Radiation dose management in thoracic CT: an international survey

PURPOSEWe aimed to examine current practice patterns of international thoracic radiologists regarding radiation dose management in adult thoracic computed tomography (CT) examinations. MATERIALS AND METHODSAn electronic questionnaire was sent to 800 members of five thoracic radiology societies in North America, Europe, Asia, and Latin America addressing radiation dose training and education, standard kVp and mAs settings for thoracic CT, dose reduction practices, clinical scenarios, and demographics. RESULTSOf the 800 radiologists, 146 responded to our survey. Nearly half (66/146, 45% [95% confidence interval, 37%–53%]) had no formal training in dose reduction, with “self-study of the literature” being the most common form of training (54/146, 37% [29%–45%]). One hundred and seventeen (80% [74%–87%]) had automatic exposure control, and 76 (65% [56%–74%]) used it in all patients. Notably, most respondents (89% [84%–94%]) used a 120 to 125 kVp standard setting, whereas none used 140 kVp. The most common average dose-length-product (DLP) value was 150 to 249 mGy.cm (75/146, 51% [43%–59%]), and 59% (51%–67%) delivered less than 250 mGy.cm in a 70 kg patient. There was a tendency towards higher DLP values with multidetector-row CT. Age, gender, and pregnancy were associated more with dose reduction than weight and clinical indication. CONCLUSIONEfforts for reducing patient radiation dose are highly prevalent among thoracic radiologists. Areas for improvement include reduction of default tube current settings, reduction of anatomical scan coverage, greater use of automatic exposure control, and eventually, reduction of current reference dose values. Our study emphasizes the need for international guidelines to foster greater conformity in dose reduction by thoracic radiologists

Comparison of axial, coronal, and primary 3D review in MDCT colonography for the detection of small polyps: a phantom study

The purpose of this phantom study is to compare the influence of the reading technique (axial images alone in comparison to 3D endoluminal, coronal, and combined 2D/3D review methods) on the sensitivity and inter-reader variability with MDCT colonography for the detection of small colonic polyps. An anthropomorphic pig colon phantom with 75 randomly distributed simulated small polyps of 2-8mm size, was distended with air and scanned in a water phantom using multidetector-row CT with 4mm x 1mm collimation. Three radiologists rated the presence of polyps on a five-point scale. Performance with axial sections alone was compared to the performance with coronal sections, virtual endoscopy (VE), and a combined 2D/3D approach. We calculated sensitivities for polyp detection and used ROC analysis for data evaluation. There was no significant difference between the mean area under the curve (A(z)) for axial images and VE (A(z)=0.934 versus 0.932), whereas coronal images were significantly inferior (A(z)=0.876) to both. The combined 2D/3D approach yielded the best results, with an A(z) of 0.99. Differences in sensitivity between individual readers were significant in axial images (sensitivity, 75-93%, p=0.001) and coronal images (sensitivity, 69-80%, p=0.028), but became non-significant with VE (83-88%, p=0.144) and the combined 2D/3D approach (95-97%, p=0.288). Evaluation of axial sections alone leads to significant differences in detection rates between individual observers. A combined 2D/3D evaluation improves sensitivities for polyp detection and reduces inter-individual differences to an insignificant leve

Quantitative CT in the follow up of functionally stable lung transplant recipients

Objectives: To quantify lung parenchymal changes in functionally stable lung transplant recipients using combined inspiratory and expiratory CT. Methods/Materials: Twenty patients after double lung trans- plantation, all of which were stable with regards to clinical pre- sentation and lung function (i.e., no evidence of graft rejection), underwent yearly combined inspiratory and expiratory CT examinations over 5 years. Lung parenchymal densitometric and quantitative airway metrics were calculated with dedicated soft- ware. The longitudinal evolution of the metrics was compared within individual patients, and relative changes were compared between individuals. Comparisons were performed using analyses of variance for repeated measurements, and linear regression analyses were used for data modeling. Results: Over the 5-year study period, CT measured lung weight and histogram peaks showed statistically significant decreases (p = 0.012 and p 0.05). Conclusions: On quantitative CT, functionally stable lung trans- plant recipients show a consistent pattern of longitudinal tissue loss, combined to increasing gas trapping. None of these changes are detected by the lung function test currently used as reference standard for following these patients

Worldwide trends in population-based survival for children, adolescents, and young adults diagnosed with leukaemia, by subtype, during 2000–14 (CONCORD-3): analysis of individual data from 258 cancer registries in 61 countries

Background: Leukaemias comprise a heterogenous group of haematological malignancies. In CONCORD-3, we analysed data for children (aged 0–14 years) and adults (aged 15–99 years) diagnosed with a haematological malignancy during 2000–14 in 61 countries. Here, we aimed to examine worldwide trends in survival from leukaemia, by age and morphology, in young patients (aged 0–24 years). Methods: We analysed data from 258 population-based cancer registries in 61 countries participating in CONCORD-3 that submitted data on patients diagnosed with leukaemia. We grouped patients by age as children (0–14 years), adolescents (15–19 years), and young adults (20–24 years). We categorised leukaemia subtypes according to the International Classification of Childhood Cancer (ICCC-3), updated with International Classification of Diseases for Oncology, third edition (ICD-O-3) codes. We estimated 5-year net survival by age and morphology, with 95% CIs, using the non-parametric Pohar-Perme estimator. To control for background mortality, we used life tables by country or region, single year of age, single calendar year and sex, and, where possible, by race or ethnicity. All-age survival estimates were standardised to the marginal distribution of young people with leukaemia included in the analysis. Findings: 164 563 young people were included in this analysis: 121 328 (73·7%) children, 22 963 (14·0%) adolescents, and 20 272 (12·3%) young adults. In 2010–14, the most common subtypes were lymphoid leukaemia (28 205 [68·2%] patients) and acute myeloid leukaemia (7863 [19·0%] patients). Age-standardised 5-year net survival in children, adolescents, and young adults for all leukaemias combined during 2010–14 varied widely, ranging from 46% in Mexico to more than 85% in Canada, Cyprus, Belgium, Denmark, Finland, and Australia. Individuals with lymphoid leukaemia had better age-standardised survival (from 43% in Ecuador to ≥80% in parts of Europe, North America, Oceania, and Asia) than those with acute myeloid leukaemia (from 32% in Peru to ≥70% in most high-income countries in Europe, North America, and Oceania). Throughout 2000–14, survival from all leukaemias combined remained consistently higher for children than adolescents and young adults, and minimal improvement was seen for adolescents and young adults in most countries. Interpretation: This study offers the first worldwide picture of population-based survival from leukaemia in children, adolescents, and young adults. Adolescents and young adults diagnosed with leukaemia continue to have lower survival than children. Trends in survival from leukaemia for adolescents and young adults are important indicators of the quality of cancer management in this age group