LetsTalkShots: personalized vaccine risk communication

IntroductionVaccine hesitancy is a global health threat undermining control of many vaccine-preventable diseases. Patient-level education has largely been ineffective in reducing vaccine concerns and increasing vaccine uptake. We built and evaluated a personalized vaccine risk communication website called LetsTalkShots in English, Spanish and French (Canadian) for vaccines across the lifespan. LetsTalkShots tailors lived experiences, credible sources and informational animations to disseminate the right message from the right messenger to the right person, applying a broad range of behavioral theories.MethodsWe used mixed-methods research to test our animation and some aspects of credible sources and personal narratives. We conducted 67 discussion groups (n = 325 persons), stratified by race/ethnicity (African American, Hispanic, and White people) and population (e.g., parents, pregnant women, adolescents, younger adults, and older adults). Using a large Ipsos survey among English-speaking respondents (n = 2,272), we tested animations aligned with vaccine concerns and specific to population (e.g., parents of children, parents of adolescents, younger adults, older adults).ResultsDiscussion groups provided robust feedback specific to each animation as well as areas for improvements across animations. Most respondents indicated that the information presented was interesting (85.5%), clear (96.0%), helpful (87.0%), and trustworthy (82.2%).DiscussionTailored vaccine risk communication can assist decision makers as they consider vaccination for themselves, their families, and their communities. LetsTalkShots presents a model for personalized communication in other areas of medicine and public health

Dimeric and Tetrameric Supramolecular Aggregates of Single-Molecule Magnets via Carboxylate Substitution

[Mn₃]₂ and [Mn₃]₄ supramolecular aggregates of weakly exchange-coupled Mn^III₃ single-molecule magnets (SMMs) with <i>S</i> = 6 have been prepared by carboxylate substitution on [Mn₃O­(O₂CMe)₃(mpko)₃]⁺ [mpkoH = methyl­(pyridine-2-yl) ketone oxime)] with the dicarboxylic acids α-truxillic acid and fumaric acid, respectively. The method opens up a new approach to Mn₃ SMM aggregates of various size and topology

Controlled Dimerization of Mn₁₂ Single-Molecule Magnets

Controlled dimerization of Mn₁₂ single-molecule magnets (SMMs) was achieved via a synthetic route involving a competition between bridging and terminal ligands, namely, diols and alcohols. The reaction using a 1:1 ratio of the competing ligands resulted in the isolation of a new family of covalently linked dimers of Mn₁₂ SMMs. This is the first step toward the controlled growth of SMM oligomeric arrays

Introducing Dimensionality to the Archetypical Mn₁₂ Single-Molecule Magnet: a Family of [Mn₁₂]_<i>n</i> Chains

The [Mn₁₂O₁₂(O₂CR)₁₆(L₄)] family (R = various; L = terminal ligand) of clusters holds a special place in molecular magnetism; they are the most well-studied single-molecule magnets (SMMs). Targeted linkage of these SMMs has now been achieved for the first time. The resulting chain structures have been confirmed crystallographically, and the magnetic properties, up to 1.14 GPa, and high-field electron paramagnetic resonance spectra have been collected and analyzed