5 research outputs found
Nurses\u27 Alumnae Association Bulletin, April 1961
Alumnae Meetings 1960
Social Committee
Clara Melville Scholarship Fund
Bulletin Committee
Private Duty Nurse\u27s Section
Report of the School of Nursing and Nursing Service
Staff Nurses Association
Student Activities
Personal Items of Interest
Expansion of Jefferson
Artificial Kidney Unit
Medical Work in the Congo
Marriages
New Arrivals
Necrology
Annual Giving Fun
Nurses\u27 Alumnae Association Bulletin, April 1959
Alumnae News
Anniversary Class of /34
Article from Pennsylvania Nurse
Committee Reports
Current Events at Jefferson
Greetings from the President
Jefferson Story
Lost Members
Letter - Past President
Marriages
Necrology
New Arrivals
Notices
Pictured - Student Nurses\u27 Residence
Report of the School of Nursing and Nursing Services
Staff Nurses Social Functions
Student Activities
Voluntary Service
Year of Great Activity and Expansio
Nurses Alumni Association Bulletin, Fall 1986
Alumni Calendar
Officers and Committee Chairmen
The President\u27s Message
Treasurer\u27s Report
Nurses\u27 Relief Fund
Scholarship Fund
Surgery for the Unborn- A Nurse\u27s Own Story
Further Remembrances
Martha
From the Tju Historian Old Main
Congratulations to Our Graduates
Advanced Placement Program and Masters in Rehabilitation
Jefferson Surgical Center Opens
Profile in Courage- Update
Fiftieth Anniversary
Happy Birthday
Resume of Minutes of Alumni Association Meetings
Alumni Office News
Committee Reports
Bulletin
Social
Scholarship
Finance
In Memoriam, Names of Deceased Graduates
Luncheon Pictures
Class Notes
Caps, Pins, Transcripts, Class Address Lists
Change of Address Form
1986CAHS Alumni Directory
Bequests
Relief Fund Application
Scholarship Fund Application
Membership Application
Notice, Alumni Luncheo
Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies
The resurgence of yellow fever in South America has prompted vaccination against the etiologic agent, yellow fever virus (YFV). Current vaccines are based on a live-attenuated YF-17D virus derived from a virulent African isolate. The capacity of these vaccines to induce neutralizing antibodies against the vaccine strain is used as a surrogate for protection. However, the sensitivity of genetically distinct South American strains to vaccine-induced antibodies is unknown. We show that antiviral potency of the polyclonal antibody response in vaccinees is attenuated against an emergent Brazilian strain. This reduction was attributable to amino acid changes at two sites in central domain II of the glycoprotein E, including multiple changes at the domain I-domain II hinge, which are unique to and shared among most South American YFV strains. Our findings call for a reevaluation of current approaches to YFV immunological surveillance in South America and suggest approaches for updating vaccines