Patterns of symptoms possibly indicative of cancer and associated help-seeking behaviour in a large sample of United Kingdom residents - the USEFUL study

Background.Cancer awareness campaigns aim to increase awareness of the potential seriousness of signs and symptoms of cancer, and encourage their timely presentation to healthcare services. Enhanced understanding of the prevalence of symptoms possibly indicative of cancer in different population subgroups, and associated general practitioner (GP) help-seeking behaviour, will help to target cancer awareness campaigns more effectively.Aim.To determine: i) the prevalence of 21 symptoms possibly indicative of breast, colorectal, lung or upper gastrointestinal cancer in the United Kingdom (UK), including six ‘red flag’ symptoms; ii) whether the prevalence varies among population subgroups; iii) the proportion of symptoms self-reported as presented to GPs; iv) whether GP help-seeking behaviour varies within population subgroups.Methods.Self-completed questionnaire about experience of, and response to, 25 symptoms (including 21 possibly indicative of the four cancers of interest) in the previous month and year; sent to 50,000 adults aged 50 years or more and registered with 21 general practices in Staffordshire, England or across Scotland. Results.Completed questionnaires were received from 16,778 respondents (corrected response rate 34.2%). Almost half (45.8%) of respondents had experienced at least one symptom possibly indicative of cancer in the last month, and 58.5% in the last year. The prevalence of individual symptoms varied widely (e.g. in the last year between near zero% (vomiting up blood) and 15.0% (tired all the time). Red flag symptoms were uncommon. Female gender, inability to work because of illness, smoking, a history of a specified medical diagnosis, low social support and lower household income were consistently associated with experiencing at least one symptom possibly indicative of cancer in both the last month and year. The proportion of people who had contacted their GP about a symptom experienced in the last month varied between 8.1% (persistent cough) and 39.9% (unexplained weight loss); in the last year between 32.8% (hoarseness) and 85.4% (lump in breast). Nearly half of respondents experiencing at least one red flag symptom in the last year did not contact their GP about it. Females, those aged 80+ years, those unable to work because of illness, ex-smokers and those previously diagnosed with a specified condition were more likely to report a symptom possibly indicative of cancer to their GP; and those on high household income less likely.Conclusion.Symptoms possibly indicative of cancer are common among adults aged 50+ years in the UK, although they are not evenly distributed. Help-seeking responses to different symptoms also vary. Our results suggest important opportunities to provide more nuanced messaging and targeting of symptom-based cancer awareness campaigns

Total skin self-examination at home for people treated for cutaneous melanoma : development and pilot of a digital intervention

This work was funded by the RCUK Digital Economy award to the dot.rural Digital Economy Hub, University of Aberdeen; award reference: EP/G066051/1. The Experience Laboratory event was supported in part by a separate award from the University of Aberdeen Knowledge Exchange and Transfer Fund; award reference: GP057 UZZ0101.Peer reviewedPublisher PD

Orientale and South Pole-Aitken basins on the Moon: Preliminary Galileo imaging results

During the Earth-Moon flyby the Galileo Solid State Imaging System obtained new information on the landscape and physical geology of the Moon. Multicolor Galileo images of the Moon reveal variations in color properties of the lunar surface. Using returned lunar samples as a key, the color differences can be interpreted in terms of variations in the mineral makeup of the lunar rocks and soil. The combined results of Apollo landings and multicolor images from Galileo allow extrapolation of surface composition to areas distant from the landing sites, including the far side invisible from Earth

Do pharmacists contribute to patients’ management of symptoms suggestive of cancer : a qualitative study

Funding This work was supported by the Sir Hugh Linstead Fellowship Award from Pharmacy Research UK. Acknowledgements The authors would like to acknowledge the support of the consultant physicians Marianne Nicolson, Russell Petty and Les Samuel Aberdeen Royal Infirmary with patient recruitment.Peer reviewedPostprin

Mechanical and Topographical Changes on Dentine Following Citric Acid Exposure

Objectives: 1. To determine the effects of short-term exposure of dentine to different concentrations and pH of citric acid; 2. To determine the stiffness and topographical changes associated with dentine erosion. Methods: Bovine incisors were prepared into 20 dentine discs (5mm3 ) and polished with 0.05\ub5m Al2 O 3 paste. Erosion was measured in terms of topographical and stiffness changes using atomic force microscope (AFM, Nanowizard 3, JPK Instruments). Specimens were exposed via the AFM liquid flow-cell to 1wt% or 6wt% citric acid, either unbuffered (pH 2.17 or 1.88, respectively) or buffered (pH 3.8) for repeated 20s cycles of citric acid up-to 120s. Baseline measured in PBS only. A representative sample was selected from each group for post-erosion scanning electron microscope (SEM) assessment. Results: Table 1 outlines stiffness results and AFM topography images demonstrate all groups post-erosion. The 1% buffered group had the least measurable changes across all time intervals and the 6% unbuffered citric acid had the greatest overall impact on the surface. The 6% buffered acid was more erosive compared with the 1% unbuffered acid, in terms of both stiffness and topography changes, between 20s and 80s exposures. However, the 1% unbuffered group had similar erosive surface changes, as for the 6% buffered samples, with increasing exposure times at 100s onwards. SEM and AFM topography showed a similar loss of peri-tubular dentine with enlargement of the tubules. AFM also demonstrated increased surface height variations with increasing exposure times and similar erosive trends to mechanical stiffness changes. Conclusions: The data shows that citric acid concentration is more critical to early erosive changes on dentine compared with a lower pH, demonstrated by stiffness elasticity reduction and structural changes. The 1% buffered group was the least erosive acid, compared with the 6% unbuffered solution which had the greatest surface changes. These AFM findings were supported by SEM dat

The effect of medications associated with drug-induced pancreatitis on pancreatic cancer risk : a nested case-control study of routine Scottish data

Funding: This work was supported by Cancer Research UK (reference C37316/A25535). Acknowledgements: We wish to thank PCCIUR, University of Aberdeen, especially Artur Wozniak, for extracting the data and performing case-control matching.Peer reviewedPublisher PD

What are the current challenges of managing cancer pain and could digital technologies help?

OBJECTIVES: Pain remains a problem for people with cancer despite effective treatments being available. We aimed to explore current pain management strategies used by patients, caregivers and professionals and to investigate opportunities for digital technologies to enhance cancer pain management. METHODS: A qualitative study comprising semistructured interviews and focus groups. Patients with cancer pain, their caregivers and health professionals from Northeast Scotland were recruited from a purposive sample of general practices. Professionals were recruited from regional networks. RESULTS: Fifty one participants took part in 33 interviews (eight patients alone, six patient/caregiver dyads and 19 professionals) and two focus groups (12 professionals). Living with cancer was hard work for patients and caregivers and comparable to a 'full-time job'. Patients had personal goals which involved controlling pain intensity and balancing this with analgesic use, side effects, overall symptom burden and social/physical activities.Digital technologies were embraced by most patients, and made living life with advanced cancer easier and richer (eg, video calls with family). Technology was underutilised for pain and symptom management. There were suggestions that technology could support self-monitoring and communicating problems to professionals, but patients and professionals were concerned about technological monitoring adding to the work of managing illness. CONCLUSIONS: Cancer pain management takes place in the context of multiple, sometimes competing personal goals. It is possible that technology could be used to help patients share individual symptom experiences and goals, thus enhancing tailored care. The challenge is for digital solutions to add value without adding undue burden

Disk-resolved spectral reflectance properties of Phobos from 0.3-3.2 micron: Preliminary integrated results from Phobos 2

The Phobos 2 mission provided multispectral observations of Phobos over a large wavelength range and with relatively high spectral resolution. Here, researchers integrate results from three multispectral detectors by determining the ultraviolet-visible near infrared spectral properties of color and brightness features recognized in VSK TV images. Researchers present evidence that there are two fundamental spectral units within the region of overlapping coverage by the detectors. They describe the units' spectral and reflectance properties and discuss the implications of these results for the composition of Phobos

Challenges in the Search for Perchlorate and Other Hydrated Minerals With 2.1-μm Absorptions on Mars

A previously unidentified artifact has been found in Compact Reconnaissance Imaging Spectrometer for Mars targeted I/F data. It exists in a small fraction (<0.05%) of pixels within 90% of images investigated and occurs in regions of high spectral/spatial variance. This artifact mimics real mineral absorptions in width and depth and occurs most often at 1.9 and 2.1 μm, thus interfering in the search for some mineral phases, including alunite, kieserite, serpentine, and perchlorate. A filtering step in the data processing pipeline, between radiance and I/F versions of the data, convolves narrow artifacts (“spikes”) with real atmospheric absorptions in these wavelength regions to create spurious absorption-like features. The majority of previous orbital detections of alunite, kieserite, and serpentine we investigated can be confirmed using radiance and raw data, but few to none of the perchlorate detections reported in published literature remain robust over the 1.0- to 2.65-μm wavelength range