Early detection of cerebral berry aneurysms using 3D Volume Rendering in In vivo 5

Forensic Radiology is currently an integral part of the preliminary procedure of post-mortem examination. As a time and cost-effective measure, a routine medical imaging scan is conducted prior to the autopsy. A commonly encountered cause of death in victims is a subarachnoid haemorrhage which often occurs as a result of a cerebral aneurysm. The key characteristics of cerebral aneurysms involve a weak, bulging artery in the brain that occurs randomly and with no discernible symptoms. The aneurysm may rupture abruptly resulting in brain damage or death. The three current methods of analysis of a Cerebral Aneurysm include Digital Subtraction Angiography, Computer Tomography Angiography and Magnetic Resonance Angiography – all three of which have unique limitations that can be overcome by a software called Invivo 5 by Anatomage. Invivo 5 allows for three-dimensional volume reconstruction and visualization of anatomy not easily seen on standard medical scans. It is a much more effective method to detect Cerebral Aneurysms in their earliest stage when they are smaller than 5mm in diameter and cannot be located on CT scans or MRI’s. This research experiment evaluates the difference in detection of Intercranial Aneurysms with Invivo 5 versus a traditional X-ray in a non-invasive manner. It promises a forensically useful way to verify a cause of death as a result of an aneurysm or disqualify this disease allowing for other possible reasons for death

Neonatal haemolytic disease with co-existing Anti-D and Anti-C antibodies: an unusual experience

Neonatal haemolytic disease in the new-born remains of prime importance for paediatricians due to high perinatal morbidity and mortality rates. The Rh antigen family comprises several different antigens, out of which, D antigen incompatibility is well known for causing severe haemolytic disease in the foetus. Although the current literature shows anomalous cases where coexisting non-D-Rh and D-Rh antigens are the causative agents, there is very little information regarding post-natal outcomes in neonates bearing two different incompatibilities simultaneously. Herein, we discuss an unusual case of anti-D as well as anti-C antibodies (non-D-Rh) in a male neonate born to a Rh-negative mother, who developed jaundice and haemolysis in post-natal life. The neonate underwent exchange transfusion and photo therapy due to raised serum bilirubin levels, supplemented with repeated blood transfusions, intravenous immunoglobulin therapy, and immunosuppressive therapy. --Continu