56 research outputs found
Effect of Adalimumab on Work Productivity and Indirect Costs in Moderate to Severe Crohn’s Disease: A Meta-Analysis
peer reviewedOBJECTIVE: To assess the effect of adalimumab on work productivity and indirect costs in patients with Crohn's disease (CD) using a meta-analysis of clinical trials. METHODS: Study-level results were pooled from all clinical trials of adalimumab for moderate to severe CD in which work productivity outcomes were evaluated. Work Productivity and Activity Impairment Questionnaire outcomes (absenteeism, presenteeism and total work productivity impairment [TWPI]) were extracted from adalimumab trials. Meta-analyses were used to estimate pooled averages and 95% CIs of one-year accumulated reductions in work productivity impairment with adalimumab. Pooled averages were multiplied by the 2008 United States national average annual salary (3,856 (4,529) and 8,833 to $13,096), respectively. CONCLUSION: Adalimumab provided clinically meaningful improvements in work productivity among patients with moderate to severe CD, which may translate into substantial indirect cost savings from an employer's perspective
Nomenclature and Traceability Debate for Biosimilars: Small-Molecule Surrogates Lend Support for Distinguishable Nonproprietary Names
Greater refill adherence to adalimumab therapy for patients using specialty versus retail pharmacies
Mo1254 Reduction in Colectomy- and Health Care-Related Costs in Ulcerative Colitis Patients Treated With Adalimumab Compared With Standard Therapy
S1040 Dosage Pattern of Adalimumab in Real-World Clinical Practice and Predictors of Dosage Increase in Patients with Crohn's Disease in the US
S1062 Remission and Quality-of-Life Improvements Sustained with Adalimumab in Anti-TNF-Naïve Patients with Crohn's Disease: 3-Year Data from CHARM
S1057 Improvements in Work Productivity and Quality of Life in Adalimumab-Treated Patients with Crohn's Disease: the Care Trial
1099 A Retrospective Study of Colectomy Complications and Their Associated Costs for Patients With Ulcerative Colitis
T1315 Crohn's Disease Duration is Associated With Increased Health Care Resource Utilization and Comorbidity Development
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