1,647 research outputs found
Appropriate timing of the 14 C-urea breath test to establish eradication of Helicobacter pylori infection
The aim of this study was to determine the performance characteristics of the 14 C-urea breath test (UBT) performed 2 wk after the completion of therapy for Helicobacter pylori using a 4 to 6 wk study as the gold standard. METHODS : Patients with active Helicobacter pylori infection at four medical centers received proton pump inhibitor-based triple or quadruple therapy for 10–14 days. Patients underwent the 14 C-UBT 2 and 4–6 wk after the completion of therapy. A positive test was defined as 14 CO 2 excretion of >200 dpm, a negative test as 50 but <200 dpm. Performance characteristics of the 2-wk UBT were calculated using the 4 to 6-wk result as a gold standard. RESULTS : Eighty-five patients were enrolled and 82 patients (mean ± SD age, 62 ± 15 yr; 15 women) completed the protocol. Four patients had equivocal UBT results and were excluded from the analysis. Of the 78 patients, 68 (87%) had a negative 4 to 6-wk UBT. The 2-week UBT yielded a sensitivity of 90% (95% confidence interval 72–100%), specificity of 99% (97–100%), and accuracy of 97% (93–100%). In patients with a persistently positive UBT, 14 CO 2 excretion at 2 wk was significantly lower than at 4–6 wk after therapy ( p = 0.03 ). CONCLUSIONS : A UBT performed 2 wk after therapy yielded results comparable to 4 to 6 wk testing. Further studies to evaluate the optimal time of confirmatory testing in the age of more effective proton pump inhibitor-based triple therapies are warranted.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73434/1/j.1572-0241.2000.02005.x.pd
Study of Low Energy Spin Rotons in the Fractional Quantum Hall Effect
Motivated by the discovery of extremely low energy collective modes in the
fractional quantum Hall effect (Kang, Pinczuk {\em et al.}), with energies
below the Zeeman energy, we study theoretically the spin reversed excitations
for fractional quantum Hall states at and 3/7 and find qualitatively
different behavior than for . We find that a low-energy,
charge-neutral "spin roton," associated with spin reversed excitations that
involve a change in the composite-fermion Landau level index, has energy in
reasonable agreement with experiment.Comment: Postscript figures included. Accepted in Phys. Rev. B (Rapid
Communication
A comparison of three fingerstick, whole blood antibody tests for Helicobacter pylori infection: a United States, multicenter trial
We compared three whole blood antibody tests for Helicobacter pylori ( H. pylori ) in a United States, multicenter trial. Methods Patients referred for EGD at three medical centers were recruited. During EGD, biopsies were taken for histology and rapid urease testing (RUT). Immediately after endoscopy, patients underwent the antibody tests (FlexPack HP, Abbott Diagnostics; QuikVue, Quidel Corporation; AccuMeter, ChemTrak) using whole blood obtained by two to three fingersticks. Performance characteristics were calculated for each antibody test using the biopsy-based methods as a gold standard. Results A total of 131 patients participated; 50 (38%) patients had histological evidence of H. pylori infection. Using histology as a gold standard, the sensitivities of FlexPack HP, QuikVue, and Accumeter were 76%, 78%, and 84%, respectively. Specificity was 79% with FlexPack HP and 90% with QuikVue and Accumeter. There were no significant differences in the performance of the three antibody tests though there was a trend toward superior performance for AccuMeter compared to FlexPack HP ( p = 0.019 ). However, RUT proved superior to FlexPack HP using histology as a gold standard ( p = 0.008 ). Using either concordant histology and RUT results or a positive histology or RUT to define active H. pylori infection, there was no statistically significant difference between the antibody tests. Conclusions There were no statistically significant differences in the performance of the three antibody tests. These tests proved only marginally sensitive in detecting patients infected with H. pylori . Clinicians should be aware of the limitations of these tests, particularly when using them as a sole means of testing for H. pylori .Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72148/1/j.1572-0241.1999.1135_x.x.pd
The Chemtrak Hp Chek Fingerstick Whole Blood Serology Test for the Detection of Helicobacter pylori Infection
To evaluate a new whole blood serology test (Hp Chek; ChemTrak) that detects IgG antibodies to Helicobacter pylori . Methods : The study was conducted at 10 sites within the United States. Patients undergoing upper endoscopy for dyspepsia were recruited for enrollment. Those treated for H. pylori infection within a year of endoscopy and those who had regularly used proton pump inhibitors, bismuth compounds, or antibiotics within a month of endoscopy were not eligible. During endoscopy, specimens were obtained from the corpus and antrum for histological examination, which was performed by a single experienced pathologist. The Hp Chek was tested using whole blood and serum. Serum was also tested with a reference enzyme-linked immunosorbent assay (ELISA) at a centralized location. Test characteristics for the Hp Chek and ELISA were calculated using histology as the “gold standard.”. Results : Two hundred eighty-seven patients (140 women and 147 men; mean age 53 ± 6 yr ) were enrolled. The Hp Chek was easy to perform and yielded results 9 min after inoculation of the test cassette with whole blood or serum. When the Hp Chek used with whole blood was compared with histology as the gold standard, the sensitivity was 88%, specificity 85%, positive predictive value 83%, negative predictive value 90%, and percent agreement 86%. There were no statistically significant differences among the results obtained with the Hp Chek using whole blood, the Hp Chek using serum, or reference ELISA. Conclusions : The Hp Chek whole blood serology test was easy to perform and rapid and yielded performance characteristics comparable to those of a reference ELISA or the Hp Chek used with serum.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75251/1/j.1572-0241.1998.016_c.x.pd
STM conductance of Kondo impurities on open and structured surfaces
We study the scanning tunneling microscopy response for magnetic atoms on
open and structured surfaces using Wilson's renormalization group. We observe
Fano resonances associated with Kondo resonances and interference effects. For
a magnetic atom in a quantum corral coupled to the confined surface states, and
experimentally relevant parameters, we observe a large confinement induced
effect not present in the experiments. These results suggest that the Kondo
screening is dominated by the bulk electrons rather than the surface ones.Comment: 6 pages, 6 figure
Edge reconstructions in fractional quantum Hall systems
Two dimensional electron systems exhibiting the fractional quantum Hall
effects are characterized by a quantized Hall conductance and a dissipationless
bulk. The transport in these systems occurs only at the edges where gapless
excitations are present. We present a {\it microscopic} calculation of the edge
states in the fractional quantum Hall systems at various filling factors using
the extended Hamiltonian theory of the fractional quantum Hall effect. We find
that at the quantum Hall edge undergoes a reconstruction as the
background potential softens, whereas quantum Hall edges at higher filling
factors, such as , are robust against reconstruction. We present
the results for the dependence of the edge states on various system parameters
such as temperature, functional form and range of electron-electron
interactions, and the confining potential. Our results have implications for
the tunneling experiments into the edge of a fractional quantum Hall system.Comment: 11 pages, 9 figures; minor typos corrected; added 2 reference
In-orbit Performance of UVIT on ASTROSAT
We present the in-orbit performance and the first results from the
ultra-violet Imaging telescope (UVIT) on ASTROSAT. UVIT consists of two
identical 38cm coaligned telescopes, one for the FUV channel (130-180nm) and
the other for the NUV (200-300nm) and VIS (320-550nm) channels, with a field of
view of 28 . The FUV and the NUV detectors are operated in the high
gain photon counting mode whereas the VIS detector is operated in the low gain
integration mode. The FUV and NUV channels have filters and gratings, whereas
the VIS channel has filters. The ASTROSAT was launched on 28th September 2015.
The performance verification of UVIT was carried out after the opening of the
UVIT doors on 30th November 2015, till the end of March 2016 within the
allotted time of 50 days for calibration. All the on-board systems were found
to be working satisfactorily. During the PV phase, the UVIT observed several
calibration sources to characterise the instrument and a few objects to
demonstrate the capability of the UVIT. The resolution of the UVIT was found to
be about 1.4 - 1.7 in the FUV and NUV. The sensitivity in various
filters were calibrated using standard stars (white dwarfs), to estimate the
zero-point magnitudes as well as the flux conversion factor. The gratings were
also calibrated to estimate their resolution as well as effective area. The
sensitivity of the filters were found to be reduced up to 15\% with respect to
the ground calibrations. The sensitivity variation is monitored on a monthly
basis. UVIT is all set to roll out science results with its imaging capability
with good resolution and large field of view, capability to sample the UV
spectral region using different filters and capability to perform variability
studies in the UV.Comment: 10 pages, To appear in SPIE conference proceedings, SPIE conference
paper, 201
Real-space renormalization group approach for the corner Hamiltonian
We present a real-space renormalization group approach for the corner
Hamiltonian, which is relevant to the reduced density matrix in the density
matrix renormalization group. A set of self-consistent equations that the
renormalized Hamiltonian should satisfy in the thermodynamic limit is also
derived from the fixed point of the recursion relation for the corner
Hamiltonian. We demonstrate the renormalization group algorithm for the
XXZ spin chain and show that the results are consistent with the exact
solution. We further examine the renormalization group for the S=1 Heisenberg
spin chain and then discuss the nature of the eigenvalue spectrum of the corner
Hamiltonian for the non-integrable model.Comment: 7 page
- …