Effect of Mitomycin - C and Triamcinolone on Preventing Urethral Strictures

Urethral stricture is a common disease with high recurrence rate. Several manipulations were defined to prevent the recurrence but the results were disappointing. This study aimed to evaluate the efficacy of triamcinolone and mitomycin-C on urethral stricture formation and their effect on inhibition of urethral fibrosis. A total of 24 New Zealand rabbits were divided into 3 groups. Urethras of rabbits were traumatized with pediatric resectoscope. Resection area was irrigated with 10mL saline, swapped with a cotton wool soaked with 0.5mg/mL MMC and injected by 40mg triamcinolone in groups 1, 2 and 3 respectively. Retrograde urethrogram was performed at 28th day of procedure and the urethra was removed for histopathologic evaluation. There were significant differences in urethral diameters and in lumen reduction rate between the control and study groups (p< 0.001). Compared to control group, all treatment groups showed mild fibrosis, less collagen bundle irregularity, and lower numbers of fibroblasts (p= 0.003). The Tunnel assay showed that the number of apoptotic cells in the submucosal connective tissue was quantitatively higher in control groups (p= 0.034). In the view of efficacy and safety, MMC and triamcinolone have the potential to replace the use of stents, clean intermittent catheterization, or long term catheters following internal urethrotomy. There were no statistically significant differences between two agents in terms of preventing urethral stricture formation in the present study. Mitomycin C and triamcinolone decreased the recurrence rates of urethral stricture

Effects of main directions within the tree canopy on fruit quality parameters in apricot cv. Şalak (Prunus armeniaca L.)

This study was conducted to determine the quality differences between the fruits located in the west, east, south and north directions within the tree canopy of apricot variety ; Scedil;alak during 2021-2022. To this end, some physical properties such as fruit weight, stone weight, fruit width, length, and height, fruit flesh thickness, fruit firmness, and fruit L * a * b* * colour values were examined. In addition, chemical properties were also evaluated, including soluble solids content (SSC), juice pH, titratable acidity, and ascorbic acid. Based on the biennial means, the effects of the main directions were statistically significant (p = 0.05) for all the fruit quality traits studied, except for fruit thickness, sphericity, stone weight, and b* * value. The fruits were heavier and larger in the east and south directions, while the fruits with higher firmness scores were harvested in the north and west directions. The south side produced more matte fruits (L*) L * ) and the east side produced fruits with a higher level of red colour (a*) * ) than the other sides. The SSC content of the fruits on the east and south sides was higher than on the other sides. The ascorbic acid content of the fruit was higher on the west and north sides than on the east and south sides. Based on the ripening index, the fruits on the east and south sides were found to be riper than the fruits on the north and west sides. As a result of this study, it is recommended that apricot growers, especially those producing in large orchards and harvesting for several days, first harvest the east and south sides of the canopy and then harvest the remaining other sides.conceptualized and established the methodology, while TK and BDCcontributed at every stage of the study

Effect of Mitomycin - C and Triamcinolone on Preventing Urethral Strictures

ABSTRACT Urethral stricture is a common disease with high recurrence rate. Several manipulations were defined to prevent the recurrence but the results were disappointing. This study aimed to evaluate the efficacy of triamcinolone and mitomycin-C on urethral stricture formation and their effect on inhibition of urethral fibrosis. A total of 24 New Zealand rabbits were divided into 3 groups. Urethras of rabbits were traumatized with pediatric resectoscope. Resection area was irrigated with 10mL saline, swapped with a cotton wool soaked with 0.5mg/mL MMC and injected by 40mg triamcinolone in groups 1, 2 and 3 respectively. Retrograde urethrogram was performed at 28th day of procedure and the urethra was removed for histopathologic evaluation. There were significant differences in urethral diameters and in lumen reduction rate between the control and study groups (p<0.001). Compared to control group, all treatment groups showed mild fibrosis, less collagen bundle irregularity, and lower numbers of fibroblasts (p=0.003). The Tunnel assay showed that the number of apoptotic cells in the submucosal connective tissue was quantitatively higher in control groups (p=0.034). In the view of efficacy and safety, MMC and triamcinolone have the potential to replace the use of stents, clean intermittent catheterization, or long term catheters following internal urethrotomy. There were no statistically significant differences between two agents in terms of preventing urethral stricture formation in the present study. Mitomycin C and triamcinolone decreased the recurrence rates of urethral stricture