First observations with a GNSS antenna to radio telescope interferometer

We describe the design of a radio interferometer composed of a Global Navigation Satellite Systems (GNSS) antenna and a Very Long Baseline Interferometry (VLBI) radio telescope. Our eventual goal is to use this interferometer for geodetic applications including local tie measurements. The GNSS element of the interferometer uses a unique software-defined receiving system and modified commercial geodetic-quality GNSS antenna. We ran three observing sessions in 2022 between a 25 m radio telescope in Fort Davis, Texas (FD-VLBA), a transportable GNSS antenna placed within 100 meters, and a GNSS antenna placed at a distance of about 9 km. We have detected a strong interferometric response with a Signal-to-Noise Ratio (SNR) of over 1000 from Global Positioning System (GPS) and Galileo satellites. We also observed natural radio sources including Galactic supernova remnants and Active Galactic Nuclei (AGN) located as far as one gigaparsec, thus extending the range of sources that can be referenced to a GNSS antenna by 18 orders of magnitude. These detections represent the first observations made with a GNSS antenna to radio telescope interferometer. We have developed a novel technique based on a Precise Point Positioning (PPP) solution of the recorded GNSS signal that allows us to extend integration time at 1.5 GHz to at least 20 minutes without any noticeable SNR degradation when a rubidium frequency standard is used.Comment: 33 pages, 19 figure

Hyper-arid tall shrub species have differing long-term responses to browsing management

© 2019, © 2019 Taylor & Francis Group, LLC. Hyper-arid rangeland vegetation is typically dominated by large woody species which are often overlooked in herbivory studies. Long-term responses of tall shrub populations to herbivory change are poorly understood in the Arabian Peninsula. Population and size of 1559 individuals from four shrub species were assessed over an 11-year period under two herbivory regimes, one in which domestic livestock (camels) were replaced by semi-wild ungulates (Oryx and gazelles) before, and the other during, the study period. Each shrub species exhibited a different response to the change in herbivory. Populations of Calotropis procera decreased dramatically. Populations of both Calligonum polygonoides and Lycium shawii increased through sexual reproduction, but the spatial distribution of recruits indicated different modes of seed dispersal. Average lifespans were estimated at 22 and 20years respectively. The persistence strategy of Leptadenia pyrotechnica was similar to tree species of this habitat in that vegetative regrowth was prioritized over recruitment, and average lifespan was estimated at 95years. Shrub responses to changes in ungulate management are therefore species-specific. The response of individual plant size was faster than the response of population size, which was limited by slow sexual recruitment (L. pyrotechnica) or localized seed dispersal (C. polygonoides)

Communities, psychotherapeutic innovation and the diversity of international qualitative research in mental health

The articles in this special issue are hugely varied in terms of their country of origin (Brazil, Finland, Italy, Malaysia and the UK); theoretical influences (e.g. Lacanian theory, cultural-historical approaches and relational theories) and method of qualitative analysis (e.g. content and thematic analyses, Lacanian discourse analysis, Grounded theory, ethnography and auto-ethnography). In this commentary, I will discuss each article in turn before moving on to address some common issues including: the relationship between therapeutic innovation and research; differing implicit models of subjectivity; the need for theoretically pluralistic approaches to interpretation; and the need to incorporate the views of service users

Identification of Combinatorial Patterns of Post-Translational Modifications on Individual Histones in the Mouse Brain

Post-translational modifications (PTMs) of proteins are biochemical processes required for cellular functions and signalling that occur in every sub-cellular compartment. Multiple protein PTMs exist, and are established by specific enzymes that can act in basal conditions and upon cellular activity. In the nucleus, histone proteins are subjected to numerous PTMs that together form a histone code that contributes to regulate transcriptional activity and gene expression. Despite their importance however, histone PTMs have remained poorly characterised in most tissues, in particular the brain where they are thought to be required for complex functions such as learning and memory formation. Here, we report the comprehensive identification of histone PTMs, of their combinatorial patterns, and of the rules that govern these patterns in the adult mouse brain. Based on liquid chromatography, electron transfer, and collision-induced dissociation mass spectrometry, we generated a dataset containing a total of 10,646 peptides from H1, H2A, H2B, H3, H4, and variants in the adult brain. 1475 of these peptides carried one or more PTMs, including 141 unique sites and a total of 58 novel sites not described before. We observed that these PTMs are not only classical modifications such as serine/threonine (Ser/Thr) phosphorylation, lysine (Lys) acetylation, and Lys/arginine (Arg) methylation, but also include several atypical modifications such as Ser/Thr acetylation, and Lys butyrylation, crotonylation, and propionylation. Using synthetic peptides, we validated the presence of these atypical novel PTMs in the mouse brain. The application of data-mining algorithms further revealed that histone PTMs occur in specific combinations with different ratios. Overall, the present data newly identify a specific histone code in the mouse brain and reveal its level of complexity, suggesting its potential relevance for higher-order brain functions