5 research outputs found
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the two most common non-Hodgkin lymphomas (NHLs). Here we sequenced tumour and matched normal DNA from 13 DLBCL cases and one FL case to identify genes with mutations in B-cell NHL. We analysed RNA-seq data from these and another 113 NHLs to identify genes with candidate mutations, and then re-sequenced tumour and matched normal DNA from these cases to confirm 109 genes with multiple somatic mutations. Genes with roles in histone modification were frequent targets of somatic mutation. For example, 32% of DLBCL and 89% of FL cases had somatic mutations in MLL2, which encodes a histone methyltransferase, and 11.4% and 13.4% of DLBCL and FL cases, respectively, had mutations in MEF2B, a calcium-regulated gene that cooperates with CREBBP and EP300 in acetylating histones. Our analysis suggests a previously unappreciated disruption of chromatin biology in lymphomagenesis
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Issues of Interpersonal Bonds
In this work, sections of bodies are joined with sections of other people's bodies in order to form a new whole. Adding or subtracting relationships can many times be uncomfortable and strange, which I depict in my invented individuals based on the phases of family, such as birth, death, marriage, divorce, and the acquisition of new forms of family. This work questions issues of the family in terms of its definition, whether biologically or culturally constructed. I am creating hybrids by separating body parts from the whole and then recombining them to form a new individual. These images are a result of thinking about the possibilities and changes that people go through as a result of the new growth or loss of relationships. This work is intended to bring awareness to the way in which people relate and families become more blended
Self-Portrait in Autumn
Originally featured in the 2023 edition of Forces.https://digitalcommons.collin.edu/forcesexhibition2023/1016/thumbnail.jp