Simultaneous estimation of complementary moment independent and reliability-oriented sensitivity measures

International audienceIn rare event analysis, the estimation of the failure probability is a crucial objective. However, focusing only on the occurrence of the failure event may be insufficient to entirely characterize the reliability of the considered system. This paper provides a common estimation scheme of two complementary moment independent sensitivity measures, allowing to improve the understanding of the system’s rare event. Numerical applications are performed in order to show the effectiveness of the proposed estimation procedure

Estimation of moment independent importance measures using a copula and maximum entropy framework

International audienceThe moment-independent sensitivity analysis technique introduced by E. Borgonovo has gained increasing attention to characterize the uncertainty of complex systems and optimize their reliability. The estimation of corresponding indices is a challenging task. This paper aims at presenting a new estimation scheme valid for dependent model inputs. This scheme is build on the copula representation of indices and uses maximum entropy methods to estimate this copula. Accuracy of the proposed method is evaluated through numerical simulations and is compared to two competitive methods, namely an importance sampling based approach and a second one which uses the Nataf transformation

A nonparametric importance sampling estimator for moment independent importance measures

International audienceMoment independent importance measures have been proposed by E. Borgonovo [1] in order to alleviate some of the drawbacks of variance-based sensibility indices. They have gained increasing attention over the last years but their estimation remains a challenging issue. An effective estimation scheme in the case of correlated inputs, referred to as single-loop method, has been proposed by Wei et al. [2]. In this paper we show via simulation that this method may be inaccurate, making for instance 40% error in the simplest possible Gaussian case. We then propose a new estimation scheme which greatly improves the accuracy of the single-loop method, up to a factor 10 in some simple numerical examples. We prove that our estimator is strongly consistent and several simulation results are presented to demonstrate the advantages of the proposed method

Improvement of the cross-entropy method in high dimension for failure probability estimation through a one-dimensional projection without gradient estimation

Rare event probability estimation is an important topic in reliability analysis. Stochastic methods, such as importance sampling, have been developed to estimate such probabilities but they often fail in high dimension. In this paper, we propose a new cross-entropy-based importance sampling algorithm to improve rare event probability estimation in high dimension. We focus on the cross-entropy method with Gaussian auxiliary distributions and we suggest to update the Gaussian covariance matrix only in a one-dimensional subspace. For that purpose, the main idea is to consider the projection in the one-dimensional subspace spanned by the sample mean vector, which gives an influential direction for the variance estimation. This approach does not require any additional simulation budget compared to the basic cross-entropy algorithm and we show on different numerical test cases that it greatly improves its performance in high dimension

SOTA OPTICAL DOWNLINKS TO DLR’S OPTICAL GROUND STATIONS

Optical Satellite Downlinks have gathered increasing attention in the last years. A number of experimental payloads have become available, and downlink experiments are conducted around the globe. One of these experimental systems is SOTA, the Small Optical Transponder, built by the National Institute of Information and Communications Technology (NICT). This paper describes the downlink experiments carried out from SOTA to the German Aerospace Center’s Optical Ground Stations located in Oberpfaffenhofen, Germany. Both the Transportable Optical Ground Station (TOGS) as well as the fixed Optical Ground Station Oberpfaffenhofen (OGS-OP) are used for the experiments. This paper will explain the preparatory work, the execution of the campaign, as well as show the first results of the measurements

Modeling of piezoelectric actuator's hysteresis and its effect on the control accuracy of a LEO-to-GEO laser-communication for a small satellite

Compared to conventional large satellites in the past, small satellite classes (less than 150 kg) show their advantages for mass production, such as short time and low cost for development and launch, to cope with the demand for emerging missions that require a sufficient number of satellites in orbit. However, the traditional communication method, in which a low earth orbit (LEO) small satellite sends data to a ground station using radio frequency, has several disadvantages. Firstly, the limitation of radio-frequency bandwidth leads to a low data rate and difficulty in getting a frequency license. Secondly, there is a significant delay during which data cannot be sent to the ground due to lacking a line of sight between the LEO satellite and the ground station. Additionally, the duration time for the small satellite to communicate with the ground station is just less than 10 minutes approximately. To resolve the above issues, we investigate the case that a less-than-150-kg satellite carries out a laser communication link from LEO to a satellite in geostationary orbit (GEO). Due to the constraints of size, weight, and power (SWaP), traditional bulky LEO-GEO relay systems cannot be applied for the small satellite. However, using the combination of the satellite body pointing and a piezo Fast-Steering Mirror (FSM), which reduces the SWaP considerably, makes it feasible that the LEO-to-GEO communication can be implemented in a small satellite for the first time. While utilizing laser communication can increase the data rate, the relay communication via the GEO satellite helps the small satellite to extend the communication duration significantly. Moreover, since there is a line of sight between the two terminals in any of about 15 orbits per day of the LEO satellite, data taken by the small satellite can be downloaded to the ground via the GEO one in almost real time. This research aims at investigating and proving the feasibility of a small satellite to transmit a laser communication link to its GEO counterpart. In this paper, we describe the LEO-to-GEO laser communication of the small satellite with a study of pointing-budget and link-budget analysis. Furthermore, a hardware-based simulation of the fine control mechanism is conducted. The hysteresis that affects severely to the piezo mechanism, and hence, the final control accuracy, is modeled accurately and its effect is shown

Impact of TOTUM-63, a fibre and polyphenol rich plant-based composition, on gut and pancreatic hormone secretion in diet-induced obese mice

International audienceBackground and AimsTOTUM-63, a fibre and polyphenol rich plant-based composition, has been demonstrated to significantly improve body weight and glucose homeostasis in animal models of obesity. Our study aimed at exploring whether the mechanisms include modulation of gut (glucose-dependent insulinotropic peptide (GIP), glucagon-like petide-1 (GLP-1), cholecystokinin (CCK), peptide YY (PYY)) and pancreatic (insulin, glucagon) hormones, all important regulators of glucose control, appetite and body weight.Methods and ResultsMale C57BL/6JRJ mice were assigned to either standard chow (CON), high fat diet (HF, 60% energy from fat) or HF-TOTUM-63 (HF diet 60% supplemented with TOTUM-63 2.7%) for 10 weeks. In vivo glucose homeostasis (oral glucose tolerance test (OGTT), intraperitoneal pyruvate tolerance test (ipPTT)), glucose-induced portal vein hormone concentration, gut hormone gene expression and protein content as well as enteroendocrine cell contents were assessed at the end of the dietary intervention. The present study evidenced that TOTUM-63 reduced food intake, limited weight gain and improved glucose and pyruvate tolerance of HF-fed animals. This was associated with an increase in PYY content in the colon, an altered pattern of PYY secretion between fasted and glucose-stimulated states, and with a significant improvement in the portal vein concentration of GLP-1, insulin and glucagon, but not GIP and CCK, in response to glucose stimulation.ConclusionOverall, these data suggest that TOTUM-63 might have a specific impact on gut L-cells and on the expression and secretion of GLP-1 and PYY incretins, potentially contributing to the reduced food intake, body weight gain and improved glucose homeostasis

The Novodiag® Stool parasites assay, an innovative high-plex technique for fast detection of protozoa, helminths and microsporidia in stool samples: a retrospective and prospective study

International audienceObjectives: We provide the first evaluation of the CE-IVD marked Novodiag® stool parasites assay (NVD), allowing rapid and high-plex detection of 26 distinct targets, encompassing protozoans, helminths and microsporidia in stool samples. Methods: A total of 254 samples (n = 205 patients) were prospectively processed by the NVD and our routine procedure (RP). Performances of the NVD were compared with RP. Samples only positive by the NVD assay were investigated by external PCR assays. Sensitivity and specificity (Se/Sp) and time from sample receipt to results were determined for each method. The NVD was also evaluated against 77 additional samples positive for a wide range of parasites. Results: Overall positivity rate was 16.9% for RP compared with 34% using the NVD assay, and 164 samples (66%) were negative by both methods. Only 30 positive samples (12%) showed full concordance between RP and NVD. Fifty-three discordant samples were sent for external investigations. Except for Giardia intestinalis and Trichuris spp., higher Se was observed for the NVD assay for Blastocystis spp. (100% vs. 63%), Dientamoeba fragilis (100% vs. 0%), Schistosoma spp. (100% vs. 17%), and Enterobius vermicularis (100% vs. 67%) but roughly similar to RP for the remaining parasites tested. False-positive results were identified for Blastocystis spp., G. intestinalis, and Trichuris spp. using the NVD assay. The NVD mostly provides a diagnosis on the day of sample receipt compared with a mean of three days with RP. Conclusions: Besides some limitations, the NVD is a new diagnostic strategy allowing rapid and high-plex detection of gastrointestinal parasites from unpreserved stools