Existence and Stability of Standing Pulses in Neural Networks : I Existence

We consider the existence of standing pulse solutions of a neural network integro-differential equation. These pulses are bistable with the zero state and may be an analogue for short term memory in the brain. The network consists of a single-layer of neurons synaptically connected by lateral inhibition. Our work extends the classic Amari result by considering a non-saturating gain function. We consider a specific connectivity function where the existence conditions for single-pulses can be reduced to the solution of an algebraic system. In addition to the two localized pulse solutions found by Amari, we find that three or more pulses can coexist. We also show the existence of nonconvex ``dimpled'' pulses and double pulses. We map out the pulse shapes and maximum firing rates for different connection weights and gain functions.Comment: 31 pages, 29 figures, submitted to SIAM Journal on Applied Dynamical System

The Ursinus Weekly, January 8, 1962

Former Ursinusite, now Africa expert, to address Forum Wednesday night • Soc. classes hear prejudice speaker • Volunteer U.C. students pitch in at local Catholic boys\u27 protectory • Dr. Pancoast takes oath as mayor of Collegeville • President\u27s report reveals 1961 data, interesting facts • Fifty students attend open meeting; MSGA\u27s Moll airs campus problems • U.C. receives $2000 from Standard Oil • Delaware museum offers five grants • Day students tell Y of difficulties • Bill Scholl named to MAC first team • Eye surgery to be topic of next pre-med meeting • Singers choose Kershner 1962 business manager • Editorial: The right not to participate • Ursinus in the past • The New Lost City Ramblers at Haverford College • All Italian highways lead to Rome, the city of colorful contrasts • Twenty freshmen answer Weekly competition call • Cagers still seek win key; Losing streak at five games • Grapplers crunch Haverford, 31 to 3, in season\u27s opener • Freshman wrestler Fred Powers adds strength in the 157 lb. weight class • Ursinus again to host county science fairhttps://digitalcommons.ursinus.edu/weekly/1308/thumbnail.jp

A Subset of Liver NK T Cells is Activated During \u3cem\u3eLeishmania donovani\u3c/em\u3e Infection by CD1d-Bound Lipophosphoglycan

Natural killer (NK) T cells are activated by synthetic or self-glycolipids and implicated in innate host resistance to a range of viral, bacterial, and protozoan pathogens. Despite the immunogenicity of microbial lipoglycans and their promiscuous binding to CD1d, no pathogen-derived glycolipid antigen presented by this pathway has been identified to date. In the current work, we show increased susceptibility of NK T cell–deficient CD1d−/− mice to Leishmania donovani infection and Leishmania-induced CD1d-dependent activation of NK T cells in wild-type animals. The elicited response was Th1 polarized, occurred as early as 2 h after infection, and was independent from IL-12. The Leishmania surface glycoconjugate lipophosphoglycan, as well as related glycoinositol phospholipids, bound with high affinity to CD1d and induced a CD1d-dependent IFNγ response in naive intrahepatic lymphocytes. Together, these data identify Leishmania surface glycoconjugates as potential glycolipid antigens and suggest an important role for the CD1d–NK T cell immune axis in the early response to visceral Leishmania infection

A Subset of Liver NK T Cells Is Activated during Leishmania donovani Infection by CD1d-bound Lipophosphoglycan

Natural killer (NK) T cells are activated by synthetic or self-glycolipids and implicated in innate host resistance to a range of viral, bacterial, and protozoan pathogens. Despite the immunogenicity of microbial lipoglycans and their promiscuous binding to CD1d, no pathogen-derived glycolipid antigen presented by this pathway has been identified to date. In the current work, we show increased susceptibility of NK T cell–deficient CD1d−/− mice to Leishmania donovani infection and Leishmania-induced CD1d-dependent activation of NK T cells in wild-type animals. The elicited response was Th1 polarized, occurred as early as 2 h after infection, and was independent from IL-12. The Leishmania surface glycoconjugate lipophosphoglycan, as well as related glycoinositol phospholipids, bound with high affinity to CD1d and induced a CD1d-dependent IFNγ response in naive intrahepatic lymphocytes. Together, these data identify Leishmania surface glycoconjugates as potential glycolipid antigens and suggest an important role for the CD1d–NK T cell immune axis in the early response to visceral Leishmania infection

Estimating the horizontal and vertical direction-of-arrival of water-borne seismic signals in the northern Philippine Sea

Author Posting. © Acoustical Society of America, 2013. This article is posted here by permission of Acoustical Society of America for personal use, not for redistribution. The definitive version was published in Journal of the Acoustical Society of America 134 (2013): 3282, doi:10.1121/1.4818843.Conventional and adaptive plane-wave beamforming with simultaneous recordings by large-aperture horizontal and vertical line arrays during the 2009 Philippine Sea Engineering Test (PhilSea09) reveal the rate of occurrence and the two-dimensional arrival structure of seismic phases that couple into the deep ocean. A ship-deployed, controlled acoustic source was used to evaluate performance of the horizontal array for a range of beamformer adaptiveness levels. Ninety T-phases from unique azimuths were recorded between Yeardays 107 to 119. T-phase azimuth and S-minus-P-phase time-of-arrival range estimates were validated using United States Geological Survey seismic monitoring network data. Analysis of phases from a seismic event that occurred on Yearday 112 near the east coast of Taiwan approximately 450 km from the arrays revealed a 22° clockwise evolution of T-phase azimuth over 90 s. Two hypotheses to explain such evolution—body wave excitation of multiple sources or in-water scattering—are presented based on T-phase origin sites at the intersection of azimuthal great circle paths and ridge/coastal bathymetry. Propagation timing between the source, scattering region, and array position suggests the mechanism behind the evolution involved scattering of the T-phase from the Ryukyu Ridge and a T-phase formation/scattering location estimation error of approximately 3.2 km.This research is supported by the Office of Naval Research, both the Applied Research Laboratory program and Code 322(OA)

Deep water towed array measurements at close range

Author Posting. © Acoustical Society of America, 2013. This article is posted here by permission of Acoustical Society of America for personal use, not for redistribution. The definitive version was published in Journal of the Acoustical Society of America 134 (2013): 3230, doi:10.1121/1.4818869.During the North Pacific Acoustic Laboratory Philippine Sea 2009 experiment, towed array receptions were made from a towed source as the two ships transited from a separation of several Convergence Zones through a Closest Point of Approach at 3 km. A combination of narrowband tones and broadband pulses were transmitted covering the frequency band 79–535 Hz. The received energy arrives from two general paths—direct path and bottom bounce. Bearing-time records of the narrowband arrivals at times show a 35° spread in the angle of arrival of the bottom bounce energy. Doppler processing of the tones shows significant frequency spread of the bottom bounce energy. Two-dimensional modeling using measured bathymetry, a geoacoustic parameterization based upon the geological record, and measured sound-speed field was performed. Inclusion of the effects of seafloor roughness and surface waves shows that in-plane scattering from rough interfaces can explain much of the observed spread in the arrivals. Evidence of out-of-plane scattering does exist, however, at short ranges. The amount of out-of-plane scattering is best observed in the broadband impulse-beam response analysis, which in-plane surface roughness modeling cannot explain.This work was supported by the Office of Naval Research, Ocean Acoustics, under contract N00014-11-M-0170

Pharmaceuticals and personal care products in the environment: What are the big questions?

Background: Over the past 10-15 years, a substantial amount of work has been done by the scientific, regulatory, and business communities to elucidate the effects and risks of pharmaceuticals and personal care products (PPCPs) in the environment. Objective: This review was undertaken to identify key outstanding issues regarding the effects of PPCPs on human and ecological health in order to ensure that future resources will be focused on the most important areas. Data sources: To better understand and manage the risks of PPCPs in the environment, we used the "key question" approach to identify the principle issues that need to be addressed. Initially, questions were solicited from academic, government, and business communities around the world. A list of 101 questions was then discussed at an international expert workshop, and a top-20 list was developed. Following the workshop, workshop attendees ranked the 20 questions by importance. Data synthesis: The top 20 priority questions fell into seven categories: a) prioritization of substances for assessment, b) pathways of exposure, c) bioavailability and uptake, d) effects characterization, e) risk and relative risk, f) antibiotic resistance, and g) risk management. Conclusions: A large body of information is now available on PPCPs in the environment. This exercise prioritized the most critical questions to aid in development of future research programs on the topic.Centro de Investigaciones del Medioambient

Synthesis and Assessment Product

This document is part of the Synthesis and Assessment Products described in the U.S. Climate Change Science Program (CCSP) Strategic Plan. Changes in extreme weather and climate events have significant impacts and are among the most serious challenges to society in coping with a changing climate. This Synthesis and Assessment Product (SAP 3.3) focuses on weather and climate extremes in a changing climate. Many extremes and their associated impacts are now changing. For example, in recent decades most of North America has been experiencing more unusually hot days and nights, fewer unusually cold days and nights, and fewer frost days. Heavy downpours have become more frequent and intense. Droughts are becoming more severe in some regions, though there are no clear trends for North America as a whole. The power and frequency of Atlantic hurricanes have increased substantially in recent decades, though North American mainland land-falling hurricanes do not appear to have increased over the past century. Outside the tropics, storm tracks are shifting northward and the strongest storms are becoming even stronger. It is well established through formal attribution studies that the global warming of the past 50 years is due primarily to human-induced increases in heat-trapping gases. Such studies have only recently been used to determine the causes of some changes in extremes at the scale of a continent. Certain aspects of observed increases in temperature extremes have been linked to human influences. The increase in heavy precipitation events is associated with an increase in water vapor, and the latter has been attributed to human-induced warming. No formal attribution studies for changes in drought severity in North America have been attempted. There is evidence suggesting a human contribution to recent changes in hurricane activity as well as in storms outside the tropics, though a confident assessment will require further study