Lefort 1 Access for Juvenile Nasopharyngeal Angiofibroma Treated Without Angiographic Embolization.

To assess and analyze the clinical presentation of Juvenile nasopharyngeal angiofibroma and analyze the complications associated with JNA resection without pre surgical embolization using LeFort 1

GMO/GMF on Social Media in China: Jagged Landscape of Information Seeking and Sharing Behavior through a Valence View

The study examines the critical factors affecting Chinese social media (SM) users’ intentions and behavior to seek and share information on genetically modified organisms/ genetically modified food (GMO/GMF). The proposed framework was conceptualized through benefit-risk analysis and subsequently mapped SM users’ perceived benefits and risks to seeks and share information using Kurt Lewin’s valence view. Quantitative data was collected using survey questionnaires administered from 583 SM users. The results of the path analysis demonstrated two key findings related to SM users’ perceived benefits and risks to seek and share information on GMO/GMF. Among risks, the psychological risk is the strongest predictor of perceived risk to use SM for GMO/GMF, which consequently determines the intentions and behaviors to share information about GMO/GMF on SM in People’s Republic of China. Among benefits, the results showed that perceived usefulness, creditability of GMO/GMF information, and information support are positively related to perceived benefits to use SM for GMO/GMF, which subsequently, predicts the intentions and behaviors to seek information about GMO/GMF on SM. This study suggests scholars and practitioners explore and utilize the efficient communication strategy to fulfill the potential of the SM to increase GMO/GMF acceptance in Chinese society

Inhibitory Effect of Sodium Cromoglycate on Insulin Induced Airway Hyper-Reactivity

Objective: To explore the acute effect of insulin on airway reactivity of guinea pigs and protective effects of sodium cromoglycate against insulin induced airway hyper-reactivity on isolated tracheal tissues of guinea pigs in vitro. Subjects and Methods: Effects of insulin (10-7- 10-3 M) and insulin pretreated with sodium cromoglycate (10-6 M) were observed on isolated tracheal strip of guinea pig (n=12) in vitro by constructing cumulative concentration response curves. The tracheal smooth muscle contractions were recorded with Transducer on Four Channel Oscillograph. Results: Insulin produced a concentration dependent reversible contraction of isolated tracheal muscle of guinea pig. The mean ± SEM of maximum amplitudes of contraction with insulin and insulin pretreated with sodium cromoglycate were 35 ± 1.13 mm and 14.55 ± 0.62 mm respectively. Cromoglycate shifted the concentration response curve of insulin to the right and downwards. Conclusion: Sodium cromoglycate significantly reduced the insulin mediated airway hyper-reactivity in guinea pigs. So we suggest that pretreatment of inhaled insulin with cromoglycate may have clinical implication in amelioration of its potential respiratory adverse effects such as bronchoconstriction

Management of Fournier’s Gangrene; A Randomized Controlled Trial at High Volume Center Comparing the Efficacy of Honey and Eusol Dressing in Wound Healing

OBJECTIVE: To assess the effectiveness of honey dressing in Fournier’s Gangrene against conventional Edinburgh University solution of lime (EUSOL) dressing. METHODOLOGY: This was a prospective experimental study conducted in Liaquat National Medical College and Hospital Karachi for duration of 5 and half years. Total 44 patients having gangrene and no co morbid conditions were included in this study. Patients who had co-morbid conditions like deranged coagulation profile and CVA, who were not willing to participate or loss to follow up were excluded from the study. After getting baseline blood workup (i.e. CBC, S. Creatinine, S. Electrolytes, Urine D/R, C/S and Diabetic workup) done and taking consent, the patients were immediately shifted to operation theatre, the incision and drainage was performed, and the necrotic tissues were debrided. Pus cultures were sent, and patients were started on routine intravenous antibiotics (3rd generation Cephalosporin and metronidazole). A Dressing of wound was done randomly by honey in Group A and by Eusol in Group B. Patients were discharged after wound was completely healed. The data were obtained and analyzed by using SPSS version 20. Mann-Whitney U-test and chi-square test was applied to find out the significance. RESUTS: The patients in Group A got slough cleared in4.82±0.96 days, on average requiring 3.22±0.75 number of debridement’s, complete wound healing and duration of hospital stay being 9.54±0.74 days. The patients in Group B got slough cleared in 8±0.87 days, requiring 5.32±0.72 number of debridement’s, complete wound healing and duration of hospital stay 13.68±1.09 days.There was a significant difference in slough clearance, number of debridement’s required, time taken for complete wound healing and hospital stay between Group A and Group B (P-value <0.001). CONCLUSION: This study predicted that honey is very valuable in the management of Fournier’s gangrene as it ensured early clearance of slough, required lesser number of debridement’s, had early wound healing and had relatively shorter duration of stay in hospital than those treated with conventional EUSOL as dressing material

Two-phase frictional pressure drop with pure refrigerants in vertical mini/micro-channels

Environmental concerns have urged a search for eco-friendly refrigerants in the refrigeration industry to overcome ozone depletion and global warming problems. Therefore, current research emphasizes frictional pressure drop during flow boiling of environment-friendly refrigerants (GWP\u3c150), isobutane, HFC-152a, HFO-1234yf were tested against commonly reported HFC-134a. The data presented here was collected under heat flux-controlled conditions; the test piece was a round tube (1.60 mm diameter). The data collection was performed at 27 and 32 °C with mass velocities in 50-500 kg/m2s range. Effects of critical controlling parameters, like heat flux, mass velocity, exit vapor quality, operating pressure and medium, were studied in detail. It was observed that pressure drop increases along with mass velocity increment in the test piece and increases with exit vapor quality increment. The same was noticed to decrease with saturation temperature increment. Parametric effects and prediction of assessment methods are reported

Electronic cigarettes consumption and associated factors among general population in Western Saudi Arabia

Background: In recent years, consumption of E-cigarettes has increased dramatically. Several studies have focused on the prevalence of E-cigarettes among specific groups of people, using it as a substitute to traditional cigarettes, or the participant knowledge regarding risks. This research was aimed on E-cigarettes’ prevalence and its association to several factors in the general population of Western Saudi Arabia. Design and Methods: Using an observational cross-sectional study, data were collected from (n=465) above 18 years old smokers during the survey at public attractions. A validated self-administered questionnaire acquired from previous studies was employed to insure the suitability for the general population of Jeddah Saudi Arabia. Sample size was calculated via Raosoft@ and adults of either gender were included in the study. Descriptive or inferential statistical analysis was performed using SPSS. Results: The preponderance of e-cigarette smokers used entertainment as the reason for smoking, with an average of (33.9%). Although one reason for e-cigarette consumption was to cease traditional smoking, results showed an average of (49.4%), which is the majority of those who attempted to cease traditional smoking via e-cigarette, did not succeed in quitting traditional smoking. This study also demonstrated that participant that believed that e-cigarette is beneficial had a higher chance to cease conventional smoking than who did not (32.1% versus 14.6%) which is significant (p<0.001). Conclusions: In conclusion, this study estimated the prevalence of e-cigarette consumption among the population of Jeddah, Saudi Arabia along with assessment of elements which help increase the overall e-cigarette consumption in Jeddah

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication