 719 decays the measured b baryon lifetime is \tau = 1.18 \pm 0.08(stat) \pm 0.07 (syst) ps The lifetime of the Lambda_b baryon from a maximum likelihood fit to the proper time distribution of 193 Lambda_c-lepton candidates is \tau_{\Lambda_b} = 1.21^{+0.13}_{-0.12}{stat}) \pm 0.04 {syst} ps. The combined result of the two measurements yields an averaged value \tau_{\Lambda_b} = 1.19 \pm{0.0

Lymphocyte Subsets and Inflammatory Cytokines of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma

Almost all multiple myeloma (MM) cases have been demonstrated to be linked to earlier monoclonal gammopathy of undetermined significance (MGUS). Nevertheless, there are no identified characteristics in the diagnosis of MGUS that have been helpful in differentiating subjects whose cancer may progress to a malignant situation. Regarding malignancy, the role of lymphocyte subsets and cytokines at the beginning of neoplastic diseases is now incontestable. In this review, we have concentrated our attention on the equilibrium between the diverse lymphocyte subsets and the cytokine system and summarized the current state of knowledge, providing an overview of the condition of the entire system in MGUS and MM. In an age where the therapy of neoplastic monoclonal gammopathies largely relies on drugs capable of acting on the immune system (immunomodulants, immunological checkpoint inhibitors, CAR-T), detailed knowledge of the the differences existing in benign and neoplastic forms of gammopathy is the main foundation for the adequate and optimal use of new drugs

Società, Economia, Territorio: le riviste scientifiche on-line a confronto

La comunicazione nel campo delle scienze socio-economiche e territoriali è attraversata da diversi anni da notevoli cambiamenti e da grande fermento. Numerose sono le iniziative editoriali nate e consolidatesi negli anni più recenti, in particolare, nel campo delle riviste on-line. Tanto da assurgere in taluni casi a un ruolo da protagonista non solo nel dibattito accademico, ma anche in quello pubblico. Taglio divulgativo, contributi attuali e incentrati su temi urgenti, open access, costruzione di reti e relazioni nazionali e internazionali, l’utilizzo e la sperimentazione di nuovi formati: in prima ipotesi, appaiono questi alcuni degli elementi chiave che spiegano la nascita e lo slancio che vivono le riviste on-line. Tuttavia, raramente i protagonisti di questo mondo si sono confrontati e raccontati, ed è stata quindi svolta una riflessione organica sulle caratteristiche delle realtà editoriali, sulle possibili fragilità e sulle sfide che in questo senso si pongono per il futuro. Con questo numero speciale, ospitato da EyesReg, rivista dell'Associazione Italiana di Scienze Regionali, l’intenzione è aprire una finestra e sviluppare una riflessione trasversale e multidisciplinare sul tema, con riferimento alla realtà italiana ma anche con significative aperture al panorama e alle esperienze europee

Motor skills in children affected by strabismus

Objectives: To compare motor skills in patients with infantile strabismus and age and sex-matched control subjects aged 5–11 years. Methods: Motor performances were assessed by the Italian version of Developmental Coordination Disorder Questionnaire 2007 (DCDQ) in children with infantile strabismus and age and sex-matched control subjects. Patients affected by specific neurological, cognitive and behavioural disorders were excluded from the study. Results: There were 43 patients included in the study, 23 in the strabismus group (14 males, 9 females, mean age 7.5 ± 2.0 years) and 24 in the control group (14 males and 10 females, mean age 7.2 ± 1.7 years. The overall DCDQ score was significantly lower in children with strabismus compared with control subjects (58.7 ± 11.3 vs. 74.2 ± 1.5; P < 0.001). Children with strabismus and no stereopsis showed a lower DCDQ score compared with those with normal stereopsis (50.8 ± 9.5 vs. 67.3 ± 4.8; P < 0.001). Conclusion: Motor skills are reduced in children with strabismus compared with control subjects. Strabismus and lack of binocular vision are factors potentially contributing to developmental coordination disorder

Comparison of flood hazard assessment criteria for pedestrians with a refined mechanics-based method

Floods have caused severe destruction and affected communities in different ways throughout history. Flood events are being exacerbated by climate change and hence it is increasingly necessary to have a more accurate understanding of various aspects of flood hazard, particularly for pedestrians. The focus of this study is therefore to investigate different criteria to assess the flood hazard for pedestrians and to propose improvements in assessing such hazards. The revised mechanics-based approach reported herein gives results based on a full physical analysis of the forces acting on a body and can be universally applied as the method can be fine-tuned for different region of the world. The results from flood hazard assessments can be used to: design evacuation plans, improve resilience of sites prone to flooding and plan more resilient future developments. Extreme flood events in the UK and documented for Boscastle (2004) and Borth (2012) were used as case studies. Two approaches were considered, including: (i) a mechanics-based approach, and (ii) an experimental-based approach, with the criteria for the stability of pedestrians in floods being compared for the criteria used by regulatory authorities in Australia, Spain, UK and USA. The results obtained in this study demonstrate that the mechanics-based methods are preferable in determining flood hazard rating assessments

BCR-ABL1 doubling-times and halving-times may predict CML response to tyrosine kinase inhibitors

In Chronic Myeloid Leukemia (CML), successful treatment requires accurate molecular monitoring to evaluate disease response and provide timely interventions for patients failing to achieve the desired outcomes. We wanted to determine whether measuring BCR-ABL1 mRNA doubling-times (DTs) could distinguish inconsequential rises in the oncogene’s expression from resistance to tyrosine kinase inhibitors (TKIs). Thus, we retrospectively examined BCR-ABL1 evolution in 305 chronic-phase CML patients receiving imatinib mesylate (IM) as a first line treatment. Patients were subdivided in two groups: those with a confirmed rise in BCR-ABL1 transcripts without MR3.0 loss and those failing IM. We found that the DTs of the former patients were significantly longer than those of patients developing IM resistance (57.80 vs. 41.45 days, p = 0.0114). Interestingly, the DT values of individuals failing second-generation (2G) TKIs after developing IM resistance were considerably shorter than those observed at the time of IM failure (27.20 vs. 41.45 days; p = 0.0035). We next wanted to establish if decreases in BCR-ABL1 transcripts would identify subjects likely to obtain deep molecular responses. We therefore analyzed the BCR-ABL1 halving-times (HTs) of a different cohort comprising 174 individuals receiving IM in first line and observed that, regardless of the time point selected for our analyses (6, 12, or 18 months), HTs were significantly shorter in subjects achieving superior molecular responses (p = 0.002 at 6 months; p < 0.001 at 12 months; p = 0.0099 at 18 months). Moreover, 50 patients receiving 2G TKIs as first line therapy and obtaining an MR3.0 (after 6 months; p = 0.003) or an MR4.0 (after 12 months; p = 0.019) displayed significantly shorter HTs than individuals lacking these molecular responses. Our findings suggest that BCR-ABL1 DTs and HTs are reliable tools to, respectively, identify subjects in MR3.0 that are failing their assigned TKI or to recognize patients likely to achieve deep molecular responses that should be considered for treatment discontinuation

Clinical implications of discordant early molecular responses in CML patients treated with imatinib

A reduction in BCR-ABL1/ABL1IS transcript levels to <10% after 3 months or <1% after 6 months of tyrosine kinase inhibitor therapy are associated with superior clinical outcomes in chronic myeloid leukemia (CML) patients. In this study, we investigated the reliability of multiple BCR-ABL1 thresholds in predicting treatment outcomes for 184 subjects diagnosed with CML and treated with standard-dose imatinib mesylate (IM). With a median follow-up of 61 months, patients with concordant BCR-ABL1/ABL1IS transcripts below the defined thresholds (10% at 3 months and 1% at 6 months) displayed significantly superior rates of event-free survival (86.1% vs. 26.6%) and deep molecular response (≥ MR4; 71.5% vs. 16.1%) compared to individuals with BCR-ABL1/ABL1IS levels above these defined thresholds. We then analyzed the outcomes of subjects displaying discordant molecular transcripts at 3-and 6-month time points. Among these patients, those with BCR-ABL1/ABL1IS values >10% at 3 months but <1% at 6 months fared significantly better than individuals with BCR-ABL1/ABL1IS <10% at 3 months but >1% at 6 months (event-free survival 68.2% vs. 32.7%; p < 0.001). Likewise, subjects with BCR-ABL1/ABL1IS at 3 months >10% but <1% at 6 months showed a higher cumulative incidence of MR4 compared to patients with BCR-ABL1/ABL1IS <10% at 3 months but >1% at 6 months (75% vs. 18.2%; p < 0.001). Finally, lower BCR-ABL1/GUSIS transcripts at diagnosis were associated with BCR-ABL1/ABL1IS values <1% at 6 months (p < 0.001). Our data suggest that when assessing early molecular responses to therapy, the 6-month BCR-ABL1/ABL1IS level displays a superior prognostic value compared to the 3-month measurement in patients with discordant oncogenic transcripts at these two pivotal time points