3 research outputs found
Animal infection models using nonâmammals
The use of nonâhuman animal models for infection experiments is important for investigating the infectious processes of human pathogenic bacteria at the molecular level. Mammals, such as mice and rabbits, are also utilized as animal infection models, but large numbers of animals are needed for these experiments, which is costly, and fraught with ethical issues. Various nonâmammalian animal infection models have been used to investigate the molecular mechanisms of various human pathogenic bacteria, including Staphylococcus aureus, Streptococcus pyogenes, and Pseudomonas aeruginosa. This review discusses the desirable characteristics of nonâmammalian infection models and describes recent nonâmammalian infection models that utilize Caenorhabditis elegans, silkworm, fruit fly, zebrafish, twoâspotted cricket, hornworm, and waxworm