ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma.

ZNF750 controls epithelial homeostasis by regulating epidermal-differentiation genes, a role underscored by its pathogenic mutations in esophageal squamous cell cancers (SCCs). However, the precise role of ZNF750 in SCC cell biology remains unclear. In this study, we report that ZNF750 is exclusively deleted, mutated and underexpressed in human SCCs, and low ZNF750 expression is associated with poor survival. Restoration of wildtype, but not mutant ZNF750 protein uniquely inhibited the malignant phenotypes of SCC cells both in vitro and in vivo. Notably, ZNF750 promoted the expression of a long non-coding RNA (TINCR), which mediated both cancer-inhibition and differentiation-induction effects of ZNF750. In addition, ZNF750 potently suppressed cell migration by directly inhibiting the transactivation of LAMC2. Together, our findings characterize ZNF750 as a crucial SCC-specific suppressor and uncover its novel anticancer-associated functions

A review of the neurological complications of breast cancer

Conducting broad assessments of the main burden of breast cancer is the core factor for improving overdiagnosis and overtreatment of breast cancer patients as well as their survival rates. Breast cancer patients may experience neurological complications that cause devastating effects on them. Chemotherapy-induced peripheral neuropathy (CIPN) and neuropathic pain are two of the most reported complications. Objective: This study aims to review the neurological complications of breast cancer and the ways to control and treat them. Comprehensive searches were carried out about the keywords of Breast Cancer. Neurological Complications. and Breast Cancer Consequences. These keywords were searched through the most well-known databases of MEDLINE. PUBMED, Cochrane Library, Best Evidence, CancerLit, HealthSTAR, and LegalTrac. In this regard, 83 articles were chosen to be included in this study from 2010 to 2021. The identification and treatment process of neurologic syndromes are not easy. The main neurologic syndromes which the breast cancer patients face are opsoclonus myoclonus syndrome (OMS), encephalitis, sensorimotor neuropathy, retinopathy, cerebellar degeneration, and stiff-person's syndrome. CIPN and neuropathic pain are among the most prevalent side effects which are categorized as neurological complications and mainly seen 1 year after the management of breast cancer. Aiming to minimize the burden following the treatment of breast cancer, these complications should be diagnosed and treated accurately

Relationship between Hospitals Ownership and Performance Assessment Score of Emergency Departments in the Hospitals Affiliated to Iran University of Medical Sciences 2007

Abstract Introduction: The assessment of healthcare and hospital services is a difficult, critical and multidimensional task, due to its complex nature, variable activities and interactions with multiple issues affected by economic, political and social restrictions. That is to say, hospital assessment must be done by attending of several issues and without any bias. This research was aimed to determine relationship between hospital ownership and performance assessment score of emergency department; according to human resource indices, ethical values, structural issues, medical and non-medical equipments and quality indices. Methods: This research is a descriptive, cross-sectional and applied study. Its population includes all of 51 public and private general hospitals covered by Iran University of Medical Science (IUMS). Documentations and minutes recorded on Accreditation and Assessment Center of Medical in IUMS and also in Healthcare Ministry in the year 2007 are the data sources arranged by a designed form for gathering data. Data are processed by SPSS software and analyzed using independent t-tests. Results: There isn't any meaningful relation between hospital ownership and scores allocated, to ED human resource, ethical values, medical and non-medical equipments, medicals and consumption goods and quality indices in IUMS general hospitals(P v =0.028). But we found a meaningful relation between hospital ownership and structural issues in this general hospital's ED. Conclusion: There are no differences between governmental and private hospitals according to documented scores in 1386. So, it can point to an unbiased assessment by experts, and also adhering of scientific procedures in hospital assessment

ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma

10.1038/onc.2016.377ONCOGENE36162243-225

ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma.

ZNF750 controls epithelial homeostasis by regulating epidermal-differentiation genes, a role underscored by its pathogenic mutations in esophageal squamous cell cancers (SCCs). However, the precise role of ZNF750 in SCC cell biology remains unclear. In this study, we report that ZNF750 is exclusively deleted, mutated and underexpressed in human SCCs, and low ZNF750 expression is associated with poor survival. Restoration of wildtype, but not mutant ZNF750 protein uniquely inhibited the malignant phenotypes of SCC cells both in vitro and in vivo. Notably, ZNF750 promoted the expression of a long non-coding RNA (TINCR), which mediated both cancer-inhibition and differentiation-induction effects of ZNF750. In addition, ZNF750 potently suppressed cell migration by directly inhibiting the transactivation of LAMC2. Together, our findings characterize ZNF750 as a crucial SCC-specific suppressor and uncover its novel anticancer-associated functions

EMERGENCY DEPARTMENT OCCUPANCY ASSESSMENT IN LITHUANIA

Emergency department (ED) occupancy can cause many negative consequences for the quality of patient care. The purpose was to find out the reasons for the increased occupancy of the ED, to determine the appropriate criteria for the assessment of ED occupancy and the limits of wait-ing queues or waiting time. The heads and managers of Lithuanian in-patient health care institutions and ambulance services, in-patient reanimation and intensive care units and emergency departments were interviewed. The reasons for the increased waiting time of the ED and the appropriate criteria for the assessment of ED occupancy were determined: "the number of patients waiting in the queue" and “the estimated waiting time before doctor examination”

Differentiation of human embryonic stem cells into clinically amenable keratinocytes in an autogenic environment

10.1038/jid.2012.384Journal of Investigative Dermatology1333618-628JIDE