Sind Äpfel doch mit Birnen vergleichbar? : Standardisierung von Nutzungsstatistiken durch COUNTER

Ziel ist, den Wissenschaftlern und Bibliothekaren zu erklären, zu was Counter (Counting Online Usage of Networked Electronic Resources) dient, was Counter aussagt

Akzeptanz und Nutzung von E-Books: eine Literaturstudie

Der Beitrag gibt einen Überblick über die bisher vorliegenden Studien zu Nutzung und Akzeptanz von E-Books und bewertet deren Ergebnisse nach inhaltlichen und methodischen Aspekten

The Efficacy of Simulation as a Pedagogy in Facilitating Pre-Service Teachers’ Learning About Emotional Self-Regulation and its Relevance to the Teaching Profession

This study was undertaken in response to the imperative of teacher education courses incorporating National Professional Standards for Teachers, in particular Standard 7, which deals with the professional engagement of teachers (AITSL, 2011). It aimed to evaluate the efficacy of simulation and active recall as a learner-centred pedagogy in facilitating pre-service teachers’ learning about their capacity to self-regulate emotionally and its relevance to the profession. A simulated ‘critical incident’ was used in a lecture to guide students (n=106) to analyse and understand their emotional responses to an altercation between the lecturer and a colleague. The evaluation involved both quantitative and qualitative data collection. The study generated six useful insights associated with the efficacy of simulation pedagogy and revealed convincingly that this pedagogy can engage students actively in learning about the importance of emotional self-regulation in relation to their professional role as a teacher

Invasiveness of plant pathogens depends on the spatial scale of host distribution

Plant diseases often cause serious yield losses in agriculture. A pathogen’s invasiveness can be quantified by the basic reproductive number, R₀. Since pathogen transmission between host plants depends on the spatial separation between them, R₀ is strongly influenced by the spatial scale of the host distribution.We present a proof of principle of a novel approach to estimate the basic reproductive number, R₀, of plant pathogens as a function of the size of a field planted with crops and its aspect ratio. This general approach is based on a spatially explicit population dynamical model. The basic reproductive number was found to increase with the field size at small field sizes and to saturate to a constant value at large field sizes. It reaches a maximum in square fields and decreases as the field becomes elongated. This pattern appears to be quite general: it holds for dispersal kernels that decrease exponentially or faster, as well as for fat-tailed dispersal kernels that decrease slower than exponential (i.e., power-law kernels).We used this approach to estimate R₀ in wheat stripe rust (an important disease caused by Puccinia striiformis), where we inferred both the transmission rates and the dispersal kernels from the measurements of disease gradients. For the two largest datasets, we estimated R₀ of P. striiformis in the limit of large fields to be of the order of 30. We found that the spatial extent over which R₀ changes strongly is quite fine-scaled (about 30 m of the linear extension of the field). Our results indicate that in order to optimize the spatial scale of deployment of fungicides or host resistances, the adjustments should be made at a fine spatial scale. We also demonstrated how the knowledge of the spatial dependence of R₀ can improve recommendations with regard to fungicide treatment.This is the publisher’s final pdf. The article is published by John Wiley & Sons, Inc. and copyrighted by the Ecological Society of America. It can be found at: http://esajournals.onlinelibrary.wiley.com/hub/journal/10.1002/%28ISSN%291939-5582/Keywords: dispersal, population dynamics, epidemiology, disease control, spatial scales, host-pathogen interaction, disease gradient, plant disease, mathematical model, basic reproductive numbe

Foresight in clinical proteomics: current status, ethical considerations, and future perspectives

With the advent of robust and high-throughput mass spectrometric technologies and bioinformatics tools to analyze large data sets, proteomics has penetrated broadly into basic and translational life sciences research. More than 95% of FDA-approved drugs currently target proteins, and most diagnostic tests are protein-based. The introduction of proteomics to the clinic, for instance to guide patient stratification and treatment, is already ongoing. Importantly, ethical challenges come with this success, which must also be adequately addressed by the proteomics and medical communities. Consortium members of the H2020 European Union-funded proteomics initiative: European Proteomics Infrastructure Consortium-providing access (EPIC-XS) met at the Core Technologies for Life Sciences (CTLS) conference to discuss the emerging role and implementation of proteomics in the clinic. The discussion, involving leaders in the field, focused on the current status, related challenges, and future efforts required to make proteomics a more mainstream technology for translational and clinical research. Here we report on that discussion and provide an expert update concerning the feasibility of clinical proteomics, the ethical implications of generating and analyzing large-scale proteomics clinical data, and recommendations to ensure both ethical and effective implementation in real-world applications

Silencing and Nuclear Repositioning of the λ5 Gene Locus at the Pre-B Cell Stage Requires Aiolos and OBF-1

The chromatin regulator Aiolos and the transcriptional coactivator OBF-1 have been implicated in regulating aspects of B cell maturation and activation. Mice lacking either of these factors have a largely normal early B cell development. However, when both factors are eliminated simultaneously a block is uncovered at the transition between pre-B and immature B cells, indicating that these proteins exert a critical function in developing B lymphocytes. In mice deficient for Aiolos and OBF-1, the numbers of immature B cells are reduced, small pre-BII cells are increased and a significant impairment in immunoglobulin light chain DNA rearrangement is observed. We identified genes whose expression is deregulated in the pre-B cell compartment of these mice. In particular, we found that components of the pre-BCR, such as the surrogate light chain genes λ5 and VpreB, fail to be efficiently silenced in double-mutant mice. Strikingly, developmentally regulated nuclear repositioning of the λ5 gene is impaired in pre-B cells lacking OBF-1 and Aiolos. These studies uncover a novel role for OBF-1 and Aiolos in controlling the transcription and nuclear organization of genes involved in pre-BCR function

Benchmarking user satisfaction in academic libraries - a case study

Customer satisfaction and service quality have so far been evaluated mostly from a local perspective although the quality element has been firmly established in academic library management for at least a decade. Critics of inter-institutional comparisons often object that different preconditions are not considered adequately. Examples from a joint user satisfaction survey conducted by 15 German university libraries in 2001 suggest that comparative data are a suitable means to identify cases of “best practice” and can effectively initialize processes of customer-focussed improvement. Furthermore, if compared with corresponding statistical data or performance measures, satisfaction ratings can reveal possible structural strengths and deficits relative to other libraries. On the other hand, follow-up telephone interviews with participating libraries showed that the survey results substantially challenged the institutions’ internal communication and public relations organisation, and underlined that even in a well-developed culture of assessment the need for professional mediation and coordination of comparative analyses may not be underestimated

Ergebnisse der Befragung zur Kundenzufriedenheit mit dem BSZ. Vortragsfolien vom 8. BSZ-Kolloquium am 04./05. Oktober 2007 in Konstanz

Inhalt: - Auftrag und Rahmenbedingungen - Inhalt und Struktur des Fragebogens - Rücklauf: Herkunft der Teilnehmer - Portfolio der Hauptdienstleistungen - Erstes Fazit - Identifikation von Kundengruppen - Portfolio nach Zielgruppen - Detailaussagen zur Online-Fernleihe - Wesentliche Bewertungen und Kommentare - Allgemeine Serviceorientierung - Fazit und Diskussionsansätz