19 research outputs found
The glycocalix of the epithelial cells of the colon, observed in normal and ulcerous colitic conditions.
Biopsies of subjects affected by ulcerous colitis were stained with ruthenium Red. Alterations of the cellular coat and glycocalyx of the epithelial cells of the colon were identified
Quantification of Imatinib Plasma Levels in Patients with Chronic Myeloid Leukemia: Comparison Between HPLCUV and LCMS/MS
Measurement of imatinib plasma concentration
can be useful to evaluate patient adherence to daily oral
therapy, potential drug–drug interaction, treatment efficacy,
and severe drug-related adverse events. The aim of
this study was to correlate the two different blood level test
methods, HPLC–UV and LC–MS/MS. We analyzed 162
plasma samples from patients treated with imatinib. We
estimated the correlation between the two analytical
methods on total data set and on five sets of patients
grouped into different categories based on the drug-dose
therapy. Finally, imatinib quantification was correlated
with genetic data on the molecular response in monitoring
follow-up of CML patients