Anti-inflammatory and antiproliferative activities of date palm pollen (Phoenix dactylifera) on experimentally-induced atypical prostatic hyperplasia in rats

<p>Abstract</p> <p>Background</p> <p>Atypical prostatic hyperplasia (APH) is a pseudoneoplastic lesion that can mimic prostate adenocarcinoma because of its cytologic and architectural features. Suspension of date palm pollen (DPP) is an herbal mixture that is widely used in folk medicine for male infertility. The aim of the present study was to evaluate the effect of DPP suspension and extract on APH-induced rats.</p> <p>Methods</p> <p>APH was induced in adult castrated Wistar rats by both s.c. injection of testosterone (0.5 mg/rat/day) and smearing citral on shaved skin once every 3 days for 30 days. Saw palmetto (100mg/kg), DPP suspension (250, 500 and 1000 mg/kg), and lyophilized DPP extract (150,300 and 600 mg/kg) were given orally daily for 30 days. All medications were started 7 days after castration and along with testosterone and citral.</p> <p>Results</p> <p>The histopathological feature in APH-induced prostate rats showed evidence of hyperplasia and inflammation. Immunohistochemical examination revealed that the expressions of IL-6, IL-8, TNF-α, IGF-1 and clusterin were increased, while the expression of TGF-β1 was decreased that correlates with presence of inflammation. Moreover, histopathological examination revealed increased cellular proliferation and reduced apoptosis in ventral prostate. Both saw palmetto and DPP treatment has ameliorated these histopathological and immunohistochemical changes in APH-induced rats. These improvements were not associated with reduction in the prostatic weight that may be attributed to the persistence of edema.</p> <p>Conclusion</p> <p>DPP may have a potential protective effect in APH-induced Wistar rats through modulation of cytokine expression and/or upregulation of their autocrine/paracrine receptors.</p

Non-Diethylstilbestrol-Associated Primary Clear Cell Carcinoma of the Vagina: Two Case Reports with Immunohistochemical Studies and Literature Review

Primary clear cell adenocarcinomas most commonly involve the genitourinary system, including the vagina. Previously, primary clear cell adenocarcinomas of the vagina have been discussed within the context of prenatal exposure to diethylstilbestrol. Due to its widely proven role in the development of this carcinoma, administration of diethylstilbestrol is prohibited. We present two cases of non-diethylstilbestrol-associated primary clear cell adenocarcinoma of the vagina from the archives of the Anatomical Pathology Department at King Abdulaziz University in order to improve our understanding of its biological behavior. Our findings suggest that primary clear cell adenocarcinoma of the vagina may be unrelated to diethylstilbestrol exposure and that non-diethylstilbestrol-associated primary clear cell adenocarcinoma of the vagina, when present at a younger age, may have a worse prognosis

Bacterial and Mycotic Infections in immunocompromised hosts: Clinical and Microbiological Aspects

Causative organisms (Fungi) 2. Pathological Basis and Morphological Features 3. Gynecological Infections in Immunocompromised Hosts 4. Sexually Transmitted Diseases 5. Central Nervous System Infections in Immunocompromised Hosts 6. Skin and Soft Tissues Infections - 7. Sepsis in an Immunocompromised Host 8. Microsporidia Infections in Immunocompromised Hosts 9. Yeasts: Candida and Cryptococcus 10. Dimorph and Filamentous Fungi 11. Brucellosis: A Global Re-emerging Zoonosis: History, Epidemiology, Microbiology, Immunology and Genetic 12. Brucellosis: A Global Re-emerging Zoonosis: Clinical Aspects, Associations and Brucellosis in Specific Conditions 13. Brucellosis: A Global Re-emerging Zoonosis: Diagnosis, Treatment and PreventionThis book deals with bacterial and mycotic infections considering the particular aspects involved in the immunocompromised host. It is addressed to all people (microbiologists or pathologists) who for their activity have to face every day the clinical and microbiological features of these diseases. The immunocompromised hosts are a real problem for the peculiar characteristic that these subjects show and for the problems arisen in their treatment. We tried to examine most of infectious diseases such as the gynecological infections, the sexually transmitted diseases , the sepsis , the CNS infections and so on, stressing the diagnosis , the management and the prevention of the diseases and considering the newest aspects i.e. the formation of the bacterial biofilm in the devices or prostheses and the consequent resistance to the antimicrobial agents