Chemical and biological investigations of Dillenia indica Linn.

A total of four compounds namely, lupeol (1), betulinaldehyde (2), betulinic acid (3) and stigmasterol (4) were isolated from the stem extract of Dillenia indica Linn. The structures of the isolated compounds (1-4) were established by extensive spectroscopic studies. The crude methanolic extracts and its n-hexane, carbon tetrachloride, dichloromethane and chloroform soluble partitionates demonstrated weak antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria and fungi. The extractives revealed significant cytotoxic activity when tested by brine shrimp lethality bioassay. In addition, the extractives exhibited significant free radical scavenging activity when compared with the standard drug ascorbic acid.   

Chemical and biological investigations of Dillenia indica Linn.

A total of four compounds namely, lupeol (1), betulinaldehyde (2), betulinic acid (3) and stigmasterol (4) were isolated from the stem extract of Dillenia indica Linn. The structures of the isolated compounds (1-4) were established by extensive spectroscopic studies. The crude methanolic extracts and its n-hexane, carbon tetrachloride, dichloromethane and chloroform soluble partitionates demonstrated weak antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria and fungi. The extractives revealed significant cytotoxic activity when tested by brine shrimp lethality bioassay. In addition, the extractives exhibited significant free radical scavenging activity when compared with ascorbic acid

Short Communications

The petroleum ether, chloroform and methanol crude extracts of the two different plant parts (leaves and bark) of Mirabilis jalapa (Nyctaginaceae) were screened for cytotoxicity by brine shrimp lethality bioassay and the crude methanol extract of the bark was screened for antioxidant activity using the 1, 1-diphenyl-2picrylhydrazyl-hydrate (DPPH) free radical scavenging assay. The petroleum ether extract of the bark showed significant cytotoxic activity with the LC50 value 8.12 g/ml compared to vincristine sulphate (LC50 0.33 g/ml). On the other hand, the methanol crude extract of the bark showed mild antioxidant activity with the IC50 value 598.02 µg/ml compared to ascorbic acid(IC50 70.985 g/ml). Above results suggest moderate cytotoxic and antioxidant activity of the extract