Quantitative modeling of reliability and survivability for cyber-physical power systems

Critical infrastructure systems are increasingly reliant on cyber infrastructure that enables intelligent real-time control of physical components. This cyber infrastructure utilizes environmental and operational data to provide decision support intended to increase the efficacy and reliability of the system and facilitate mitigation of failure. Realistic imperfections, such as corrupt sensor data, software errors, or failed communication links can cause failure in a functional physical infrastructure, defying the purpose of intelligent control. As such, justifiable reliance on cyber-physical critical infrastructure is contingent on rigorous investigation of the effect of intelligent control, including modeling and simulation of failure propagation within the cyber-physical infrastructure. To this end, this thesis investigates the reliability and survivability of a cyber-physical power grid based on the IEEE 9-bus test system. The research contributions include quantitative modeling of both non-functional attributes, based on data from N-1 contingency analysis that considers failures in physical and cyber components of the system. The resulting survivability model is utilized in determining the importance of each transmission line. The final research contribution is identification of optimal recovery strategies for the system, where the objective is to maintain the highest possible survivability in the course of recovery. --Abstract, page iii

Analysis of Reliability and Resilience for Smart Grids

Smart grids, where cyber infrastructure is used to make power distribution more dependable and efficient, are prime examples of modern infrastructure systems. The cyber infrastructure provides monitoring and decision support intended to increase the dependability and efficiency of the system. This comes at the cost of vulnerability to accidental failures and malicious attacks, due to the greater extent of virtual and physical interconnection. Any failure can propagate more quickly and extensively, and as such, the net result could be lowered reliability. In this paper, we describe metrics for assessment of two phases of smart grid operation: the duration before a failure occurs, and the recovery phase after an inevitable failure. The former is characterized by reliability, which we determine based on information about cascading failures. The latter is quantified using resilience, which can in turn facilitate comparison of recovery strategies. We illustrate the application of these metrics to a smart grid based on the IEEE 9-bus test system

Solid Organ Rejection following SARS-CoV-2 Vaccination or COVID-19 Infection: A Systematic Review and Meta-Analysis

Background: Solid organ rejection post-SARS-CoV-2 vaccination or COVID-19 infection is extremely rare but can occur. T-cell recognition of antigen is the primary and central event that leads to the cascade of events that result in rejection of a transplanted organ. Objectives: To describe the results of a systematic review for solid organ rejections following SARS-CoV-2 vaccination or COVID-19 infection. Methods: For this systematic review and meta-analysis, we searched Proquest, Medline, Embase, Pubmed, CINAHL, Wiley online library, Scopus and Nature through the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines for studies on the incidence of solid organ rejection post-SARS-CoV-2 vaccination or COVID-19 infection, published from 1 December 2019 to 31 May 2022, with English language restriction. Results: One hundred thirty-six cases from fifty-two articles were included in the qualitative synthesis of this systematic review (56 solid organs rejected post-SARS-CoV-2 vaccination and 40 solid organs rejected following COVID-19 infection). Cornea rejection (44 cases) was the most frequent organ observed post-SARS-CoV-2 vaccination and following COVID-19 infection, followed by kidney rejection (36 cases), liver rejection (12 cases), lung rejection (2 cases), heart rejection (1 case) and pancreas rejection (1 case). The median or mean patient age ranged from 23 to 94 years across the studies. The majority of the patients were male (n = 51, 53.1%) and were of White (Caucasian) (n = 51, 53.7%) and Hispanic (n = 15, 15.8%) ethnicity. A total of fifty-six solid organ rejections were reported post-SARS-CoV-2 vaccination [Pfizer-BioNTech (n = 31), Moderna (n = 14), Oxford Uni-AstraZeneca (n = 10) and Sinovac-CoronaVac (n = 1)]. The median time from SARS-CoV-2 vaccination to organ rejection was 13.5 h (IQR, 3.2–17.2), while the median time from COVID-19 infection to organ rejection was 14 h (IQR, 5–21). Most patients were easily treated without any serious complications, recovered and did not require long-term allograft rejection therapy [graft success (n = 70, 85.4%), graft failure (n = 12, 14.6%), survived (n = 90, 95.7%) and died (n = 4, 4.3%)]. Conclusion: The reported evidence of solid organ rejections post-SARS-CoV-2 vaccination or COIVD-19 infection should not discourage vaccination against this worldwide pandemic. The number of reported cases is relatively small in relation to the hundreds of millions of vaccinations that have occurred, and the protective benefits offered by SARS-CoV-2 vaccination far outweigh the risks