Can Health Foreign Assistance Break the Medical Brain Drain ?

This paper analyse the impact of health foreign assistance on physicians' brain drain. We use the database from Bhargava and Docquier (2008) to explain physicians' brain drain and health foreign assistance from 1995 to 2003 using a bilateral gravity equation model. In the first time, we propose to investigate the direct and reverse impact of health assistance through simultaneous equation model with Three-Stage Least Squares (3SLS) methodology and highlight a significant negative effect of health foreign assistance on the medical brain whereas emigration rate of doctor increases the amount of health aid received by recipient countries. In a second time, we analyzed the indirect effect of health aid via epidemics prevalence through the death rate per 1000 people. We find that health aid plays a key role in the improvement of vaccination, treatment and prevention which may reduce death rate and, finally, decreases the physicians emigration rates. These findings confirm the efficiency of health foreign aid to weaken the vicious circle of physicians drain.International migration ; physicians emigration rates ; foreign aid ; health foreign assistance ; simultaneous equation model ; Three Stage Least Squares ; gravity equation model

Can Foreign Health Assistance Reduce the Medical Brain Drain?

This paper analyses the impact of foreign health aid on the emigration rates of physicians. We use a panel database to investigate the emigration of physicians from 192 source countries to 17 destination countries between 1995 and 2004. First, we investigate the direct impact of health assistance using the generalised method of moments (GMM) and highlight a significant negative effect of foreign health assistance on the medical brain drain. Moreover, we analyse whether this effect of health aid is more effective in a context of good governance. We find that health aid is more effective at reducing physicians' emigration rates when the levels of corruption and inflation are low.International Migration, Physicians Emigration Rates, Foreign Aid, Foreign health assistance

Can Health Foreign Assistance Break the Medical Brain Drain?

This paper analyses the impact of health foreign assistance on physicians' brain drain. We use the database from Bhargava and Docquier (2008) to explain physicians' brain drain and health foreign assistance from 1995 to 2003 using a bilateral gravity equation model. In the first time, we propose to investigate the direct and reverse impact of health assistance through Simultaneous Equation Model with Three-Stage Least Squares (3SLS) methodology and highlight a significant negative effect of health foreign assistance on the medical brain drain whereas emigration rate of doctor increases the amount of health aid received by recipient countries. In a second time, we analyzed the indirect effect of health aid via epidemics prevalence through the death rate per 1000 people. We find that health aid plays a key role in the improvement of vaccination, treatment and prevention which may reduce death rate and, finally, decreases the physicians emigration rates. These findings confirm the efficiency of health foreign aid to weaken the vicious circle of physicians drain. --International Migration,Physicians Emigration Rates,Foreign Aid,Health foreign assistance,Simultaneous Equation Model,Three Stage Least Squares,Gravity Equation model

Labour Standards and Migration : do labour conditions matter ?

We study in this paper the interactions between migration rates and the level of labour standards. We use an augmented version of the Grogger and Hanson (2008) model, adding the level of working conditions into the specification. Our hypothesis is that the differential of working conditions may be a complementary determinant of migration. In a first time, we test the influence of labour standards in countries of origin using a database on emigration rates built by Defoort (2006) for the period 1975-1995. For labour standards, we built an original index with a temporal dimension. We find that labour standards in the source countries does not have a significant impact on the probability of moving abroad. In a second time, we use a bilateral migration database built by Marfouk and Docquier (2004) in order to test the influence of labour standards in destination countries. If labour standards in the source countries do not have a significant impact on migration flows, level of labour conditions in destination countries have multiple effects on bilateral migration flows. Social protection or protection of collective relations have a positive impact on migration, while job and employment protection laws have the opposite effect. We also find that high-skilled workers are much more sensitive to social security benefits while low skilled workers are more attracted by a protective job and employment legislation.Migration, labour standards, brain-drain, labour markets.

Employment Protection and Migration

We argue in this paper that labor market institutions, and more particularly employment protection (EPL), are an important determinant of migration. Using a bilateral migration database, we empirically show that the employment protection di fferential has a negative impact on bilateral ows. Contrary to pop- ular wisdom which assumes that migrants look for a more protected market, we show that migrants tend to move to countries where employment protection is close to that of their country of origin. Relative preferences over wages or employment, or a distinct impact on wages and employment may explain such results. We also show that these e ffects are stronger for high-skilled workers

Labour Standards and Migration : do labour conditions matter ?

URL des documents de travail ; http://ces.univ-paris1.fr/cesdp/CESFramDP2009.htmClassification JEL : J8, O1, F2.Documents de travail du Centre d'Economie de la Sorbonne 2009.48 - ISSN : 1955-611XWe study in this paper the interactions between migration rates and the level of labour standards. We use an augmented version of the Grogger and Hanson (2008) model, adding the level of working conditions into the specification. Our hypothesis is that the differential of working conditions may be a complementary determinant of migration. In a first time, we test the influence of labour standards in countries of origin using a database on emigration rates built by Defoort (2006) for the period 1975-1995. For labour standards, we built an original index with a temporal dimension. We find that labour standards in the source countries does not have a significant impact on the probability of moving abroad. In a second time, we use a bilateral migration database built by Marfouk and Docquier (2004) in order to test the influence of labour standards in destination countries. If labour standards in the source countries do not have a significant impact on migration flows, level of labour conditions in destination countries have multiple effects on bilateral migration flows. Social protection or protection of collective relations have a positive impact on migration, while job and employment protection laws have the opposite effect. We also find that high-skilled workers are much more sensitive to social security benefits while low skilled workers are more attracted by a protective job and employment legislation.Nous étudions dans cet article les interactions entre les taux de migration et le niveau des normes du travail. Nous utilisons pour cela une version augmentée du modèle de Grogger et Hanson (2008), en ajoutant le niveau des conditions de travail dans la spécification. Notre hypothèse est que le différentiel de conditions de travail constituerait un facteur additionnel de migration. Dans un premier temps, nous testons l'influence des normes du travail dans les pays d'origine en utilisant une base de données sur les taux d'émigration construit par Defoort (20069) pour la période 1975-1995. Pour les normes du travail, nous construisons un index original intégrant une dimension temporelle. Nous constatons que les normes du travail dans le pays source n'a pas d'impact significatif sur la probabilité de migrer à l'étranger. Dans un deuxième temps, nous utilisons une base de données sur les migrations bilatérales construit par Marfouk et Docquier (2004) afin de tester l'influence des normes du travail dans les pays de destination. Si les normes du travail dans les pays d'origine n'ont pas d'impact significatif sur les flux migratoires, le niveau des normes du travail dans les pays de destination ont des effets multiples sur les flux migratoires bilatéraux. La protection sociale ou la protection des négociations collectives ont un impact positif sur la migration, alors que les lois visant à protéger l'emploi ont l'effet inverse. Nous constatons également que les travailleurs hautement qualifiés les travailleurs sont beaucoup plus sensibles aux prestations de sécurité sociale alors que les travailleurs peu qualifiés sont plus attirés par une législation protectrice en matière d'emploi

Analysis of Mitochondrial Protein Synthesis: De Novo Translation, Steady-State Levels, and Assembled OXPHOS Complexes.

Mitochondria are multifunctional organelles with their own genome and protein synthesis machinery. The 13 proteins encoded by mitochondrial DNA (mtDNA) are core subunits of the oxidative phosphorylation (OXPHOS) system producing the majority of cellular ATP. Yet most mitochondrial proteins are encoded by nuclear genes, synthesized by cytosolic ribosomes, and imported into mitochondria. Therefore, disturbances in cytosolic proteostasis have consequences on the gene expression and synthesis of mtDNA-encoded proteins and overall on mitochondrial function. Internal and environmental factors such as mutations, aging, oxidative stress, and toxic agents can affect the translation and the stability of mitochondrial proteins and lead to OXPHOS dysfunction. Here, methods for analysis of mitochondrial translation rate and protein stability using radioactive and non-radioactive technique as well as the methods for studying steady-state levels and assembly of OXPHOS complexes are described. © 2018 by John Wiley & Sons, Inc

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research.

In recent years, tetracyclines, such as doxycycline, have become broadly used to control gene expression by virtue of the Tet-on/Tet-off systems. However, the wide range of direct effects of tetracycline use has not been fully appreciated. We show here that these antibiotics induce a mitonuclear protein imbalance through their effects on mitochondrial translation, an effect that likely reflects the evolutionary relationship between mitochondria and proteobacteria. Even at low concentrations, tetracyclines induce mitochondrial proteotoxic stress, leading to changes in nuclear gene expression and altered mitochondrial dynamics and function in commonly used cell types, as well as worms, flies, mice, and plants. Given that tetracyclines are so widely applied in research, scientists should be aware of their potentially confounding effects on experimental results. Furthermore, these results caution against extensive use of tetracyclines in livestock due to potential downstream impacts on the environment and human health

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

Sirt3 is a mitochondrial sirtuin, predominantly expressed in highly metabolic tissues. Germline ablation of Sirt3 has major metabolic consequences, including increased susceptibility to metabolic damage and oxidative stress after high fat feeding. In order to determine the contribution of liver and skeletal muscle to these phenotypes, we generated muscle-specific Sirt3 (Sirt3skm−/−) and liver-specific Sirt3 (Sirt3hep−/−) knock-out mice. Despite a marked global hyperacetylation of mitochondrial proteins, Sirt3skm−/− and Sirt3hep−/− mice did not manifest any overt metabolic phenotype under either chow or high fat diet conditions. Similarly, there was no evidence for increased oxidative stress in muscle or liver when Sirt3 was ablated in a tissue-specific manner. These observations suggest that the mitochondrial hyperacetylation induced by Sirt3-deletion in a tissue specific manner is not necessarily linked to mitochondrial dysfunction and does not recapitulate the metabolic abnormalities observed in the germline Sirt3 knock-out mice

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance.

MAF1 is a global repressor of RNA polymerase III transcription that regulates the expression of highly abundant noncoding RNAs in response to nutrient availability and cellular stress. Thus, MAF1 function is thought to be important for metabolic economy. Here we show that a whole-body knockout of Maf1 in mice confers resistance to diet-induced obesity and nonalcoholic fatty liver disease by reducing food intake and increasing metabolic inefficiency. Energy expenditure in Maf1(-/-) mice is increased by several mechanisms. Precursor tRNA synthesis was increased in multiple tissues without significant effects on mature tRNA levels, implying increased turnover in a futile tRNA cycle. Elevated futile cycling of hepatic lipids was also observed. Metabolite profiling of the liver and skeletal muscle revealed elevated levels of many amino acids and spermidine, which links the induction of autophagy in Maf1(-/-) mice with their extended life span. The increase in spermidine was accompanied by reduced levels of nicotinamide N-methyltransferase, which promotes polyamine synthesis, enables nicotinamide salvage to regenerate NAD(+), and is associated with obesity resistance. Consistent with this, NAD(+) levels were increased in muscle. The importance of MAF1 for metabolic economy reveals the potential for MAF1 modulators to protect against obesity and its harmful consequences