5,580 research outputs found
Mm-wave power meter mount
E-band thermistor mount and a technique for adjusting a temperature compensating thermistor to provide an electrically balanced bridge are used for measuring RF power in the mm-wavelength. The mount is relatively insensitive to temperature effects that cause measurement errors in single ended circuits
Matched Thermistors for Microwave Power Meters-Patent
Matched thermistors for microwave power meters with compensation for temperature change
A combinatorial approach of Proteomics and Systems Biology in unravelling the mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in murine AKI
BACKGROUND: Acute kidney injury (AKI) is a frequent condition in hospitalised patients undergoing major surgery or the critically ill and is associated with increased mortality. Based on the volume of the published literature addressing this condition, reporting both supporting as well as conflicting molecular evidence, it is apparent that a comprehensive analysis strategy is required to understand and fully delineate molecular events and pathways which can be used to describe disease induction and progression as well as lead to a more targeted approach in intervention therapies.<p></p>
RESULTS: We used a Systems Biology approach coupled with a de-novo high-resolution proteomic analysis of kidney cortex samples from a mouse model of folic acid-induced AKI (12 animals in total) and show comprehensive mapping of signalling cascades, gene activation events and metabolite interference by mapping high-resolution proteomic datasets onto a de-novo hypothesis-free dataspace. The findings support the involvement of the glutamatergic signalling system in AKI, induced by over-activation of the N-methyl-D-aspartate (NMDA)-receptor leading to apoptosis and necrosis by Ca2+-influx, calpain and caspase activation, and co-occurring reactive oxygen species (ROS) production to DNA fragmentation and NAD-rundown. The specific over-activation of the NMDA receptor may be triggered by the p53-induced protein kinase Dapk1, which is a known non-reversible cell death inducer in a neurological context. The pathway mapping is consistent with the involvement of the Renin-Angiotensin Aldosterone System (RAAS), corticoid and TNFalpha signalling, leading to ROS production and gene activation through NFkappaB, PPARgamma, SMAD and HIF1alpha trans-activation, as well as p53 signalling cascade activation. Key elements of the RAAS-glutamatergic axis were assembled as a novel hypothetical pathway and validated by immunohistochemistry.<p></p>
CONCLUSIONS: This study shows to our knowledge for the first time in a molecular signal transduction pathway map how AKI is induced, progresses through specific signalling cascades that may lead to end-effects such as apoptosis and necrosis by uncoupling of the NMDA receptor. Our results can potentially pave the way for a targeted pharmacological intervention in disease progression or induction.<p></p>
Surface Flow Structure of the Gulf Stream From Composite Imagery and Satellite-Tracked Drifters
A unique set of coutemporaneous satellite-tracked drifters and five-day composite Advanced Very High Resolution Radionmeter (AVHRR) satellite imagery of the North Atlantic has been analyzed to examine the surface flow structure of the Gulf Stream. The study region was divided into two sections, greater than 37 degrees N and less than 37 degrees N, in order to answer the question of geographic variability. Fractal and spectral analyses methods were applied to the data. Fractal analysis of the Lagrangian trajectories showed a fractal dimension of 1.21 +/- 0.02 with a scaling range of 83 - 343 km. The fractal dimension of the temperature fronts of the composite imagery is similar for the two regions with D = 1.11 +/- 0.01 over a scaling range of 4 - 44 km. Spectral analysis also reports a fairly consistent value for the spectral slope and its scaling range. Therefore, we conclude there is no geographic variability in the data set. A suitable scaling range for this contemporaneous data set is 80 - 200 km which is consistent with the expected physical conditions in the region. Finally, we address the idea of using five-day composite imagery to infer the surface flow of the Gulf Stream. Close analyses of the composite thermal fronts and the Lagrangian drifter trajectories show that the former is not a good indicator of the latter
Numerical modeling of multidimensional flow in seals and bearings used in rotating machinery
The rotordynamic behavior of turbomachinery is critically dependent on fluid dynamic rotor forces developed by various types of seals and bearings. The occurrence of self-excited vibrations often depends on the rotor speed and load. Misalignment and rotor wobbling motion associated with differential clearance were often attributed to stability problems. In general, the rotative character of the flowfield is a complex three dimensional system with secondary flow patterns that significantly alter the average fluid circumferential velocity. A multidimensional, nonorthogonal, body-fitted-grid fluid flow model is presented that describes the fluid dynamic forces and the secondary flow pattern development in seals and bearings. Several numerical experiments were carried out to demonstrate the characteristics of this complex flowfield. Analyses were performed by solving a conservation form of the three dimensional Navier-Stokes equations transformed to those for a rotating observer and using the general-purpose computer code PHOENICS with the assumptions that the rotor orbit is circular and that static eccentricity is zero. These assumptions have enabled a precise steady-state analysis to be used. Fluid injection from ports near the seal or bearing center increased fluid-film direct dynamic stiffness and, in some cases, significantly increased quadrature dynamic stiffness. Injection angle and velocity could be used for active rotordynamic control; for example, injection, when compared with no injection, increased direct dynamic stiffness, which is an important factor for hydrostatic bearings
Peat Resources of Maine - Volume 4: Southern and Western Maine
Peat Resources of Maine - Volume 4: Southern and Western Maine
by Cornelia C. Cameron, Michael K. Mullen, Carolyn A. Lepage & Walter A. Anderson
Bulletin 31 - Maine Geological Survey, Department of Conservation, Augusta, Maine (1984).
Preparation of this report was supported by funds furnished by the U.S. Department of Energy, Grant No. DE-FG18-79ET14690, the Maine Office of Energy Resources, the Maine Geological Survey, and the U.S. Geological Survey.
Contents: Introduction / The Maine Peat Resource Evaluation Program / Geologic Setting of Maine Peat Deposits / Formation of Peat Deposits in Maine / Methods of Investigation / Identification of Maine Peat Resources / Peat Resources in Southern and Western Maine / Acknowledgements / Referenceshttps://digitalcommons.usm.maine.edu/me_collection/1190/thumbnail.jp
Geometrical Defects in Josephson Junction Arrays
Dislocations and disclinations in a lattice of Josephson junctions will
affect the dynamics of vortex excitations within the array. These defects
effectively distort the space in which the excitations move and interact. The
interaction energy between such defects and excitations are determined and
vortex trajectories in twisted lattices are calculated. Finally, possible
experiments observing these effects are presented.Comment: 26 pages including 5 figure
First Principles Analysis of Electron-Phonon Interaction in Graphene
The electron-phonon interaction in monolayer graphene is investigated by
using density functional perturbation theory. The results indicate that the
electron-phonon interaction strength is of comparable magnitude for all four
in-plane phonon branches and must be considered simultaneously. Moreover, the
calculated scattering rates suggest an acoustic phonon contribution that is
much weaker than previously thought, revealing the role of optical phonons even
at low energies. Accordingly it is predicted, in good agreement with a recent
measurement, that the intrinsic mobility of graphene may be more than an order
of magnitude larger than the high values reported in suspended samples.Comment: 12 pages, 4 figure
Macroscopic Quantum Tunnelling in Rotating Bose-Einstein Condensates
In this paper we investigate the macroscopic quantum tunnelling and the phase
coherence property of the rotating Bose-Einstein condensates in both static and
dynamic cases by using the mean field theory.Comment: 10 pages, 1 figure, submitted to Phys.Rev.
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