Trabajo remoto en el área de planificación y presupuesto en una UGEL de Lima Norte, 2022

El objetivo general de la tesis fue conocer la importancia del trabajo remoto en el área de planificación y presupuesto de una UGEL de Lima Norte, 2022. El estudió utilizado es un diseño de investigación no experimental, con un enfoque cualitativo. Los resultados del desarrollo de la tesis, reflejan las ventajas existentes del trabajo remoto, en el desempeño en las funciones asignadas a los colaboradores del área de planificación y presupuesto de una UGEL de Lima Norte, tales como la disminución de los gastos de transporte y el poder contar con un mayor tiempo para estar con sus familias. Por último, se llegó a la conclusión que, el trabajo remoto es importante en el desarrollo de las funciones asignadas a los colaboradores del Área de Planificación y Presupuesto, a razón de permitirles realizar las mismas funciones desde sus hogares, beneficiando a los colaboradores

Buenas prácticas para la optimización del centro de datos de Intralot de Perú basado en el estándar ANSI/TIA-942

Publicación a texto completo no autorizada por el autorSe narra el proceso de elaboración del informe de diagnóstico y recomendaciones para el centro de datos de Intralot de Perú. El objetivo de estas recomendaciones es que el centro de datos de dicha empresa adopte el nivel 1 (TIER 1) del estándar ANSI/TIA-942, con el objetivo de mitigar el riesgo, maximizar la disponibilidad y garantizar la integridad de los sistemas de la empresa. Para cumplir con este objetivo se realizó el análisis de cuatro aspectos que se definen en el estándar: telecomunicaciones, arquitectura y estructura, eléctrico y sistemas mecánicos. Para cada uno de estos aspectos se define un conjunto de controles que Intralot de Perú debe cumplir para poder declararse compatible con el nivel 1 buscado. Como resultado de este análisis se encontró que Intralot de Perú pasa la mayoría de los controles, mientras que los puntos faltantes se convierten en las recomendaciones de la investigación. Finalmente se sugiere considerar formas alternativas de optimización tales como virtualización, hiperconvergencia o incluso computación en la nube.Trabajo de suficiencia profesiona

Actinobacteria from arctic and atlantic deep-sea sediments—biodiversity and bioactive potential

The deep-sea covers over 70% of the Earth’s surface and harbors predominantly uncharacterized bacterial communities. Actinobacteria are the major prokaryotic source of bioactive natural products that find their way into drug discovery programs, and the deep-sea is a promising source of biotechnologically relevant actinobacteria. Previous studies on actinobacteria in deep-sea sediments were either regionally restricted or did not combine a community characterization with the analysis of their bioactive potential. Here we characterized the actinobacterial communities of upper layers of deep-sea sediments from the Arctic and the Atlantic (Azores and Madeira) ocean basins, employing 16S rRNA metabarcoding, and studied the biosynthetic potential of cultivable actinobacteria retrieved from those samples. Metabarcoding analysis showed that the actinobacterial composition varied between the sampled regions, with higher abundance in the Arctic samples but higher diversity in the Atlantic ones. Twenty actinobacterial genera were detected using metabarcoding, as a culture-independent method, while culture-dependent methods only allowed the identification of nine genera. Isolation of actinobacteria resulted on the retrieval of 44 isolates, mainly associated with Brachybacterium, Microbacterium, and Brevibacterium genera. Some of these isolates were only identified on a specific sampled region. Chemical extracts of the actinobacterial isolates were subsequently screened for their antimicrobial, anticancer and anti-inflammatory activities. Extracts from two Streptomyces strains demonstrated activity against Candida albicans. Additionally, eight extracts (obtained from Brachybacterium, Brevibacterium, Microbacterium, Rhodococcus, and Streptomyces isolates) showed significant activity against at least one of the tested cancer cell lines (HepG2 and T-47D). Furthermore, 15 actinobacterial extracts showed anti-inflammatory potential in the RAW 264.4 cell model assay, with no concomitant cytotoxic response. Dereplication and molecular networking analysis of the bioactive actinobacterial extracts showed the presence of some metabolites associated with known natural products, but one of the analyzed clusters did not show any match with the natural products described as responsible for these bioactivities. Overall, we were able to recover taxonomically diverse actinobacteria with different bioactivities from the studied deep-sea samples. The conjugation of culture-dependent and -independent methods allows a better understanding of the actinobacterial diversity of deep-sea environments, which is important for the optimization of approaches to obtain novel chemically-rich isolates.info:eu-repo/semantics/publishedVersio

MarinEye - A tool for marine monitoring

This work presents an autonomous system for marine integrated physical-chemical and biological monitoring – the MarinEye system. It comprises a set of sensors providing diverse and relevant information for oceanic environment characterization and marine biology studies. It is constituted by a physicalchemical water properties sensor suite, a water filtration and sampling system for DNA collection, a plankton imaging system and biomass assessment acoustic system. The MarinEye system has onboard computational and logging capabilities allowing it either for autonomous operation or for integration in other marine observing systems (such as Observatories or robotic vehicles. It was designed in order to collect integrated multi-trophic monitoring data. The validation in operational environment on 3 marine observatories: RAIA, BerlengasWatch and Cascais on the coast of Portugal is also discussed.info:eu-repo/semantics/publishedVersio

Índice de progreso social del distrito de Lince

Los indicadores económicos, como el producto bruto interno (PBI), por sí solos, no miden el progreso social de la población. Es por ello que surgió el Índice de Progreso Social (IPS) como herramienta holística e integral que nos proporciona una medida de forma independiente a los indicadores económicos y el cual fue creado con la finalidad de apoyar las acciones de mejora del progreso social enfocada a satisfacer las necesidades básicas humanas, de establecer elementos fundamentales para la mejora del bienestar de las personas, y de crear las oportunidades para que los ciudadanos puedan lograr su desarrollo tanto personal como profesional. El IPS tiene tres dimensiones: Necesidades Humanas Básicas, Fundamentos del Bienestar y Oportunidades, donde cada una de ellas está conformada por cuatro componentes. Asimismo, la metodología del IPS abarca los principios de: a) indicadores exclusivamente sociales y ambientales, b) se enfoca en resultados y no en esfuerzos, c) es holístico y relevante para todos los países y d) es una herramienta aplicable que ayuda a los líderes de sociedad a implementar políticas para el progreso social. El propósito de la investigación es calcular el nivel de progreso social del distrito de Lince, departamento de Lima de acuerdo a la metodología implementada por la organización no gubernamental Social Progress Imperative y adaptada, a nivel distrital por CENTRUM Católica. El resultado de la presente investigación de enfoque cuantitativo y diseño no experimental ubica al distrito de Lince en un nivel medio bajo con un puntaje de 61.74 en una escala del 0 al 100, y a nivel de dimensiones obtuvo los siguientes resultados: en Necesidades Humanas Básicas obtuvo 70.24 puntos, en Fundamentos del Bienestar obtuvo 58.94 puntos y en Oportunidades obtuvo un puntaje de 56.03 puntos. La muestra estuvo conformada por 414 hogares y la recolección de datos se realizó a través de encuestas como fuente primaria, así como de fuentes secundarias provenientes de instituciones públicas. Esta medición permitirá a las autoridades del distrito conocer y comparar el progreso social del distrito de Lince y tomar las medidas necesarias a fin de supervisar y mejorar el progreso social, e implementar políticas públicas que ayuden al desarrollo social y medioambiental de sus habitantes. Asimismo, se pretende incentivar a la gestión municipal del distrito de Lince en continuar periódicamente con el cálculo de este indicador y así observar su evolución y el impacto logrado producto de las decisiones por parte de sus autoridades.Economic indicators, such as GDP, by themselves, do not measure the social progress of the citizens. The Social Progress Index (SPI) provides us an independent measure of economic indicators. That is why the Social Progress Index (SPI) emerged as a holistic and comprehensive tool that provides us with a measure independent of the economic indicators and which was created with the purpose of supporting actions to improve social progress of a society focused on satisfying the basic human needs, to establish fundamental elements for the improvement of people´s welfare, and to create opportunities for citizens to achieve their personal and professional development. The IPS has three dimensions: basic human needs, welfare fundamentals and opportunities, where each of them is made up of four components. Likewise, the IPS methodology covers the principles of a) exclusively social and environmental indicators, b) it focuses on results and not on efforts, c) it is holistic and relevant for all countries and d) it is an applicable tool that helps society leaders to implement policies for social progress. The purpose of the research is to calculate the level of social progress of the district of Lince, Lima, according to the methodology implemented by the nongovernmental organization Social Progress Imperative and adapted, at district level by CENTRUM Católica. The result of the present investigation of quantitative approach and non-experimental design locates the district of Lince in a middle-low level with a score of 61.74 on a scale from 0 to 100, and at the level of dimensions obtained the following results: in Basic Human Needs obtained 70.24 points, in Foundations of Wellbeing obtained 58.94 points and in Opportunities obtained a score of 56.03 points. The sample consisted of 414 homes and data collection was carried out through surveys as a primary source, as well as secondary sources from public institutions. This measurement will allow the district authorities to know and compare the social progress of the district of Lince and take the necessary measures to monitor and improve social progress and implement public policies that help the social and environmental development of its citizens. Likewise, it is intended to encourage the municipal management of the Lince district to periodically continue with the calculation of this indicator and thus observe its evolution and the impact achieved as a result of decisions by its authorities.Tesi

Vacuna hexavalente en el Perú. Hacia la cobertura segura y sostenida de la vacunación en la infancia. Consenso de expertos

Objetive. Immunization is one of the most important interventions to prevent morbidity and mortality in the world population. However, gaps persist to achieve ideal vaccination coverage. In addition, the multiple vaccines and necessary doses make it difficult to reach the minimum established goals. On this scenario, combined and fractionated vaccines are being developed with the aim of reducing the injections number, programmatic errors, reactogenicity and improving adherence.On three different days, for 9 hours, 6 pediatricians experts in vaccines in Peru met following the RAND/UCLA method in order to develop a consensus opinion and update of the combined hexavalent vaccine [DTaP+Haemophilus influenzae type b (Hib)+Hepatitis B (HVB)+Inactivated Polio Vaccine (IPV)] and its eventual use in the Extended Immunization Program (EPI). The consensus recommendation are: replace the vaccines, Oral Polio Vaccine (OPV) by IPV, pertussis of whole cells by acellular vaccines and DTP of 4 years old by dTap between 4 and 6 years old; use the hexavalent vaccine for the primary series (2, 4 and 6 months); use 4 doses of Hib vaccine (2, 4, 6 and 18 months); incorporate the hexavalent vaccine in the EPI; do not use fractionated IPV (fIPV) and only administer 4 doses of IPV.Objetivo. La inmunización es una de las intervenciones más importantes para prevenir la morbimortalidad en la población mundial. No obstante, aún persisten brechas para alcanzar coberturas ideales de vacunación. Además, las múltiples dosis y vacunas dificultan alcanzar las metas mínimas establecidas. Por ello, se desarrollan vacunas combinadas y fraccionadas para reducir el número de inyecciones, errores programáticos, reactogenicidad y mejorar la adherencia. En tres días distintos, durante 9 horas, se reunieron 6 médicos pediatras expertos en vacunas en el Perú siguiendo el método RAND/UCLA, con el objeto de elaborar un consenso de opinión y actualización de la vacuna combinada hexavalente [DTaP+Haemophilus influenzae tipo b (Hib)+Hepatitis B (HVB)+antipolio inactivada (IPV)] y su eventual uso en el Programa ampliado de inmunizaciones (PAI). Las recomendaciones del consenso son: reemplazar las vacunas, antipolio oral (OPV) por IPV, pertussis de células enteras por vacunas acelulares y DTP de los 4 años por dTap entre los 4 y 6 años; usar la vacuna hexavalente para la serie primaria (2, 4 y 6 meses); usar 4 dosis de vacuna contra Hib (2, 4, 6 y 18 meses); incorporar la vacuna hexavalente en el PAI; no usar la IPV fraccionada (fIPV) y administrar solo 4 dosis de IPV

Características epidemiológicas, clínicas, pre y posnatales de los neonatos, hijos de madre con la Covid-19, y del seguimiento hasta los 14 días post alta, en Lima-Perú

Objective: To describe prenatal and post-natal clinical features of neonates born from mothers with COVID-19 including 14-day follow-up post discharge. Methods: Case series of neonates attended at Hospital Guillermo Almenara born from mothers infected with COVID-19 during the lockdown implemented by the Peruvian government. Neonates were divided in two groups based on positivity of the nasopharyngeal PCR test. Results:201 pregnant women with COVID-19 diagnosed by rapid tests who delivered 206 neonates were identified; 4 of these neonates had positive nasopharyngeal PCR tests. Pregnants infected with COVID-19 were younger than non-infected, but no differences were observed in route of delivery, sex of the newborn and body weight at birth. Two hundred and five neonates were discharged one week after birth ;181 neonates with negative nasopharyngeal negative PCR tests and 4 neonates with a positive PCR test were followed for 14 days, none presented symptoms and received mixed lactation. Conclusions: Neonates born from mother infected with COVID-19 had minimal risk of getting the infection and their pre and post-natal development will not be affected despite of having a positive PCR test.Objetivo: Describir las características clínicas prenatales y post natales de los neonatos hijos de madres con la Covid-19, y seguimiento hasta los 14 días post alta. Material y métodos: Estudio tipo observacional, serie de casos, censal de los neonatos nacidos en el Hospital Guillermo Almenara Irigoyen, hijos de madres con la Covid-19, que nacieron durante la cuarentena decretada por el gobierno peruano. Los neonatos se dividieron en 2 grupos: con la prueba PCR nasofaríngea positiva o no y se observó si alguna de estas características estuvieron asociadas con la presentación de esta prueba positiva. Resultados: Hubieron 201 gestantes con diagnóstico de Covid-19 por prueba rápida y que tuvieron 206 neonatos. De ellos,  4 neonatos tuvieron la PCR nasofaríngea positiva y 202, negativa. La edad materna fue menor en el grupo con la prueba positiva, pero no hubo diferencia respecto al tipo de parto: césarea, fueron a termino, con adecuado peso al nacer y ningún sexo predominó. Doscientos cinco (99,51%) neonatos salieron de alta en la primera semana de vida; 181 (90,05%) neonatos con PCR nasofaríngea negativa y los4 neonatos con prueba positiva fueron seguidos por 2 semanas; ninguno presentó síntomas y el tipo de lactancia fue mixta. Conclusiones: Los neonatos hijos de madres con la Covid-19, tendrían una mínima posibilidad de contraer esta enfermedad. Y su desarrollo prenatal y post natal no se vería afectado, a pesar de incluso tener la prueba PCR nasofaríngea positiva

Proceso de definición de prioridades institucionales de investigación en el Seguro Social de Salud del Perú, 2020-2022

Introduction: Health research priorities definition address research efforts to the promotion of health science, technology, and innovation. Material and Methods: Health research priorities in the Peruvian Social Security for the period 2020-2022 was carried out in four stages using a systematic, structured, participatory and sequential process. Results: First, the progress of the research in the priorities of the period 2017-2019 was evaluated. In the second stage, various sources were consulted to identify disease-oriented research needs and the framework for priorities oriented to health systems and health interventions. The third stage consisted of an expanded consultation to select priority disease-oriented topics. Finally, a participatory and multidisciplinary workshop was developed to select themes, subtopics, and priority areas for research. Conclusion: The final product was the definition of 11 priority themes, seven for diseases and four for health systems and health interventions.Introducción: La definición de prioridades de investigación en salud dirige los esfuerzos de investigación para promover ciencia, tecnología e innovación en salud. Material y Métodos: La definición de estas en el Seguro Social de Salud peruano para el periodo 2020-2022 se realizó en cuatro etapas y de forma sistemática, estructurada, participativa y secuencial. Resultados: Primero, se evaluó el avance de investigación en las prioridades del periodo 2017-2019. En la segunda etapa, se consultó diversas fuentes y se identificó necesidades de investigación orientadas a enfermedades y se estableció el marco para prioridades orientadas a sistemas de salud e intervenciones sanitarias. La tercera etapa consistió en una consulta ampliada para seleccionar los temas prioritarios orientados a enfermedades. Finalmente, se desarrolló un taller participativo y multidisciplinario para seleccionar temas, subtemas y áreas prioritarias de investigación. Conclusión: El producto final fue la definición de 11 temas prioritarios, siete para enfermedades y cuatro para sistemas de salud e intervenciones sanitarias

Actinobacteria from Arctic and Atlantic deep-sea sediments—Biodiversity and bioactive potential

The deep-sea covers over 70% of the Earth’s surface and harbors predominantly uncharacterized bacterial communities. Actinobacteria are the major prokaryotic source of bioactive natural products that find their way into drug discovery programs, and the deep-sea is a promising source of biotechnologically relevant actinobacteria. Previous studies on actinobacteria in deep-sea sediments were either regionally restricted or did not combine a community characterization with the analysis of their bioactive potential. Here we characterized the actinobacterial communities of upper layers of deep-sea sediments from the Arctic and the Atlantic (Azores and Madeira) ocean basins, employing 16S rRNA metabarcoding, and studied the biosynthetic potential of cultivable actinobacteria retrieved from those samples. Metabarcoding analysis showed that the actinobacterial composition varied between the sampled regions, with higher abundance in the Arctic samples but higher diversity in the Atlantic ones. Twenty actinobacterial genera were detected using metabarcoding, as a culture-independent method, while culture-dependent methods only allowed the identification of nine genera. Isolation of actinobacteria resulted on the retrieval of 44 isolates, mainly associated with Brachybacterium, Microbacterium, and Brevibacterium genera. Some of these isolates were only identified on a specific sampled region. Chemical extracts of the actinobacterial isolates were subsequently screened for their antimicrobial, anticancer and anti-inflammatory activities. Extracts from two Streptomyces strains demonstrated activity against Candida albicans. Additionally, eight extracts (obtained from Brachybacterium, Brevibacterium, Microbacterium, Rhodococcus, and Streptomyces isolates) showed significant activity against at least one of the tested cancer cell lines (HepG2 and T-47D). Furthermore, 15 actinobacterial extracts showed anti-inflammatory potential in the RAW 264.4 cell model assay, with no concomitant cytotoxic response. Dereplication and molecular networking analysis of the bioactive actinobacterial extracts showed the presence of some metabolites associated with known natural products, but one of the analyzed clusters did not show any match with the natural products described as responsible for these bioactivities. Overall, we were able to recover taxonomically diverse actinobacteria with different bioactivities from the studied deep-sea samples. The conjugation of culture-dependent and -independent methods allows a better understanding of the actinobacterial diversity of deep-sea environments, which is important for the optimization of approaches to obtain novel chemically-rich isolates

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF

M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe