Techno-economic assessment of photovoltaic (PV) and building integrated photovoltaic/thermal (BIPV/T) system retrofits in the Canadian housing stock

Techno-economic impact of retrofitting houses in the Canadian housing stock with PV and BIPV/T systems is evaluated using the Canadian Hybrid End-use Energy and Emission Model. Houses with south, south-east and south-west facing roofs are considered eligible for the retrofit since solar irradiation is maximum on south facing surfaces in the northern hemisphere. The PV system is used to produce electricity and supply the electrical demand of the house, with the excess electricity sold to the grid in a net-metering arrangement. The BIPV/T system produces electricity as well as thermal energy to supply the electrical as well as the thermal demands for space and domestic hot water heating. The PV system consists of PV panels installed on the available roof surface while the BIPV/T system adds a heat pump, thermal storage tank, auxiliary heater, domestic hot water heating equipment and hydronic heat delivery system, and replaces the existing heating system in eligible houses. The study predicts the energy savings, GHG emission reductions and tolerable capital costs for regions across Canada. Results indicate that the PV system retrofit yields 3% energy savings and 5% GHG emission reduction, while the BIPV/T system yields 18% energy savings and 17% GHG emission reduction in the Canadian housing stock. While the annual electricity use slightly increases, the fossil fuel use of the eligible houses substan

Саратовскому научному обществу дерматовенерологов - 100 лет

The article describes major historic stages of the Saratov Research Association of Dermatologists and venereologists. The authors describe the Society’s role in the establishment and development of the dermatovenerological service, health education, prevention and improvement of measures aimed at fighting sexually transmitted and contagious skin diseases as well as training highly skilled personnel and promoting health care services in the region.В статье представлены основные исторические этапы деятельности научного общества дерматовенерологов Саратовской области. Показана его роль в становлении и развитии дерматовенерологической службы, санитарного просвещения, профилактики и совершенствовании методов борьбы с инфекциями, передаваемыми половым путем, и заразными кожными заболеваниями, а также в подготовке высококвалифицированных кадров и оказании помощи практическому здравоохранению региона

Action-gradient-minimizing pseudo-orbits and almost-invariant tori

Transport in near-integrable, but partially chaotic, $1 1/2$ degree-of-freedom Hamiltonian systems is blocked by invariant tori and is reduced at \emph{almost}-invariant tori, both associated with the invariant tori of a neighboring integrable system. "Almost invariant" tori with rational rotation number can be defined using continuous families of periodic \emph{pseudo-orbits} to foliate the surfaces, while irrational-rotation-number tori can be defined by nesting with sequences of such rational tori. Three definitions of "pseudo-orbit," \emph{action-gradient--minimizing} (AGMin), \emph{quadratic-flux-minimizing} (QFMin) and \emph{ghost} orbits, based on variants of Hamilton's Principle, use different strategies to extremize the action as closely as possible. Equivalent Lagrangian (configuration-space action) and Hamiltonian (phase-space action) formulations, and a new approach to visualizing action-minimizing and minimax orbits based on AGMin pseudo-orbits, are presented.Comment: Accepted for publication in a special issue of Communications in Nonlinear Science and Numerical Simulation (CNSNS) entitled "The mathematical structure of fluids and plasmas : a volume dedicated to the 60th birthday of Phil Morrison

Techno-economic assessment of solar assisted heat pump system retrofit in the Canadian housing stock

The techno-economic feasibility of retrofitting existing Canadian houses with solar assisted heat pump (SAHP) is investigated. The SAHP architecture is adopted from previous studies conducted for the Canadian climate. The system utilizes two thermal storage tanks to store excess solar energy for use later in the day. The control strategy is defined in order to prioritise the use of solar energy for space and domestic hot water heating purposes. Due to economic and technical constraints a series of eligibility criteria are introduced for a house to qualify for the retrofit. A model was built in ESP-r and the retrofit was introduced into all eligible houses in the Canadian Hybrid Residential End-Use Energy and GHG Emissions model. Simulations were conducted for an entire year to estimate the annual energy savings, and GHG emission reductions. Results show that the SAHP system performance is strongly affected by climatic conditions, auxiliary energy sources and fuel mixture for electricity generation. Energy consumption and GHG emission of the Canadian housing stock can be reduced by about 20% if all eligible houses receive the SAHP system retrofit. Economic analysis indicates that the incentive measures will likely be necessary to promote the SAHP system in the Canadian residential market

Techno-economic feasibility evaluation of air to water heat pump retrofit in the Canadian housing stock

This study was conducted to assess the techno-economic feasibility of converting the Canadian housing stock (CHS) into net/near zero energy buildings by introducing and integrating high efficient and renewable/alternative energy technologies in new construction and existing houses. Performance assessment of energy retrofit and renewable/alternative energy technologies in existing houses in regional and national scale is necessary to devise feasible strategies and incentive measures. The Canadian Hybrid Residential End-Use Energy and GHG Emissions model (CHREM) that utilizes a bottom-up modeling approach is used to investigate the techno-economic feasibility of air to water heat pump retrofit in the Canadian housing stock. The proposed energy retrofit includes an air to water heat pump, auxiliary boiler, thermal storage tank, hydronic heat delivery and domestic hot water (DHW) heating. Energy savings, GHG emission changes and economic feasibility of the air source heat pump retrofit are considered in this study. Results show that there is a potential to reduce 36% of energy consumption and 23% of GHG emissions of the CHS if all eligible houses undertake the retrofit. Economic analysis indicates that the feasibility of air to water heat pump systems is strongly affected by the current status of primary energy use for electricity generation and space and DHW heating as well as energy prices and economic conditions. Legislation, economic incentives and education for homeowners are necessary to enhance the penetration level of air to water heat pump retrofits in the CHS

Systematic review of economic evaluations and cost analyses of guideline implementation strategies

Objectives To appraise the quality of economic studies undertaken as part of evaluations of guideline implementation strategies; determine their resources use; and recommend methods to improve future studies. Methods Systematic review of economic studies undertaken alongside robust study designs of clinical guideline implementation strategies published (1966-1998). Studies assessed against the BMJ economic evaluations guidelines for each stage of the guideline process (guideline development, implementation and treatment). Results 235 studies were identified, 63 reported some information on cost. Only 3 studies provided evidence that their guideline was effective and efficient. 38 reported the treatment costs only, 12 implementation and treatment costs, 11 implementation costs alone, and two guideline development, implementation and treatment costs. No study gave reasonably complete information on costs. Conclusions Very few satisfactory economic evaluations of guideline implementation strategies have been performed. Current evaluations have numerous methodological defects and rarely consider all relevant costs and benefits. Future evaluations should focus on evaluating the implementation of evidence based guidelines. Keywords: Cost-effectiveness analysis, physician (or health care professional) behaviour, practice guidelines, quality improvement, systematic review.Peer reviewedAuthor versio

An optimization principle for deriving nonequilibrium statistical models of Hamiltonian dynamics

A general method for deriving closed reduced models of Hamiltonian dynamical systems is developed using techniques from optimization and statistical estimation. As in standard projection operator methods, a set of resolved variables is selected to capture the slow, macroscopic behavior of the system, and the family of quasi-equilibrium probability densities on phase space corresponding to these resolved variables is employed as a statistical model. The macroscopic dynamics of the mean resolved variables is determined by optimizing over paths of these probability densities. Specifically, a cost function is introduced that quantifies the lack-of-fit of such paths to the underlying microscopic dynamics; it is an ensemble-averaged, squared-norm of the residual that results from submitting a path of trial densities to the Liouville equation. The evolution of the macrostate is estimated by minimizing the time integral of the cost function. The value function for this optimization satisfies the associated Hamilton-Jacobi equation, and it determines the optimal relation between the statistical parameters and the irreversible fluxes of the resolved variables, thereby closing the reduced dynamics. The resulting equations for the macroscopic variables have the generic form of governing equations for nonequilibrium thermodynamics, and they furnish a rational extension of the classical equations of linear irreversible thermodynamics beyond the near-equilibrium regime. In particular, the value function is a thermodynamic potential that extends the classical dissipation function and supplies the nonlinear relation between thermodynamics forces and fluxes

Genomic landscape of drug response reveals novel mediators of anthelmintic resistance

Like other pathogens, parasitic helminths can rapidly evolve resistance to drug treatment. Understanding the genetic basis of anthelmintic drug resistance in parasitic nematodes is key to tracking its spread and improving the efficacy and sustainability of parasite control. Here, we use an in vivo genetic cross between drug-susceptible and multi-drug-resistant strains of Haemonchus contortus in a natural host-parasite system to simultaneously map resistance loci for the three major classes of anthelmintics. This approach identifies new alleles for resistance to benzimidazoles and levamisole and implicates the transcription factor cky-1 in ivermectin resistance. This gene is within a locus under selection in ivermectin-resistant populations worldwide; expression analyses and functional validation using knockdown experiments support that cky-1 is associated with ivermectin survival. Our work demonstrates the feasibility of high-resolution forward genetics in a parasitic nematode and identifies variants for the development of molecular diagnostics to combat drug resistance in the field

Patterns of Failure after IMRT in Head and Neck Squamous Cell Carcinoma of Unknown Primary: Implication of Elective Nodal and Mucosal Dose Coverage

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Trackly:A Customisable and Pictorial Self-Tracking App to Support Agency in Multiple Sclerosis Self-Care

Self-tracking is an important part of self-care. However, predefined self-tracking approaches can impede people's agency in managing their health. We investigated a customisable and pictorial self-tracking approach in multiple sclerosis self-management by implementing and conducting a field study of Trackly: a prototype app that supports people in defining and colouring pictorial trackers, such as body shapes. We found that participants utilised the elements of Trackly designed to support agentive behaviour: they defined personally meaningful tracking parameters in their own words, and particularly valued being able to flexibly colour in and make sense of their pictorial trackers. Having been able to support their individual self-care intentions with Trackly, participants reported a spectrum of interrelated experiences of agency, including a sense of ownership, identity, self-awareness, mindfulness, and control. Our findings demonstrate the importance of supporting people's individual needs and creative capacities to foster mindful and personally meaningful engagement with health and wellbeing data