Osimertinib as treatment for EGFR exon 20 insertion-positive lung adenocarcinoma

A 20-year-old woman was diagnosed with stage 4 lung adenocarcinoma with an epidermal growth factor receptor (EGFR) exon 20 insertion gene mutation. Although the patient underwent chemotherapy, her lesions progressed. Liquid biopsy for EGFR T790M mutation showed negative results. After administering osimertinib, reduction of the lesions at the primary site was observed, and the patient’s respiratory condition improved. Previous reports showing successful treatment of EGFR exon 20 insertion-positive lung adenocarcinoma with the standard osimertinib dose of 80 mg are limited. The present case demonstrated that osimertinib could be a possible treatment option for EGFR exon 20 insertion-positive lung adenocarcinoma

Evaluation of the Environmental Burden of Cross-Laminated Timber Manufacturing in Japan Using the Input–Output Analysis

Japan is actively promoting the application of cross-laminated timber (CLT) in construction to utilize plantation forests efficiently and fulfil its climate commitments. Although CLT has unique structural properties and environmental advantages, understanding the environmental burden of CLT manufacturing remains scarce. This study uses input–output analysis to evaluate the greenhouse gas (GHG) emissions from CLT manufacturing. An extended input–output table was created to measure the GHG emissions by investigating the revenue and expenditure data of the largest CLT manufacturers in Japan in 2020, combined with the energy and emission intensity data. The results showed that electricity, activities not elsewhere classified, road freight transportation (except self-transportation), timber, and logs were the main sectors contributing to GHG emissions from CLT manufacturing. In addition, the environmental burdens of the cement and steel sectors were evaluated for comparison with the same increase in the final demand. We found that CLT manufacturing emits significantly fewer GHGs than the cement and steel sectors. These findings highlight the potential of CLT in reducing environmental burden, particularly in construction and civil engineering, emphasizing the importance of renewable energy use and efficient raw material transportation