Seasonal Study of the Kako River Discharge Dynamics into Harima Nada Using a Coupled Atmospheric–Marine Model

Pintos Andreoli V., Shimadera H., Yasuga H., et al. Seasonal Study of the Kako River Discharge Dynamics into Harima Nada Using a Coupled Atmospheric–Marine Model. Water (Switzerland) 16, 614 (2024); https://doi.org/10.3390/w16040614.This study developed a coupled atmospheric–marine model using the COAWST model system for the Harima Nada area between spring 2010 and winter 2011 to evaluate the seasonal influence of the Kako River’s discharge in the sea. The Kako River is one of the largest rivers in southwest Japan, contributing almost half of the freshwater discharged in the Harima Nada region in the Seto Inland Sea. Validation was conducted for the entire period, showing a good performance for the atmospheric and marine variables selected. Multiple experiments injecting an inert tracer in the Kako River estuary were performed to simulate the seasonal river water distribution from the estuary into the sea and to analyze the seasonal differences in concentration patterns and mean residence times in Harima Nada. Because the study area is shallow, the results were evaluated at the surface and 10 m depth layers and showed significant seasonal differences in tracer distribution, circulation patterns, and mean residence times for the region. On the other hand, differences seemed to not be significant during the same season at different depths. The obtained results also agreed with the area’s natural water circulation, showing that the Kako River waters tend to distribute towards the west coast of Harima Nada in the warmer seasons but shift towards the east in winter. The influence of the Kako River in the center of the study area is seasonal and strongly dependent on the direction of the horizontal velocities more than their magnitude. The mean residence times varied seasonally from approximately 30 days in spring to 12 days in fall. The magnitude of the horizontal velocity was found to be maximum during summer when circulation patterns at the surface and 10 m depth in the central part of Harima Nada also seem to promote the strongest horizontal and vertical mixes

Polychlorinated biphenyl (118) activates osteoclasts and induces bone resorption in goldfish

To analyze the effect of polychlorinated biphenyl (PCB) 118 on fish bone metabolism, we examined osteoclastic and osteoblastic activities, as well as plasma calcium levels, in the scales of PCB (118)-injected goldfish. In addition, effect of PCB (118) on osteoclasts and osteoblasts was investigated in vitro. Immature goldfish, in which the endogenous effects of sex steroids are negligible, were used. PCB (118) was solubilized in dimethyl sulfoxide at a concentration of 10 ppm. At 1 and 2 days after PCB (118) injection (100 ng/g body weight), both osteoclastic and osteoblastic activities, and plasma calcium levels were measured. In an in vitro study, then, both osteoclastic and osteoblastic activities as well as each marker mRNA expression were examined. At 2 days, scale osteoclastic activity in PCB (118)-injected goldfish increased significantly, while osteoblastic activity did not change significantly. Corresponding to osteoclastic activity, plasma calcium levels increased significantly at 2 days after PCB (118) administration. Osteoclastic activation also occurred in the marker enzyme activities and mRNA expressions in vitro. Thus, we conclude that PCB (118) disrupts bone metabolism in goldfish both in vivo and in vitro experiments. © 2012 The Author(s)

Seasonal Study of the Kako River Discharge Dynamics into Harima Nada Using a Coupled Atmospheric–Marine Model

This study developed a coupled atmospheric–marine model using the COAWST model system for the Harima Nada area between spring 2010 and winter 2011 to evaluate the seasonal influence of the Kako River’s discharge in the sea. The Kako River is one of the largest rivers in southwest Japan, contributing almost half of the freshwater discharged in the Harima Nada region in the Seto Inland Sea. Validation was conducted for the entire period, showing a good performance for the atmospheric and marine variables selected. Multiple experiments injecting an inert tracer in the Kako River estuary were performed to simulate the seasonal river water distribution from the estuary into the sea and to analyze the seasonal differences in concentration patterns and mean residence times in Harima Nada. Because the study area is shallow, the results were evaluated at the surface and 10 m depth layers and showed significant seasonal differences in tracer distribution, circulation patterns, and mean residence times for the region. On the other hand, differences seemed to not be significant during the same season at different depths. The obtained results also agreed with the area’s natural water circulation, showing that the Kako River waters tend to distribute towards the west coast of Harima Nada in the warmer seasons but shift towards the east in winter. The influence of the Kako River in the center of the study area is seasonal and strongly dependent on the direction of the horizontal velocities more than their magnitude. The mean residence times varied seasonally from approximately 30 days in spring to 12 days in fall. The magnitude of the horizontal velocity was found to be maximum during summer when circulation patterns at the surface and 10 m depth in the central part of Harima Nada also seem to promote the strongest horizontal and vertical mixes

The Kadota Fund International Forum 2004 - Clinical group consensus

The results from experimental studies indicate that hyperthermia is both an effective complementary treatment to, and a strong sensitiser of, radiotherapy and many cytotoxic drugs. Since the first international hyperthermia conference in 1975, Washington DC, techniques to increase tumour temperature have been developed and tested clinically. Hyperthermia can be applied by several methods: local hyperthermia by external or internal energy sources, perfusion hyperthermia of organs, limbs, or body cavities, and whole body hyperthermia. The clinical value of hyperthermia in combination with other treatment modalities has been shown by randomised trials. Significant improvement in clinical outcome has been demonstrated for tumours of the head and neck, breast, brain, bladder, cervix, rectum, lung, oesophagus, for melanoma and sarcoma. The addition of hyperthermia resulted in remarkably higher (complete) response rates, accompanied by improved local tumour control rates, better palliative effects, and/or better overall survival rates. Toxicity from hyperthermia cannot always be avoided, but is usually of limited clinical relevance. In spite of these good clinical results, hyperthermia has received little attention. Problems with acceptance concern the limited availability of equipment, the lack of awareness concerning clinical results, and the lack of financial resources. In this paper the most relevant literature describing the clinical effects of hyperthermia is reviewed and discussed, and means to overcome the lack of awareness and use of this modality is described