Changes in serum levels of Total protein , Albumin and Globulin in patients with Behcet's Disease.

In order to have an idea about some of biochemical changes which might play a role in the pathogenesis of Behcet's disease. Estimation of serum total protein, albumin, globulin and HLA typing were carried out in 70 patients with Behcets disease using colorematric, mathematic & microlymphocytotoxicity tests respectively, compared with 35 patients with recurrent oral ulcers, and 35 healthy control group. Hyperproteinemia, hyperglobulinemia with hypoalbuminemia were observed in those patients in comparison to control group

The Association of Myasthenia Gravis with HLA class II Antigens in Iraqi Patients

The nature and intensity of the association of myasthenia gravis (MG) with distinct human leukocyte antigen (HLA) haplotypes differ between ethnic populations, so this study determined the association of HLA class II antigens with myasthenia gravis (MG) in Iraq.The study included Iraqi patients diagnosed with MG and two control groups the first of 54 insulin dependent diabetes mellitus patients and the second of 237 subjects as a normal control group. The test used was microlymphocytotoxicity test.The work was done in the Teaching Laboratories/Medical City/Baghdad.Results: positive associations were observed (etiological risk factors) as follows: 1. HLA-DR locus showed one positively associated allele when compared to healthy control and this was HLA-DR3 (RR: 21.05, EF0.73, & P value ? 0.05), While when compared to IDDM control no significant association appeared (since the same allele is positively associated with IDDM). 2. HLA-DQ locus showed only one positively associated allele when compared to healthy control; this was HLA-DQ2 (RR 4.67, EF 0.50, and P value ? 0.05). While no significant association appeared when compared to IDDM control. Other important clinical association were observed; association with age, gender, strong stressful events, thymoma, and other autoimmune disorders. Conclusion: The positively associated antigens which were found as follows HLA-DR3 and HLA-DQ2, while no negative association was detected

Correlation between Interleukin-4 and Interleukin-6 and auto antibodies in Systemic Lupus Erythematosus.

Background: There is a general acceptance which illustrated that auto antibodies act as a central immunological disturbance in most of the auto immune diseases, among these auto immune diseaselies the SLE Patients and Methods: Thirty five patients with SLE were compared to twenty age and sex matched, control subjects and studied for the presence of auto antibodies, plus IL-4 and IL-6 using Elisa method and immune fluorescent method (for ANA only) Results: Data showed that IL-6 detectable levels were statistically significant in patients with positive anti ds-DNA, but not significant statistically in ANA positive patients although it was detected in 24 (70.6%) of positive ANA patients, while there was no statistically significant correlation between IL- 4 detectable level and autoantibodies production. Conclusion: There is apparently a positive correlation between IL-6 and anti ds DNA production in lupus patients

Possible Role of Interleukins 6 and 10 in Colorectal Carcinoma in Iraqi Patients

Background : It is quite accepted that interleukins (IL) in general play a crucial role in response to injuy , infection and on cogenic trans formation , among there are IL-6 and ILJO. Aim of this study is to find out the possible role of IL_ and IL, 10 in colo rectaI carcima in Iraqi patients. Subjects and Methods: forty patients with colorectal cancer (CRC) composed with 30 healthy controls were enrolled in this study. Serum conc. Of IL-6 and IL -lOwere estimated in both groups using ELIZA technique. Results: Serem levels of IL-6 and IL-10 were significantly increased (P<0.001) in compassion with control group. Conclusion: these cytokins could be used as a markers for tumor progression

antimicrobial susceptibility test of microorganisms isolated from sputum culture of leukaemic patients with lower respiratory tract infections

Background

HLA class-1 molecules in Iraqi patients with rheumatoid arthritis . A sporadic & familial study

Baghdad

HLA-DR and DQ Antigens in Iraqi Patients with Behget's Disease

Background