Behçet's disease with slowly enlarging midbrain mass on MRI: resolution following steroid therapy

We describe a case of Behçet's disease with a slowly enlarging midbrain mass on magnetic resonance imaging, which resolved after 4 months of oral steroids

Pathogenesis of progressive multiple sclerosis

Letters to the Edito

Early lesion of multiple sclerosis

No abstract availabl

Changing activity in MS lesions: An MRI study

No abstract availabl

Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis

From an extensive serial magnetic resonance imaging (MRI) study in multiple sclerosis (MS) we have identified 4 cases in which disruption of the blood-brain barrier, as detected by gadolinium-DTPA enhancement, preceded other MRI abnormalities and in 1 case clinical evidence of the new lesion. This supports the view that a defect in the blood-brain barrier, and therefore inflammation, is an early and possibly crucial event in the pathogenesis of the new lesion in MS. These cases showed a marked discrepancy between MRI abnormality and symptoms. The mechanisms contributing to this disparity are discussed, and it is concluded that far from being surprising it is to be expected