The Uniqueness of Achatina fulica in its Evolutionary Success

The increasing load of environmental pollutants poses a serious threat over the globe. In this vulnerable situation, it is essential to have alternative sources of medicines, may be from invertebrates. Among invertebrates, although molluscs are known for their consumption as food and ethno‐medicinal use, the importance of these animals is still overlooked. Presently attention has been geared toward molluscs including Achatina fulica which are now considered as one of the most evolutionary successful animals. During the last few decades, researchers are trying to decipher their complex immune system to harvest valuable molecules to treat human diseases. In the present review, the existence of important immunological factors in Achatina is discussed addressing the coagulation system, innate immune molecules, bioactive proteins and lastly the enigmatic C‐reactive proteins

The Discrete Voronoi game in ℝ\u3csup\u3e2\u3c/sup\u3e

In this paper we study the last round of the discrete Voronoi game in ℝ2, a problem which is also of independent interest in competitive facility location. The game consists of two players P1 and P2, and a finite set U of users in the plane. The players have already placed two disjoint sets of facilities F and S, respectively, in the plane. The game begins with P1 placing a new facility followed by P2 placing another facility, and the objective of both the players is to maximize their own total payoffs. In this paper we propose polynomial time algorithms for determining the optimal strategies of both the players for arbitrarily located existing facilities F and S. We show that in the L1 and the L∞ metrics, the optimal strategy of P2, given any placement of P1, can be found in O(n log n) time, and the optimal strategy of P1 can be found in O(n5 log n) time. In the L2 metric, the optimal strategies of P2 and P1 can be obtained in O(n2) and O(n2) and O(n8) times, respectively

IN VITRO ANTI-DIABETIC AND ANTI-OXIDANT ACTIVITIES OF ETHANOL EXTRACT OF TINOSPORA SINENSIS

Objective: The aim of the present study was to evaluate the alpha (α)-amylase and alpha (α)-glucosidase inhibitory activities and in vitro antioxidant activities of the 80 % aqueous ethanol extracts of Tinosporasinensis Lour (Merr.).Methods: The 80% aq. ethanol extract of the plant was prepared. The plant extract was examined for its antioxidant activity by using free radical 1,1-diphenyl-2-picryl hydrazyl (DPPH) scavenging method, ABTS radical scavenging ability, reducing power capacity, estimation of total phenolic content, flavonoid content and flavonol content. Different concentrations (2, 4, 8,10and 15 μg/ml) of the extract was subjected to α-amylase inhibitory and α-glucosidase inhibitory activities and IC50were calculated.Results: The study revealed that the different concentrations of the plant extract possessed a very good amount of total phenolics, flavonoid and flavonol and exhibited potent radical scavenging activity using DPPH and ABTS as a substrate. The ethanol extracts exhibited significant α-amylase and α-glucosidase inhibitory activities with an IC50 value1.093µg and 1.04µg dry extract respectively and well compared with standard acarbose drug.Conclusion: Thus, it could be concluded that due to the presence of antioxidant components the plant extracts could be used for the treatment of hyperglycemia, diabetes and the related condition of oxidative stress. This knowledge will be useful in finding more potent components from the natural resources for the clinical development of antidiabetic therapeutics