Process mapping of laser surface modification of AISI 316L stainless steel for biomedical applications

A 1.5-kW CO2 laser in pulsed mode at 3 kHz was used to investigate the effects of varied laser process parameters and resulting morphology of AISI 316L stainless steel. Irradiance and residence time were varied between 7.9 to 23.6 MW/cm2 and 50 to 167 µs respectively. A strong correlation between irradiance, residence time, depth of processing and roughness of processed steel was established. The high depth of altered microstructure and increased roughness were linked to higher levels of both irradiance and residence times. Energy fluence and surface temperature models were used to predict levels of melting occurring on the surface through the analysis of roughness and depth of the region processed. Microstructural images captured by the SEM revealed significant grain structure changes at higher irradiances, but due to increased residence times, limited to the laser in use, the hardness values were not improved

Phenomenological constraints on Lemaitre-Tolman-Bondi cosmological inhomogeneities from solar system dynamics

We, first, analytically work out the long-term, i.e. averaged over one orbital revolution, perturbations on the orbit of a test particle moving in a local Fermi frame induced therein by the cosmological tidal effects of the inhomogeneous Lemaitre-Tolman-Bondi (LTB) model. The LTB solution has recently attracted attention, among other things, as a possible explanation of the observed cosmic acceleration without resorting to dark energy. Then, we phenomenologically constrain both the parameters K_1 = -\ddot R/R and K_2 = -\ddot R^'/R^' of the LTB metric in the Fermi frame by using different kinds of solar system data. The corrections $\Delta\dot\varpi$ to the standard Newtonian/Einsteinian precessions of the perihelia of the inner planets recently estimated with the EPM ephemerides, compared to our predictions for them, yield K_1 = (4+8) 10^-26 s^-2, K_2 = (3+7) 10^-23 s^-2. The residuals of the Cassini-based Earth-Saturn range, compared with the numerically integrated LTB range signature, allow to obtain K_1/2 = 10^-27 s^-2. The LTB-induced distortions of the orbit of a typical object of the Oort cloud with respect to the commonly accepted Newtonian picture, based on the observations of the comet showers from that remote region of the solar system, point towards K_1/2 <= 10^-30-10^-32 s^-2. Such figures have to be compared with those inferred from cosmological data which are of the order of K1 \approx K2 = -4 10^-36 s^-2.Comment: LaTex2e, 18 pages, 3 tables, 3 figures. Minor changes. Reference added. Accepted by Journal of Cosmology and Astroparticle Physics (JCAP

Steps to Develop Early Warning Systems and Future Scenarios of Storm Wave-Driven Flooding Along Coral Reef-Lined Coasts

ABSTRACT: Tropical coral reef-lined coasts are exposed to storm wave-driven flooding. In the future, flood events during storms are expected to occur more frequently and to be more severe due to sea-level rise, changes in wind and weather patterns, and the deterioration of coral reefs. Hence, disaster managers and coastal planners are in urgent need of decision-support tools. In the short-term, these tools can be applied in Early Warning Systems (EWS) that can help to prepare for and respond to impending storm-driven flood events. In the long-term, future scenarios of flooding events enable coastal communities and managers to plan and implement adequate risk-reduction strategies. Modeling tools that are used in currently available coastal flood EWS and future scenarios have been developed for open-coast sandy shorelines, which have only limited applicability for coral reef-lined shorelines. The tools need to be able to predict local sea levels, offshore waves, as well as their nearshore transformation over the reefs, and translate this information to onshore flood levels. In addition, future scenarios require long-term projections of coral reef growth, reef composition, and shoreline change. To address these challenges, we have formed the UFORiC (Understanding Flooding of Reef-lined Coasts) working group that outlines its perspectives on data and model requirements to develop EWS for storms and scenarios specific to coral reef-lined coastlines. It reviews the state-of-the-art methods that can currently be incorporated in such systems and provides an outlook on future improvements as new data sources and enhanced methods become available

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Tidal Evolution of Close Binary Asteroid Systems

We provide a generalized discussion of tidal evolution to arbitrary order in the expansion of the gravitational potential between two spherical bodies of any mass ratio. To accurately reproduce the tidal evolution of a system at separations less than five times the radius of the larger primary component, the tidal potential due to the presence of a smaller secondary component is expanded in terms of Legendre polynomials to arbitrary order rather than truncated at leading order as is typically done in studies of well-separated system like the Earth and Moon. The equations of tidal evolution including tidal torques, the changes in spin rates of the components, and the change in semimajor axis (orbital separation) are then derived for binary asteroid systems with circular and equatorial mutual orbits. Accounting for higher-order terms in the tidal potential serves to speed up the tidal evolution of the system leading to underestimates in the time rates of change of the spin rates, semimajor axis, and mean motion in the mutual orbit if such corrections are ignored. Special attention is given to the effect of close orbits on the calculation of material properties of the components, in terms of the rigidity and tidal dissipation function, based on the tidal evolution of the system. It is found that accurate determinations of the physical parameters of the system, e.g., densities, sizes, and current separation, are typically more important than accounting for higher-order terms in the potential when calculating material properties. In the scope of the long-term tidal evolution of the semimajor axis and the component spin rates, correcting for close orbits is a small effect, but for an instantaneous rate of change in spin rate, semimajor axis, or mean motion, the close-orbit correction can be on the order of tens of percent.Comment: 40 pages, 2 tables, 8 figure

A resonant-term-based model including a nascent disk, precession, and oblateness: application to GJ 876

Investigations of two resonant planets orbiting a star or two resonant satellites orbiting a planet often rely on a few resonant and secular terms in order to obtain a representative quantitative description of the system's dynamical evolution. We present a semianalytic model which traces the orbital evolution of any two resonant bodies in a first- through fourth-order eccentricity or inclination-based resonance dominated by the resonant and secular arguments of the user's choosing. By considering the variation of libration width with different orbital parameters, we identify regions of phase space which give rise to different resonant ''depths,'' and propose methods to model libration profiles. We apply the model to the GJ 876 extrasolar planetary system, quantify the relative importance of the relevant resonant and secular contributions, and thereby assess the goodness of the common approximation of representing the system by just the presumably dominant terms. We highlight the danger in using ''order'' as the metric for accuracy in the orbital solution by revealing the unnatural libration centers produced by the second-order, but not first-order, solution, and by demonstrating that the true orbital solution lies somewhere ''in-between'' the third- and fourth-order solutions. We also present formulas used to incorporate perturbations from central-body oblateness and precession, and a protoplanetary or protosatellite thin disk with gaps, into a resonant system. We quantify these contributions to the GJ 876 system, and thereby highlight the conditions which must exist for multi-planet exosystems to be significantly influenced by such factors. We find that massive enough disks may convert resonant libration into circulation; such disk-induced signatures may provide constraints for future studies of exoplanet systems.Comment: 39 pages of body text, 21 figures, 5 tables, 1 appendix, accepted for publication in Celestial Mechanics and Dynamical Astronom

Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation

Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in asthmatic patients is unclear. Objective: We sought to explore the association between epithelial IL-6TS pathway activation and molecular and clinical phenotypes in asthmatic patients. Methods: An IL-6TS gene signature obtained from air-liquid interface cultures of human bronchial epithelial cells stimulated with IL-6 and sIL-6R was used to stratify lung epithelial transcriptomic data (Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes [U-BIOPRED] cohorts) by means of hierarchical clustering. IL-6TS-specific protein markers were used to stratify sputum biomarker data (Wessex cohort). Molecular phenotyping was based on transcriptional profiling of epithelial brushings, pathway analysis, and immunohistochemical analysis of bronchial biopsy specimens. Results: Activation of IL-6TS in air-liquid interface cultures reduced epithelial integrity and induced a specific gene signature enriched in genes associated with airway remodeling. The IL-6TS signature identified a subset of patients with IL-6TS-high asthma with increased epithelial expression of IL-6TS-inducible genes in the absence of systemic inflammation. The IL-6TS-high subset had an overrepresentation of frequent exacerbators, blood eosinophilia, and submucosal infiltration of T cells and macrophages. In bronchial brushings Toll-like receptor pathway genes were upregulated, whereas expression of cell junction genes was reduced. Sputum sIL-6R and IL-6 levels correlated with sputum markers of remodeling and innate immune activation, in particular YKL-40, matrix metalloproteinase 3, macrophage inflammatory protein 1 beta, IL-8, and IL-1 beta. Conclusions: Local lung epithelial IL-6TS activation in the absence of type 2 airway inflammation defines a novel subset of asthmatic patients and might drive airway inflammation and epithelial dysfunction in these patients.Peer reviewe

Report on the sixth blind test of organic crystal-structure prediction methods

The sixth blind test of organic crystal-structure prediction (CSP) methods has been held, with five target systems: a small nearly rigid molecule, a polymorphic former drug candidate, a chloride salt hydrate, a co-crystal, and a bulky flexible molecule. This blind test has seen substantial growth in the number of submissions, with the broad range of prediction methods giving a unique insight into the state of the art in the field. Significant progress has been seen in treating flexible molecules, usage of hierarchical approaches to ranking structures, the application of density-functional approximations, and the establishment of new workflows and "best practices" for performing CSP calculations. All of the targets, apart from a single potentially disordered Z` = 2 polymorph of the drug candidate, were predicted by at least one submission. Despite many remaining challenges, it is clear that CSP methods are becoming more applicable to a wider range of real systems, including salts, hydrates and larger flexible molecules. The results also highlight the potential for CSP calculations to complement and augment experimental studies of organic solid forms