Subjugation of Women in Githa Hariharan’s When Dreams Travel

The focus of this paper is to depict the subjugation of women in Githa Hariharan’s prestigious novel, When Dreams Travel. This novel of Githa Hariharan investigates the possibility of women’s presence, survival and personality emergency alongside different dimensions. At the point When Dreams Travel depicts the subjugation and oppression of women in patriarchal society. Apparently, Hariharan's direction is absolutely remarkable and described in an ornate way. Githa Hariharan's When Dreams Travel is revised aspect of Middle Eastern myth “A Thousand and One Nights”. By re-revealing to Shahrzad's story from a feministic viewpoint, Hariharan forces upon the reader an entire re-evaluating of the revulsion of women so clear in the celebrated interpretations of medieval anthologies

Specificity and Personalized medicine: a novel approach to Cancer management

With the advent of precision and personalized medicine (PPM), medical care may now be adapted to each patient's unique needs. Among the top causes of death in India is cancer. Maximum chemotherapeutic treatments are utilized for cancer patients, despite the lack of long-term effectiveness and significant side effects from these agents. To improve therapeutic success, a new tool called PPM was developed. Insights into pharmacogenomics have aided in the development of and the possibility for individualized cancer treatment. In modern PPM, genetic or other information on a particular patient is used systematically to select or optimize preventative and therapeutic therapy for that patient. Knowledge of a patient's protein, genetic, and metabolic profile can help doctors give them the best possible care. The development of companion diagnostics, in which molecular assays measuring levels of proteins, genes, or specific mutations are used to stratify disease status, pick the appropriate drug, and tune dosages there, is a central feature of this medical strategy. As a result, recent breakthroughs in oncology have piqued interest in the field as a whole, prompting calls for greater emphasis on the role of the oncology department or health care system in the quest for greater accuracy and individualization. In this article, we will examine the state of the art and discuss potential future developments that could help expedite the creation of PPM medicines for the treatment of cancer that has become resistant to standard therapies in individual patients. The focus will be on the phenotypic (activity-based) rather than the genotypic (mechanism-based) approach to PPM development, and how it can benefit cancer patients. The path to precise and individualized treatment has been opened by the article's perspective, in which focus is placed on the specific modifications of the tumor

Reproductive Health of Women: Implications and attributes

Complete access to sexual and reproductive health is a fundamental human right. Women and girls all across the world, particularly those living in poverty, have little or no access to reproductive health and rights information and services. Discrimination, shame, restrictive laws and regulations, and long-held traditions are just a few of the barriers to sexual and reproductive health that exist. Despite evidence that these rights may affect not only individual women but also families, communities, and national economies, progress has been slow. Women\u27s lifestyles have evolved throughout history. In the past, most women\u27s lives were challenging. Many ladies were having unintended pregnancies. Childbirth used to be dangerous, and it often resulted in the mother\u27s death. Because they didn\u27t live long enough, most women didn\u27t have to deal with menopause or old age in the past. Reproductive health is an important aspect of a person\u27s entire development and well-being. It could be the result of a positive upbringing, which is critical during adolescence and sets the tone for excellent health throughout adulthood and beyond reproductive years for both men and women. A woman\u27s reproductive life span does not begin at puberty and end at menopause, and a man\u27s reproductive life span does not stop when he is no longer likely to bear children. It is present and vital at all stages of a person\u27s development and maturation. Reproductive health needs may vary depending on one\u27s age and stage of life. However, there is a long term effect over the course of one\u27s life, and each stage has significant ramifications for one\u27s future well-being

Neuroprotective Activity of Herbal Medicinal Products: A Review

Plant-based drugs are among the earliest pharmaceuticals documented in even the most basic medical system's history. They are the most often used medicines due to their wide acceptance and general perception of their safer profile as compared to conventional drugs. Herbal medicines and products are gaining popularity around the world, not just as a caffeine-free alternative, but also as dietary supplements for low-calorie diets. In recent years, traditional medicine has gotten increased attention. Traditional medicine uses a range of herbs to cure neurodegenerative disorders such as Alzheimer's and other similar central nervous system issues. The term "neuroprotection" refers to strategies and systems for preventing neuronal injury in the central nervous system (CNS). Humans still have access to nature's medicines. Many important drugs are obtained from natural sources or based on the structural characteristics of naturally occurring substances, such as vincristine, artemisinin, and gentamicin. Traditional medicine has been documented to use a number of natural substances, usually plant extracts, for neuroprotective, memory-enhancing, and anti-aging objectives. Such plants include Panax ginseng, Ginkgo biloba, Bacopa monnieri, Curcuma longa, and Salvia officinalis. These plants were studied to see if the traditional claim was true, as well as to learn more about the mechanism through which they give neuroprotective advantages

Menstruation hygiene and related issues in adolescent girls: A brief commentary

Between childhood and adulthood, adolescence is a phase of physiological, psychological, and social transformation. Menstrual difficulties are a common symptom and one of the primary causes of adolescent doctor visits. Therefore, adolescent girls' knowledge of reproductive health, including menstruation, may be incomplete and impacted by sociocultural obstacles. The majority of teenage females in India know nothing about menstruation, reproduction, and sexuality. As menstruation remains a taboo, the culture adheres to numerous myths and prohibitions. During menstruation, poor personal cleanliness and dangerous sanitary circumstances heighten the risk of reproductive tract infections and gynecological issues. In resource-poor environments, where women lack access to basic facilities such as water, bathrooms, and privacy, it is extremely difficult to maintain a high level of hygiene. There is a need to enhance housing conditions in terms of fundamental amenities. Every girl may only be encouraged to use sanitary pads if they are offered at cheap costs. It is urgent that separate teenage gynecological clinics be established. Sensitization and counseling in schools, together with a complete school education program on menarche and menstruation difficulties, may assist girls in coping better and seeking appropriate medical support. Keywords: Menstrual disorders, Adolescence, Sanitary Pads, Reproductive Health

Insulin Resistance and Polycystic ovary Syndrome: A Review

Polycystic Ovary Syndrome (PCOS) is the most common, yet complex, endocrine disorder affecting women in their reproductive years and is a leading cause of infertility. This disease appears to be multifactorial and polygenic in nature involving multisystem dysfunction, namely reproduction, endocrine and metabolic. Hyperandrogenism and insulin resistance appear to be central cause to the pathophysiology of the disease. The glucose and insulin metabolism pathways have been studied and debated to understand whether Insulin Resistance is due to a defect in insulin action or a primary defect in β-cell function or decreased hepatic clearance of insulin, or a combination of all these factors. Numerous studies have demonstrated that obese, normal weight and thin women with PCOS have a form of insulin resistance that is unique and intrinsic to the disorder. Moreover obese women with PCOS possess an additional burden of insulin resistance resulting from their excess adiposity. Hyperinsulinemia leads to increase in androgen production directly by acting as a co-gonadotropin, augmenting Luteinizing Hormone activity within the ovary, and indirectly by increasing serum LH pulse amplitude. Whereas Androgens may in turn contribute at least partially to the insulin resistance state linked with PCOS.  In this review, we will briefly study the role of insulin resistance in polycystic ovary syndrome. Keywords: Polycystic ovary syndrome, insulin resistance, Hyperandrogenism

Animal Models in Diabetes Mellitus: An Overview

Diabetes mellitus is defined as a state in which homeostasis of carbohydrate and lipid metabolism is improperly regulated by insulin. This results primarily in elevated fasting and postprandial blood glucose levels. If this imbalanced homeostasis dose not returns to normalcy and continues for a protracted period of time, it leads to hyperglycemia, which in due course turns into a syndrome called diabetes mellitus. Several animal models have been developed for studying diabetes mellitus or testing anti-diabetic agents. These models include chemical, surgical (pancreatectomy) and genetic manipulations in several animal species to induce diabetes mellitus. The diabetogenic drugs used include: Alloxan monohydrate, Streptozotocin with or without nicotinamide, Ferric nitrilotriacetate, Ditizona and Anti-insulin serum. The selection of these models to use for investigating the antidiabetic properties of a new compound may be a very difficult task especially for young researchers. The aim of the present review is give a brief idea about various experimental models developed for studying diabetes mellitus, assess the merits and demerits of each model and highlight the precautions needed to avoid erroneous results during the applications of these models. Keywords: Diabetes Mellitus, Animal models, Alloxan, Streptozotocin

Surgery for complicated pulmonary tuberculosis

Abstract not availabl

Surgery for complicated pulmonary tuberculosis

Abstract not availabl

Early results after transatrial repair of RVOT obstruction including teratology of fallot

Background: Right ventricular (RV) dysfunction is a significant cause of morbidity and mortality after surgical correction of RVOT obstruction including tetralogy of Fallot (TOF). Transatrial repair avoids a ventriculotomy (in contrast to the transventricular approach) emphasizing maximal preservation of RV structure and function. We have adopted this technique as less traumatic for the right ventricle. This study evaluates the early surgical results of our approach.Methods: Between January 2005 to January 2014, 77 consecutive patients with RVOT obstruction were referred to our unit for surgical therapy. Of these, 14 were unsuitable for repair and underwent aortopulmonary shunting. In the remaining 63 patients (mean age of 2.67±0.38 years), complete transatrial/transpulmonary repair was performed. Previously placed shunts (four patients) were taken down. In all cases, subpulmonary resection and ventricular septal defect (VSD) closure were accomplished transatrially. In 51 patients, the main pulmonary artery was augmented with an autologous pericardial patch.Results: There were 7 (9%) deaths in this series. No patient required permanent pacemaker. Median ICU and hospital stay were 91 hours and 14 days, respectively. At median follow up of 54 (mean 51±12) months, all patients are asymptomatic, with no significant residual lesion.Conclusions: Transatrial/transpulmonary repair of TOF is associated with remarkably low morbidity and mortality in our early experience