Association between high-sensitivity C-reactive protein and lipid profile in patients with type 2 diabetes mellitus

Background: The most significant and challenging health issue of the modern era is diabetes mellitus and its complications. Inflammation plays a crucial role in the development and progression of diabetes. Type 2 Diabetes Mellitus patients(T2DM) are at significant risk of developing cardiovascular diseases. High-sensitive CRP (hs-CRP) has become a reliable indicator of low-grade inflammation. Since very little is known regarding the relationship between hs-CRP and T2DM, the goal of this study was to evaluate hs-CRP levels and lipid profile and to study their relationship to cardiovascular problems in Type 2 Diabetes Mellitus patients. Material and Methods: The current study was carried out at Index Medical College and Hospital in Indore. The study group consisted of 70 healthy controls and 70 Type 2 Diabetes Mellitus patients who had been diagnosed following WHO criteria. Serum hs-CRP concentrations as well as the lipid profile (total cholesterol, HDL, and TG) were assessed. SPSS version 26 was used to analyze the data. Results: In comparison to controls, individuals with Type 2 Diabetes Mellitus had significantly higher levels of hs-CRP, with a mean value of 2.49 + 1.15 mg/L (p <0.001).&nbsp

The associations between serum dihydrotestosterone levels, lipid parameters & anthropometric measurements in male patients with type 2 diabetes mellitus

Background: Male fertility is affected by the metabolic and hormonal dysregulation brought on by Diabetes Mellitus, a metabolic illness, particularly in the hypothalamus-pituitary testicular axis. However, there is little proof that endocrinopathy causes diabetic men's infertility and low testosterone levels. It is well established that Type 2 Diabetes causes dyslipidemia & obesity by lowering serum testosterone levels. However, there isn't much research on DHT, the most potent androgen, and its relationship to male lipid profiles. Methods:  The study was carried out at Teerthanker Mahaveer Medical College and Research Centre, Moradabad, in the Department of Physiology and Medicine & Department of Physiology Santosh Medical College, Ghaziabad. A total of 210 samples—105 from type 2 diabetics and 105 from controls—were included in the study. Using conventional biochemical techniques, Lipid parameters [HDL, LDL, VLDL &TC], serum DHT, Data analysis was done with SPSS 26. [ trial version]. Results: The levels of serum dihydrotestosterone were significantly lower in diabetic cases than in healthy controls [439.26 ± 257.87pg/ml vs 230.66 ± 182.02pg/ml, p=0.001]. 90 percent of Type 2 diabetics were found to have subnormal levels, as opposed to just 10 percent of controls.&nbsp

The utilisation of cardiac risk ratio and non-HDL cholesterol markers to assess cardiovascular risk in type 2 diabetes males with lowered serum DHT

Background A risk factor for cardiovascular disease, particularly vascular disease when linked to Diabetes Mellitus, is the decline of male sex androgens. In recent years, many forms of studies have been conducted to confirm its link. Male hypogonadism is linked to dyslipidemia, visceral obesity, and CVD disorders. Testosterone's role in Type 2 Diabetes has been researched alone or in conjunction with Sex hormone binding globulin. DHT, the most recent androgen to be discovered whose functions are being researched and elaborated upon, hasn't received much attention. Very little research has been conducted in India and Asia that looked at androgens associations with cardiac risk indicators. Methods:  The study was carried out at Teerthanker Mahaveer Medical College and Research Centre's Department of Physiology and Medicine and Santosh Medical College's Department of Physiology in Moradabad and Ghaziabad, respectively. A total of 210 samples, including 105 from type 2 diabetes and 105 from controls, were used in the investigation. Lipid parameters [HDL, LDL, VLDL & TC], serum DHT, and data analysis were performed using the conventional biochemical methods and SPSS 26 (trial version).

Neutralizing IgG antibody seroprevalence, efficacy and safety post covishield vaccination: A follow up study

COVID-19, a pandemic caused by severe acute respiratory syndrome  (SARS) corona virus-2 has been a worldwide challenge for the entire mankind. However, a safe and efficacious vaccine would be clinically valuable to reduce the risks of COVID-19. In this study, we aimed to assess the seroprevalence of the Neutralizing IgG Antibodies six months after completion of both the doses of Covishield Vaccination (ChAdox1 nCoV-19) and compare it with the IgG titres one month after the first dose and one month after the second dose of the vaccine respectively. The efficacy, safety and comorbidities related to the vaccine were also assessed at different time intervals. The levels of IgG antibodies were estimated in 72 subjects from the Teerthanker Mahaveer Medical College & Research Centre (who turned up after six months of the complete regimen of Covishield Vaccination) using the Enzyme-Linked Immunosorbent Assay (ELISA) Technique. A highly significant increase (p= 0.00) in the neutralizing Antibodies titre was seen in fully vaccinated individuals post six months when compared to the titres of post one month of 1st & 2nddoses. It can therefore be concluded that (ChAdox1 nCoV-19) Covishield Vaccination if administered in full regimen has both acceptable efficacies as well as safety profile.&nbsp