Overheating in Scotland: contributing factors in occupied homes

There is growing awareness of the overheating risks in new-build properties in the UK. However, this tends to be considered a problem principally for the southern regions in the UK, only becoming a serious issue in the north of England in the medium-term and in the long-term for Scotland. This notion tends to be largely predicated upon climate change predictions, differences in latitude and summer air temperatures. This paper describes the results from Building Performance Evaluation (BPE) studies over a two-year period from 26 occupied new-build homes across Scotland which demonstrated incidences of overheating. Results suggest that low-energy buildings are susceptible to overheating despite northerly latitudes, with 54% of houses studied overheating for more than six months annually, and 27% of homes overheating for less than 10% of the year. Evidence indicated that commonly used prediction tools do not appear to anticipate overheating adequately. This paper maps common overheating causes due to design and the role of occupants, identifying the risks due to the regulatory system, prediction and procurement processes, and design and construction. A common finding was that design and occupancy factors appear to have a greater impact on overheating more than location and climatic factors

Phase I dose-escalation and pharmacokinetic study of dasatinib in patients with advanced solid tumors

PURPOSE: To determine the maximum tolerated dose, dose-limiting toxicity (DLT), and recommended phase II dose of dasatinib in metastatic solid tumors refractory to standard therapies or for which no effective standard therapy exists. <br></br> EXPERIMENTAL DESIGN: In this phase I, open-label, dose-escalation study, patients received 35 to 160 mg of dasatinib twice daily in 28-day cycles either every 12 hours for 5 consecutive days followed by 2 nontreatment days every week (5D2) or as continuous, twice-daily (CDD) dosing. <br></br> RESULTS: Sixty-seven patients were treated (5D2, n = 33; CDD, n = 34). The maximum tolerated doses were 120 mg twice daily 5D2 and 70 mg twice daily CDD. DLTs with 160 mg 5D2 were recurrent grade 2 rash, grade 3 lethargy, and one patient with both grade 3 prolonged bleeding time and grade 3 hypocalcemia; DLTs with 120 mg twice daily CDD were grade 3 nausea, grade 3 fatigue, and one patient with both grade 3 rash and grade 2 proteinuria. The most frequent treatment-related toxicities across all doses were nausea, fatigue, lethargy, anorexia, proteinuria, and diarrhea, with infrequent hematologic toxicities. Pharmacokinetic data indicated rapid absorption, dose proportionality, and lack of drug accumulation. Although no objective tumor responses were seen, durable stable disease was observed in 16% of patients.<br></br> CONCLUSION: Dasatinib was well tolerated in this population, with a safety profile similar to that observed previously in leukemia patients, although with much less hematologic toxicity. Limited, although encouraging, preliminary evidence of clinical activity was observed. Doses of 120 mg twice daily (5D2) or 70 mg twice daily (CDD) are recommended for further studies in patients with solid tumors.<br></br&gt

The incorporation of fungal to bacterial ratios and plant ecosystem effect traits into a state-and-transition model of land-use change in semi-arid grasslands

Feedbacks between plants, microbes and their growth traits are important in the maintenance of nutrient cycling functions. Despite this, there is little understanding of the role of these relationships in the transitions between alternate vegetation states in semi-arid and arid lands. We investigated the relationships between vegetation, soil nutrients and soil microbes across grasslands and agricultural fields described within an existing conceptual state-and-transition model of agricultural de-intensification in the semi-arid Riverine Plains grasslands of south-eastern Australia. Sites represented the proposed transition from annual exotic pastures to native perennial grasslands with agricultural de-intensification. Microbial community composition was assessed using phospholipid fatty acid analysis (PLFA). The native grassland state and the native pasture state were characterized by a higher fungal to bacterial ratio (F:B). The native grassland state had a slightly lower bacterial PLFA biomass whilst the native pasture state had a slightly higher fungal PLFA biomass, although these differences were non-significant. Only the recently cultivated, heavily grazed state was characterized by high soil nutrient availability (soil P and K) and leaf traits indicating rapid growth and resource utilization (high SLA, low LDMC). Thus, the association of these ecosystem properties with a lower F:B was not as close as expected. States with a higher F:B were not characterized by higher total soil C or C:N as hypothesized. This study further extends our knowledge of the association between fungal dominance and agricultural de-intensification to a semi-arid system with relatively old, nutrient poor soils. It highlights the need for a better understanding of the mechanistics behind this association and the implications for C cycling and storage in such systems.Megan R. Wong, John W. Morgan, Nathan K. Wong, Timothy R. Cavagnar

Nematic Films and Radially Anisotropic Delaunay Surfaces

We develop a theory of axisymmetric surfaces minimizing a combination of surface tension and nematic elastic energies which may be suitable for describing simple film and bubble shapes. As a function of the elastic constant and the applied tension on the bubbles, we find the analogues of the unduloid, sphere, and nodoid in addition to other new surfaces.Comment: 15 pages, 18 figure

The Race Between Stars and Quasars in Reionizing Cosmic Hydrogen

The cosmological background of ionizing radiation has been dominated by quasars once the Universe aged by ~2 billion years. At earlier times (redshifts z>3), the observed abundance of bright quasars declined sharply, implying that cosmic hydrogen was reionized by stars instead. Here, we explain the physical origin of the transition between the dominance of stars and quasars as a generic feature of structure formation in the concordance LCDM cosmology. At early times, the fraction of baryons in galaxies grows faster than the maximum (Eddington-limited) growth rate possible for quasars. As a result, quasars were not able to catch up with the rapid early growth of stellar mass in their host galaxies.Comment: 5 pages, 1 figure, Accepted for publication in JCA

A CsI(Tl) Scintillating Crystal Detector for the Studies of Low Energy Neutrino Interactions

Scintillating crystal detector may offer some potential advantages in the low-energy, low-background experiments. A 500 kg CsI(Tl) detector to be placed near the core of Nuclear Power Station II in Taiwan is being constructed for the studies of electron-neutrino scatterings and other keV-MeV range neutrino interactions. The motivations of this detector approach, the physics to be addressed, the basic experimental design, and the characteristic performance of prototype modules are described. The expected background channels and their experimental handles are discussed.Comment: 34 pages, 11 figures, submitted to Nucl. Instrum. Method

Deposition and solubility of airborne metals to four plant species grown at varying distances from two heavily trafficked roads in London

In urban areas, a highly variable mixture of pollutants is deposited as particulate matter. The concentration and bioavailability of individual pollutants within particles need to be characterised to ascertain the risks to ecological receptors. This study, carried out at two urban parks, measured the deposition and water-solubility of metals to four species common to UK urban areas. Foliar Cd, Cr, Cu, Fe, Ni, Pb and Zn concentrations were elevated in at least one species compared with those from a rural control site. Concentrations were, however, only affected by distance to road in nettle and, to a lesser extent, birch leaves. Greater concentrations of metal were observed in these species compared to cypress and maple possibly due to differences in plant morphology and leaf surfaces. Solubility appeared to be linked to the size fraction and, therefore, origin of the metal with those present predominantly in the coarse fraction exhibiting low solubility. © 2009

Search for displaced vertices arising from decays of new heavy particles in 7 TeV pp collisions at ATLAS

We present the results of a search for new, heavy particles that decay at a significant distance from their production point into a final state containing charged hadrons in association with a high-momentum muon. The search is conducted in a pp-collision data sample with a center-of-mass energy of 7 TeV and an integrated luminosity of 33 pb^-1 collected in 2010 by the ATLAS detector operating at the Large Hadron Collider. Production of such particles is expected in various scenarios of physics beyond the standard model. We observe no signal and place limits on the production cross-section of supersymmetric particles in an R-parity-violating scenario as a function of the neutralino lifetime. Limits are presented for different squark and neutralino masses, enabling extension of the limits to a variety of other models.Comment: 8 pages plus author list (20 pages total), 8 figures, 1 table, final version to appear in Physics Letters

Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment

This paper describes an analysis of the angular distribution of W->enu and W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector at the LHC in 2010, corresponding to an integrated luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and the missing transverse energy, the W decay angular distribution projected onto the transverse plane is obtained and analysed in terms of helicity fractions f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw > 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour, are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017 +/- 0.030, where the first uncertainties are statistical, and the second include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables, revised author list, matches European Journal of Physics C versio