621 research outputs found

    (WP 2013-03) War and the Fiscal Capacity of the State

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    We examine the role of war in retarding state fiscal capacity in developing countries, measured by tax revenue ratios to GDP. This in contrast to the European experience from the Renaissance to the 20th century, where it is believed that war and state-building were inseparable, enhancing the fiscal capacity of the state; in turn enlarging the scope and magnitude of government expenditure. We build a simple theoretical model of a factionalized state, where patronage substitutes for common interest public goods, along with the possibility of violent contestation over a rent or prize, typically in the form of natural resource revenues. Our dynamic panel empirical analysis on the determinants of fiscal capacity is applied to 79 developing countries, during 1980-2010. Results indicate that war, especially in its current dominant form of civil war, retards fiscal capacity, along with imperfect democracy, political repression, the quality of governance, dependence on oil and macroeconomic mismanagement. High intensity conflict is particularly destructive of state capacity. Countries experiencing low intensity wars, other institutional factors may matter more for fiscal capacity formation compared to war. The diminution of state capacity due to war appears less pronounced after the end of the cold war

    Immune checkpoints in circulating and tumor-Infiltrating CD4 + T Cell Subsets in Colorectal cancer patients

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    Blockade of inhibitory immune checkpoints (ICs) is a promising therapeutic approach; however, it has shown limited success in some cancers including colorectal cancer (CRC). The tumor microenvironment (TME) is largely responsible for response to therapy, and its constituents may provide robust biomarkers for successful immunotherapeutic approaches. In this study, we performed phenotypical characterization and critical analyses of key inhibitory ICs and T regulatory cell (Treg)-related markers on CD4+ T cell subsets in CRC patients, and compared with normal colon tissues and peripheral blood from the same patients. We also investigated correlations between the levels of different CD4+ T cell subsets and the clinicopathologic features including disease stage and tumor budding. We found a significant increase in the levels of CD4+FoxP3+Helios+ T cells, which represent potentially highly immunosuppressive Tregs, in the CRC TME. Additionally, tumor-infiltrating CD4+ T cells upregulated programmed cell death protein-1 (PD-1), cytotoxic T-lymphocyte-associated protein-4 (CTLA-4), T cell immunoglobulin and mucin domain-3 (TIM-3) and lymphocyte-activation gene 3 (LAG-3). We also characterized the expression of PD-1, CTLA-4, TIM-3, and LAG-3 on different CD4+FoxP3−/+Helios−/+ T cell subsets. Interestingly, we found that CTLA-4, TIM-3, and LAG-3 were mainly co-expressed on FoxP3+Helios+ Tregs in the TME. Additionally, FoxP3high Tregs expressed higher levels of Helios, CTLA-4 and TIM-3 than FoxP3low T cells. These results highlight the significance of Tregs in the CRC TME and suggest that Tregs may hamper response to IC blockade in CRC patients, but effects of different IC inhibition regimes on Treg levels or activity warrants further investigations. We also found that CD4+CTLA-4+ T cells in circulation are increased in patients with advanced disease stage. This study simultaneously provides important insights into the differential levels of CD4+ T cell subpopulations and IC expression in CRC TME, compared to periphery and associations with clinicopathologic features, which could be used as potential biomarkers for CRC progression and response to therapy

    Introductory Chapter: Electronics Cooling — An Overview

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    Pattern of skeletal metastasis in breast cancer patients of northern part of Bangladesh

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    Background: Breast cancer is the most frequent female cancer, especially in 'developed' countries. 30-85% of metastatic breast cancer patients will develop bone metastases during the course of the disease. The study was aimed to evaluate the pattern of skeletal metastasis in breast cancer patients with whole body bone scan using 99mTechnetium methyl diphosphonate (99m'Tc-MDP). Methods: This single center based retrospective observational study was conducted among the histopathologically proven breast cancer patients referred to INMAS, Rangpur for 99m'Tc-MDP bone scintigraphy between March 2015 and March 2019. Bone scan was done with SPECT digital dual head gamma camera (Siemens S series) 3 hours after intravenous bolus injection of 20 mci99mI'c-MDP. Results: Out of total 300 patients, 120 (40%) patients were found secondaries in bones. Among them 80(66.7%) had only axial skeletal metastases and 15 (12.5%) had appendicular skeletal metastases. Both axial and appendicle skeletal metastases were found in 25 (20.8%) patients.  Conclusion: Thoraco-lumbar spine was the most common site of involvement in our study.

    Enhanced cell visiting probability for QoS provisioning in mobile multimedia communications

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    This paper presents an enhanced cell visiting probability (CVP) estimation technique by integrating both mobility parameters such as position, direction, and speed together with exponential call duration probability of mobile units. These improved CVP estimates can be used in both adaptive and nonadaptive mobile networks to enhance QoS parameters. This paper also presents a new shadow-clustering scheme based on these enhanced CVPs, which is then applied to the call admission control scheme similar to the one, called predictive mobility support QoS provisioning scheme, proposed by Aljadhai and Znati (2001). Simulation results confirm that this new shadow-clustering scheme outperforms predictive mobility support QoS provisioning scheme in terms of different QoS parameters under various different traffic conditions

    Review of aquaculture and fish consumption in Bangladesh

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    Fish play a crucial role in the Bangladeshi diet, providing more than 60% of animal source food, representing a crucial source of micro-nutrients, and possessing an extremely strong cultural attachment. Fish (including shrimp and prawn) is the second most valuable agricultural crop, and its production contributes to the livelihoods and employment of millions. The culture and consumption of fish therefore has important implications for national food and nutrition security, poverty and growth. This review examines the current state of knowledge on the aquaculture sector and fish consumption in Bangladesh, based on extensive analysis of secondary sources (including unpublished data unavailable elsewhere), consultation with various experts and specially conducted surveys. The review is comprised of three sections. Section 1 describes the main systems of aquaculture production in terms of their technical and social characteristics and outputs. Section 2 addresses issues relating to seed and feed. The final section analyses fish consumption patterns and demand, and attempts to estimate the volumes of fish produced from a range of sources.Food fish, Aquaculture, Food consumption, Fish consumption, Pond culture, Rice field aquaculture, Bangladesh,
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