30 research outputs found
Structure Effect on Antioxidant Activity of Catecholamines toward Singlet Oxygen and Other Reactive Oxygen Species in vitro
The reactivity of catecholamine neurotransmitters and the related metabolites were precisely investigated toward 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and reactive oxygen species. Catecholamines reacted immediately with DPPH radicals, their reactivity being stronger than that of ascorbic acid as a reference. Superoxide scavenging activities of catecholamines determined by WST-1 and electron spin resonance (ESR) spin trapping methods were also high. Whereas tyrosine, the dopamine precursor showed no reactivity toward superoxide. The reactivity toward singlet oxygen was evaluated by observing specific photon emission from singlet oxygen. The results revealed that reactivity of catecholamines was markedly higher than that of sodium azide, and catechin as catechol reference. The reaction of catecholamines and singlet oxygen was further studied by ESR using 55-dimethyl-1-pyrroline N-oxide (DMPO) as a spin trapping reagent and rose bengal as photosensitizer. DMPO-OH signal of epinephrine was significantly small compared to other catecholamines, catechin, and 4-methylcatechol as a reference compound and was as small as that of tyrosine. The signal formation was totally dependent on singlet oxygen, and the presence of catechol compounds. These results indicated that epinephrine is the most potent singlet oxygen quencher than other catecholamines, and the secondary amino group in its alkyl side chain could play a role in unique singlet oxygen quenching property of epinephrine
Synthesis of Various Cationic Ruthenium−Aqua Complexes with Hydrotris(3,5-diisopropylpyrazolyl)borate Ligand, Tp i
Two Isomeric Structures of Hydridoruthenium Complexes Supported by Hydrotrispyrazolylborates, Tp R
Synthesis and Dehydrative Condensation of Monomeric Hydroxoruthenium Complexes with Hydrotris(3,5-diisopropylpyrazolyl)borate Ligand, Tp i
Why do (R,R)- and (R,S)-(salen)manganese(III) complexes show different substrate-specificity? the role of an apical aqua ligand
The structure of (R,R)-(salen)manganese(III) complex (2) possessing axial chirality as a chiral element was determined unambiguously by X-ray analysis. The central manganese ion of 2 is coordinated by two aqua ligands at the apical sites. The attractive interaction between the aqua ligand and the 2'-phenyl group in the C3-naphthyl substituent affects the ligand conformation and, in turn, influences the asymmetric induction by 2