8 research outputs found

    Características clínicas y epidemiológicas de la escabiosis en tres consultorios del médico de la familia

    No full text
    Se estudiaron 67 pacientes con escabiosis de los consultorios 12,21 y 26 del Policlínico &laquo;Héroes del Corinthya&raquo; y se encontró una incidencia del 5,13 % con una frecuencia esperada de 22 casos anuales por consultorio. La enfermedad fue más frecuente entre las mujeres de 45 a 54 años y entre los obreros de nivel medio de escolaridad. Se identificaron lesiones elementales poco comunes y localizaciones no habituales de las lesiones para esta dermatosis. El mayor número de casos mejoró entre los 8 y los 14 días de implantadas las medidas de control para la enfermedad<br>67 patients affected by scabies who were cared for by family physicians’ consulting rooms No. 12, 21 and 26 of &laquo;Héroes del Corinthia&raquo; polyclinics were examined where 5.13 % of incidence and an expected frequency of 22 cases per year per consulting room were found. This disease was more frequently suffered by women aged 45 to 54 years and by medium educational level workers. Uncommon basic lesions and rare lesion locations for this kind of dermatosis were detected. The majority of cases recovered 8 to 14 days after adequate disease control measures being implemente

    Temporal trends of circulating nitric oxide and pro-inflammatory cytokine responses ex vivo in intra-abdominal sepsis: results from a cohort study.

    No full text
    OBJECTIVE AND DESIGN: To evaluate the association of pro-inflammatory mediators with organ dysfunction and adverse outcome in intra-abdominal sepsis patients. SUBJECTS: Twenty-one patients admitted to the Intensive Care Unit (ICU) were prospectively included in the study. Only patients with surgical diagnosis of intra-abdominal sepsis were enrolled. RESULTS: Tumor necrosis factor-alpha (TNFalpha) and interleukin (IL)-6 produced ex vivo were significantly lower in non-survivors on admission (p = 0.021) and day 2 (p = 0.013), respectively. Nitric oxide (NO( x )) levels were significantly higher in non-survivors from the onset of sepsis and until day 4 after diagnosis (p < 0.05). Circulating lymphocyte counts were lower in non-survivors after admission over time, but there was no association with impaired cytokine production in this group of patients during the entire follow-up. All non-survivors developed nosocomial pneumonia concomitantly with multiple organ dysfunction and septic shock. There was a significant correlation between nitric oxide (NO( x )) concentrations and the sequential organ failure assessment (SOFA) score at day 2 (r = 0.598, p = 0.009), and ICU stay (r = 0.605, p = 0.006). Continuously high NO( x ) levels correlated with organ failure. The pro-inflammatory mediators TNFalpha, IL-6 and NO( x ), and also the Simplified Acute Physiology Score II (SAPS-II), discriminate survivors from non-survivors. According to logistic regression models, although these parameters are independently associated with the outcome, they do not improve the predictive power of the SAPS-II score for mortality risk. CONCLUSIONS: Disturbances in inflammatory responses and increase in NO( x ) generation seem to characterize early intra-abdominal sepsis, in which immune suppression is associated with an increased susceptibility to nosocomial infections. Sequential NO( x ) determinations could be a useful approach for improving the management of patients with intra-abdominal sepsis

    Temporal trends of circulating nitric oxide and pro-inflammatory cytokine responses ex vivo in intra-abdominal sepsis: results from a cohort study.

    No full text
    OBJECTIVE AND DESIGN: To evaluate the association of pro-inflammatory mediators with organ dysfunction and adverse outcome in intra-abdominal sepsis patients. SUBJECTS: Twenty-one patients admitted to the Intensive Care Unit (ICU) were prospectively included in the study. Only patients with surgical diagnosis of intra-abdominal sepsis were enrolled. RESULTS: Tumor necrosis factor-alpha (TNFalpha) and interleukin (IL)-6 produced ex vivo were significantly lower in non-survivors on admission (p = 0.021) and day 2 (p = 0.013), respectively. Nitric oxide (NO( x )) levels were significantly higher in non-survivors from the onset of sepsis and until day 4 after diagnosis (p < 0.05). Circulating lymphocyte counts were lower in non-survivors after admission over time, but there was no association with impaired cytokine production in this group of patients during the entire follow-up. All non-survivors developed nosocomial pneumonia concomitantly with multiple organ dysfunction and septic shock. There was a significant correlation between nitric oxide (NO( x )) concentrations and the sequential organ failure assessment (SOFA) score at day 2 (r = 0.598, p = 0.009), and ICU stay (r = 0.605, p = 0.006). Continuously high NO( x ) levels correlated with organ failure. The pro-inflammatory mediators TNFalpha, IL-6 and NO( x ), and also the Simplified Acute Physiology Score II (SAPS-II), discriminate survivors from non-survivors. According to logistic regression models, although these parameters are independently associated with the outcome, they do not improve the predictive power of the SAPS-II score for mortality risk. CONCLUSIONS: Disturbances in inflammatory responses and increase in NO( x ) generation seem to characterize early intra-abdominal sepsis, in which immune suppression is associated with an increased susceptibility to nosocomial infections. Sequential NO( x ) determinations could be a useful approach for improving the management of patients with intra-abdominal sepsis
    corecore