1 research outputs found
Genipin-crosslinked gelatin scaffold in tissue engineering: a systematic review
Gelatin has been frequently used in tissue engineering scaffold due to its favorable biological properties in wound healing enhancement. Genipin, a natural
compound derived from Gardenia plants, was shown to be effective in improving
physicochemical characteristics of the gelatin scaffold. This systematic review
reported the utility of genipin as a crosslinker in gelatin scaffold fabrication. Two
electronic databases, namely Scopus and MEDLINE via Ebcoshost were searched
for publication between January 1999 and December 2018, using the keywords
‘gelatin’ and ‘genipin’. Articles published in English, reporting the utility of genipin
in the fabrication of gelatin sponge were included. The keywords search yielded
830 articles, in which 14 articles were selected and examined in this review.
The result of the search provided input in terms of the optimum concentration,
crosslinking temperature, and fabrication method of genipin to be used. From the
literature, it was found that 0.5% is the optimum genipin concentration and 25ËšC
is the optimum crosslinking temperature. The result also revealed a gap in the
knowledge regarding genipin crosslinker and justifies the need to create awareness
of the utility of genipin as a gelatin scaffold crosslinker. The current review provides
an extensive overview on the current knowledge on genipin crosslinking and be a
guide to an optimal fabrication of the genipin-crosslinked gelatin scaffold