Strategies to improve the comprehension of struggling readers and the elementary level

Comprehension occurs when a reader constructs meaning from the text. Each reader must use a strategy to best suit their interaction with the text. By internalizing reading strategies, students will become successful readers. Education is part of a research based instructional practice movement. This paper describes five instructional methods used to teach comprehension strategies to elementary students and the research that supports them. The paper closes with conclusions and recommendations for teaching comprehension strategies

Dietary and Intraperitoneal Administration of Selenium Provide Comparable Protection in the 6-Hydroxydopamine Lesion Rat Model of Parkinson's Disease

Significant research implicates the involvement of free radicals in the manifestation of Parkinson's disease. The antioxidant, selenium is a vital dietary component for mammals. It is present in the active center of glutathione peroxidase, an antioxidant enzyme that scavenges peroxides and protects membrane lipids and macromolecules from oxidative insult. The purpose of this research was to determine an effective means of delivering selenium as well as an appropriate time frame for antioxidant administration that would elicit a protective response in rats challenged with an intranigral 6-hydroxydopamine (6-OHDA) lesion. In the first part of this study, Fischer 344 rats were placed into one of four groups: selenium enhanced diet, control diet, intraperitoneal injection of selenium as Na2SeO3 or intraperitoneal injection of distilled water. All treatments were delivered prior to an intranigral 6-OHDA lesion. Animals were euthanized two weeks post lesion and their brains processed for tyrosine hydroxylase (TH) immunocytochemistry. Average dopamine neuron survival in the substantia nigra of control animals was less than 22%; whereas nigral dopamine neuron survival in the selenium fed group was 49.7% and 56.0% in the selenium injected group. Based on these results, a subsequent study was designed utilizing the selenium enhanced diet method of antioxidant administration. To examine the neuroprotective effect of long-term selenium treatment, pregnant Fischer 344 rats were exposed to either selenium enhanced or control rat chow. Their pups were treated with the same diet as their mothers and lesioned with 6-OHDA at two months of age. Animals were euthanized and their brains were processed for TH immunocytochemistry. Nigral dopamine neuron survival for the selenium treated animals was significantly protective (59%) when compared to the control chow fed animals (29.6%). However, when compared to the short-term exposure of selenium rat chow in the previous study, there was no significant increase in neuroprotection

Building belonging in online WIL environments – lessons (re)learnt in the pandemic age: a collaborative enquiry

The theme of belonging in e-pedagogy gained currency in the 2000s when educational providers hastened to join the online teaching and learning boom and studies of building and maintaining a sense of community (SOC) proved central to this endeavour. Motivated by the pandemic-era necessity to convene teaching and learning online as part of a response to super-complexity as a defining feature of tertiary education in the 21st century, work-integrated learning (WIL) practitioners returned to this scholarship to consider, under pressure, modes of building SOC and belonging in online spaces. Underpinned by a broadly constructivist worldview and informed by the Community of Inquiry (CoI) framework, our COVID-age study considers what pedagogical strategies are viewed as affording learners this sense of belonging - or not. Using a collaborative enquiry to pool our perceptions and experiences from three WIL contexts, we ask how work-integrated learning (WIL) practitioners build belonging in online spaces and identify strategies learners perceive as valuable. Drawing on the authors’ small-scale studies of educator and learner experiences of online WIL (eWIL), our collaborative enquiry uses qualitative descriptive analysis to identify key themes in the voices of students. Advancing the scholarship, our study identifies three threads to the fabric of belonging: humanising online WIL; the importance of mentor presence; and fostering professional belonging. The study suggests that strategies impacting these three areas are at the heart of building belonging in online spaces, broadly envisaged as imagined professional communities of practice. Techniques viewed as successful are advanced as possibilities for enhancing pedagogy in online WIL communities

Taphonomy and Zooarchaeology of Faunal Assemblages from Archaeological Sites along the Upper Susitna River, Alaska

Reported here is a zooarchaeological and taphonomic analysis of faunal material from the archaeological sites HEA-455 and HEA-499, located in the upper Susitna River basin in the central Alaska Range. The bones are highly fragmented, yet indications of human activities and behaviors related to subsistence and site maintenance can still be inferred. The goal of the study was to determine what kind of information can be gleaned from highly fragmentary burned faunal assemblages typical of prehistoric sites in Alaska. The faunal assemblages used in this study were zooarchaeologically and taphonomically analyzed by identifying any preserved skeletal elements using reference collections, sorted based on fragment sizes and degree of burning evident on the bone fragments, and by assessing the relationship between bone fragment size and degree of burning intensity within and between sites. The bone fragments from these two archaeological sites appear to be burned directly from human activities. Results provide insight into prehistoric subsistence and site activities related to intensive burning of hunted faunal remains in the mountainous Alaska Range during the middle Holocene, as well as a better understanding of taphonomic processes in play in northern, subarctic environments

Alternative Hosts for Soybean vein necrosis virus and Feeding Preferences of Its Vector Soybean Thrips

Soybean vein necrosis virus (SVNV), a tospovirus and one of the most widespread soybean viruses in North America, is primarily transmitted by soybean thrips (Neohydatothrips variabilis). Although soybean is not considered the primary plant host for SVNV, there is a dearth of knowledge about alternative host plants for SVNV. We therefore investigated whether commonly present specialty and cover crops in Iowa can serve as alternative hosts for SVNV. Seventeen cover crops and seven specialty crops were tested using mechanical and thrips inoculations. Clear symptoms of SVNV and systemic infection in buckwheat and clear local infection with possible systemic infection on melon were shown. Additionally, we compared soybean thrips feeding on 18 cover crops and determined that they preferred alfalfa, buckwheat, crimson clover, and red clover. Our results suggested that alternative host crops may harbor SVNV and be a possible source of inoculum for soybean

Ethnicity and survival after a dementia diagnosis: a retrospective cohort study using electronic health record data

BackgroundIndividuals from minority ethnic groups in the UK are thought to be at higher risk of developing dementia while facing additional barriers to receiving timely care. However, few studies in the UK have examined if there are ethnic disparities in survival once individuals receive a dementia diagnosis.MethodsWe conducted a retrospective cohort study using electronic health record data of individuals diagnosed with dementia from a large secondary mental healthcare provider in London. Patients from Black African, Black Caribbean, South Asian, White British, and White Irish ethnic backgrounds were followed up for a 10-year period between 01 January 2008 and 31 December 2017. Data were linked to death certificate data from the Office of National Statistics to determine survival from dementia diagnosis. Standardised mortality ratios were calculated to estimate excess deaths in each ethnicity group as compared to the gender- and age-standardised population of England and Wales. We used Cox regression models to compare survival after dementia diagnosis across each ethnicity group.ResultsMortality was elevated at least twofold across all ethnicity groups with dementia compared to the general population in England and Wales. Risk of death was lower in Black Caribbean, Black African, White Irish, and South Asian groups as compared to the White British population, even after adjusting for age, gender, neighbourhood-level deprivation, indicators of mental and physical comorbidities. Risk of death remained lower after additionally accounting for those who emigrated out of the cohort.ConclusionsWhile mortality in dementia is elevated across all ethnic groups as compared to the general population, reasons for longer survival in minority ethnic groups in the UK as compared to the White British group are unclear and merit further exploration. Implications of longer survival, including carer burden and costs, should be considered in policy and planning to ensure adequate support for families and carers of individuals with dementia.Introductio

Evaluation and quantification of associations between commonly suggested milk biomarkers and the proportion of grassland-based feeds in the diets of dairy cows

This study is a first step approach towards the prediction of the proportion of grassland-based feeds (%GB) in dairy cow diets with the aid of three different groups of milk biomarkers. We aimed to evaluate and quantify the associations between biomarkers commonly suggested in the literature and %GB in individual cows as a hypothesis-generating stage for the prospective establishment of accurate %GB prediction models. Consumers and governments financially encourage sustainable, local milk production making grass-based feeding, in grassland-dominated regions, of major interest. Milk from grassland-fed cows differs from that of other feeding systems by inferential fatty acids (FA), β-carotene content and yellow color; however, these biomarkers have not been evaluated together for their association with %GB. Using approved methods of parametric regression analysis, gas chromatography (GC), mid-infrared spectra (MIR) and color spectroscopy, we aimed to develop a first step towards an easy-to-implement, cost-effective milk-based control to estimate %GB in dairy cow diets. The underlying database was generated with 24 cows each fed one of 24 different diets gradually increasing in grass silage and decreasing in corn silage. Our results indicate that GC-measured α-linolenic acid, total n-3 FA and the n-6:n-3 ratio, MIR-estimated PUFA and milk red-green color index a* are robust milk biomarkers for constructing accurate prediction models to determine %GB. Based on simplified regression analysis, diets containing 75% GB should contain ≥ 0.669 and 0.852 g α-linolenic acid and total n-3 FA per 100 g total FA, respectively, and an n-6:n-3 FA ratio of < 2.02 measured with GC; estimated with MIR, polyunsaturated FA should be ≥ 3.13 g/100 g total FA. β-carotene was not a good predictor for estimating %GB. Unexpectedly, the milk became greener with increasing %GB (negative a* values, ‒6.416 for 75% GB), suggesting the red-green color index, not yellow-blue, as a suitable biomarker

Eftilagimod alpha, a soluble lymphocyte activation gene-3 (LAG-3) protein plus pembrolizumab in patients with metastatic melanoma

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. BACKGROUND: To evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of eftilagimod alpha (efti), a soluble lymphocyte activation gene-3 protein, in combination with the programmed cell death-1 (PD-1) antagonist pembrolizumab. METHODS: The study was divided into two parts; parts A and B, where part A was the dose escalation part and part B was an extension part of the study. Patients with metastatic melanoma were treated with efti plus the standard dose of pembrolizumab. Blood samples were assayed to determine plasma pharmacokinetic parameters, detect efti antibody formation and determine long-lived CD8 T cell responses and associated pharmacodynamic parameters. RESULTS: Twenty-four patients with melanoma received pembrolizumab and bi-weekly subcutaneous (s.c.) injections of efti at doses 1 mg, 6 mg or 30 mg/injection for up to 6 months (part A) or 30 mg/injection for up 12 months (part B). No dose-limiting toxicities were reported and the main adverse event for efti was injection site reactions. Sustained systemic exposure to the product was obtained in all patients following s.c. injections of 30 mg dose. Treatment induced an increase in activated CD8 and CD4 T cell counts, and in some of the soluble biomarkers, particularly interferon (IFN)-γ, a Th1 signature cytokine. An overall response rate (ORR) of 33% was observed in patients partly with pembrolizumab-refractory of part A and ORR of 50% was observed in patients with PD-1 naïve of part B. CONCLUSIONS: Efti was well tolerated in combination with pembrolizumab with encouraging antitumor activity. This warrants further clinical studies of this new combination therapy combining an antigen-presenting cell activator with an immune checkpoint inhibitor