Curriculum Mapping: Bringing Evidence-Based Frameworks to Legal Education

This article explains the concept of curriculum mapping as used in the education profession and explains how it was applied in a mapping initiative at the NSU Law Center. Curriculum mapping is a process by which education professionals “document their own curriculum, then share and examine each other’s curriculums for gaps, overlaps, redundancies and new learning, creating a coherent, consistent, curriculum within and across areas that is ultimately aligned to standards and responsive to student data and other initiatives.” While this process has been used for many years in other areas of education, it is fairly new to legal education. This article explains the concepts, puts them into the context of other reforms currently happening in legal education, and through documenting our own experiences, gives a step-by-step primer on how to bring this useful tool to any law school to make evidence-based changes to a law school curriculum

Libre culture: meditations on free culture

Libre Culture is the essential expression of the free culture/copyleft movement. This anthology, brought together here for the first time, represents the early groundwork of Libre Society thought. Referring to the development of creativity and ideas, capital works to hoard and privatize the knowledge and meaning of what is created. Expression becomes monopolized, secured within an artificial market-scarcity enclave and finally presented as a novelty on the culture industry in order to benefit cloistered profit motives. In the way that physical resources such as forests or public services are free, Libre Culture argues for the freeing up of human ideas and expression from copyright bulwarks in all forms

Identification of a key residue for Oligomerisation and pore-formation of Clostridium perfringens NetB

Necrotic enteritis toxin B (NetB) is a β-pore-forming toxin produced by Clostridium perfringens and has been identified as a key virulence factor in the pathogenesis of avian necrotic enteritis, a disease causing significant economic damage to the poultry industry worldwide. In this study, site-directed mutagenesis was used to identify amino acids that play a role in NetB oligomerisation and pore-formation. NetB K41H showed significantly reduced toxicity towards LMH cells and human red blood cells relative to wild type toxin. NetB K41H was unable to oligomerise and form pores in liposomes. These findings suggest that NetB K41H could be developed as a genetic toxoid vaccine to protect against necrotic enteritis

The Stargazin-Related Protein {gamma}7 Interacts with the mRNA-Binding Protein Heterogeneous Nuclear Ribonucleoprotein A2 and Regulates the Stability of Specific mRNAs, Including CaV2.2

The role(s) of the novel stargazin-like {gamma}-subunit proteins remain controversial. We have shown previously that the neuron-specific {gamma}7 suppresses the expression of certain calcium channels, particularly CaV2.2, and is therefore unlikely to operate as a calcium channel subunit. We now show that the effect of {gamma}7 on CaV2.2 expression is via an increase in the degradation rate of CaV2.2 mRNA and hence a reduction of CaV2.2 protein level. Furthermore, exogenous expression of {gamma}7 in PC12 cells also decreased the endogenous CaV2.2 mRNA level. Conversely, knockdown of endogenous {gamma}7 with short-hairpin RNAs produced a reciprocal enhancement of CaV2.2 mRNA stability and an increase in endogenous calcium currents in PC12 cells. Moreover, both endogenous and expressed {gamma}7 are present on intracellular membranes, rather than the plasma membrane. The cytoplasmic C terminus of {gamma}7 is essential for all its effects, and we show that {gamma}7 binds directly via its C terminus to a heterogeneous nuclear ribonucleoprotein (hnRNP A2), which also binds to a motif in CaV2.2 mRNA, and is associated with native CaV2.2 mRNA in PC12 cells. The expression of hnRNP A2 enhances CaV2.2 IBa, and this enhancement is prevented by a concentration of {gamma}7 that alone has no effect on IBa. The effect of {gamma}7 is selective for certain mRNAs because it had no effect on {alpha}2{delta}-2 mRNA stability, but it decreased the mRNA stability for the potassium-chloride cotransporter, KCC1, which contains a similar hnRNP A2 binding motif to that in CaV2.2 mRNA. Our results indicate that {gamma}7 plays a role in stabilizing CaV2.2 mRNA

Supersymmetry and Electroweak Breaking in the Interval

Hypermultiplets are considered in the five-dimensional interval where all fields are continuous and the boundary conditions are dynamically obtained from the action principle. The orbifold boundary conditions are obtained as particular cases. We can interpret the Scherk-Schwarz supersymmetry breaking as a misalignment of boundary conditions while a new source of supersymmetry breaking corresponding to a mismatch of different boundary parameters is identified. The latter can be viewed as coming from boundary supersymmetry breaking masses for hyperscalars and the nature of the corresponding supersymmetry breaking parameter is analyzed. For some regions of the parameter space where supersymmetry is broken (either by Scherk-Schwarz boundary conditions or by boundary hyperscalar masses) electroweak symmetry breaking can be triggered at the tree level.Comment: 28 pages, 5 figure

Evidence for a colour dependence in the size distribution of main belt asteroids

We present the results of a project to detect small (~1 km) main-belt asteroids with the 3.6 meter Canada-France-Hawaii Telescope (CFHT). We observed in 2 filters (MegaPrime g' and r') in order to compare the results in each band. Owing to the observational cadence we did not observe the same asteroids through each filter and thus do not have true colour information. However strong differences in the size distributions as seen in the two filters point to a colour-dependence at these sizes, perhaps to be expected in this regime where asteroid cohesiveness begins to be dominated by physical strength and composition rather than by gravity. The best fit slopes of the cumulative size distributions (CSDs) in both filters tend towards lower values for smaller asteroids, consistent with the results of previous studies. In addition to this trend, the size distributions seen in the two filters are distinctly different, with steeper slopes in r' than in g'. Breaking our sample up according to semimajor axis, the difference between the filters in the inner belt is found to be somewhat less pronounced than in the middle and outer belt, but the CSD of those asteroids seen in the r' filter is consistently and significantly steeper than in g' throughout. The CSD slopes also show variations with semimajor axis within a given filter, particularly in r'. We conclude that the size distribution of main belt asteroids is likely to be colour dependent at kilometer sizes and that this dependence may vary across the belt.Comment: 28 pages, 5 figures, submitted to the Astronomical Journa

A 610-MHz survey of the ELAIS-N1 field with the Giant Metrewave Radio Telescope - Observations, data analysis and source catalogue

Observations of the ELAIS-N1 field taken at 610 MHz with the Giant Metrewave Radio Telescope are presented. Nineteen pointings were observed, covering a total area of 9 square degrees with a resolution of 6" x 5", PA +45 deg. Four of the pointings were deep observations with an rms of 40 microJy before primary beam correction, with the remaining fifteen pointings having an rms of 70 microJy. The techniques used for data reduction and production of a mosaicked image of the region are described, and the final mosaic is presented, along with a catalogue of 2500 sources detected above 6 sigma. This work complements the large amount of optical and infrared data already available on the region. We calculate 610-MHz source counts down to 270 microJy, and find further evidence for the turnover in differential number counts below 1 mJy, previously seen at both 610 MHz and 1.4 GHz.Comment: 12 pages, 18 figures, two tables. Table 1 can be found in full via http://www.mrao.cam.ac.uk/surveys/ . Accepted for publication in MNRA

Hidden Curriculum of Legal Education: Toward a Holistic Model for Reform, The

The following section of this article directly addresses the notion of the hidden curriculum and why this construct is essential for legal educators to consider as they contemplate reforms. Core principles of curriculum theory will then be briefly discussed as a precursor to the subsequent section that addresses the notion of a transdisciplinary curriculum. A transdisciplinary perspective will offer a holistic lens for considering law school curriculum. Finally, such notions as curriculum mapping offer tangible solutions to addressing the challenge of preparing practice-ready graduates in the legal profession

Stochastic model for population migration and the growth of human settlements during the Neolithic transition

We present a stochastic two-population model that describes the migration and growth of semisedentary foragers and sedentary farmers along a river valley during the Neolithic transition. The main idea is that random migration and transition from a sedentary to a foraging way of life, and backwards, is strongly coupled with the local crop production and associated degradation of land. We derive a nonlinear integral equation for the population density coupled with the equations for the density of soil nutrients and crop production. Our model provides a description of the formation of human settlements along the river valley. The numerical results show that the individual farmers have a tendency for aggregation and clustering. We show that the large-scale pattern is a transient phenomenon which eventually disappears due to land degradation