PDW and RDW are new parameters for bipolar episodes and unipolar depression

INTRODUCTION: Bipolar disorder (BD) and unipolar depression (UD) are complex and multifactorial mental disorders characterized by mood swings, disability, and impaired quality of life. In the present study, we researched the roles of inflammatory cells and their value as inflammation markers in BD and UD. OBJECTIVE: Sixty-nine manic, 60 euthymic, and 70 UD patients and 60 sex-matched healthy volunteers (control group) were retrospectively analysed. Platelet (PLT), platelet distribution width (PDW), and red cell distribution width (RDW) levels were measured in four groups. The aim of this study was to evaluate PLT, PDW, and RDW levels patient with UD and two different phases of BD: euthymic and manic. RESULTS: In our study, 199 patients and 60 controls were included. There were no differences between the patients and the healthy control group participants in terms of age and sex. The bipolar episodes and the UD patient group were statistically significantly different from the healthy controls in terms of PLT, PDW, and RDW. CONCLUSION: Our study is the first in the literature to compare blood PLT, PDW, and RDW levels in bipolar episodes, UD patients, and healthy control groups. We believe that the levels of PLT, PDW, and RDW can be used as novel markers of bipolar episodes and UD. More detailed and larger prospective clinical studies are required to confirm these findings

Treatment of ADHD in a patient with Brugada syndrome: a case report and a brief review

The Brugada syndrome is one of the common causes of sudden cardiac arrest in healthy-appearing adults. The use of drugs in the treatment of this disease may give variable and unwanted results. Attention-deficit/hyperactivity disorder (ADHD) is a chronic neurobehavioural disorder which has begun to be noticed in adults as much as children. In our case, we present a 39-year-old male patient with an ADHD who was diagnosed with the Brugada syndrome during a routine examination and we discuss the treatment of this case. The association of ADHD and Brugada syndrome has not been previously reported in any clinical study. As far as we know, the present case is the first article in the literature to discuss the follow-up and treatment of ADHD in a patient with the Brugada syndrome. We observed all medical and non-medical treatment methods for ADHD treatment and discussed these methods such as psychostimulants, atomoxetine, bupropion, and psychotherapy