An Improved Earthquake Catalog During the 2018 Kı̄lauea Eruption From Combined Onshore and Offshore Seismic Arrays

The Island of Hawai’i was formed by repeated eruptions of basalts at an oceanic hotspot. Kı̄lauea, the youngest among the subaerial volcanoes of the island, erupted intensely in 2018. The eruption provided an opportunity to look into the mechanisms that operate at the volcano and associated earthquake activities, as it was recorded simultaneously, for the first time, by onshore and offshore seismometers. We used most of the publicly available seismic data during the eruption period, including temporary arrays, to build a more complete earthquake catalog during the eruption than that provided by the Hawaiian Volcano Observatory. We used a short-time-average/long-time-average method to identify potential earthquakes. The detections were associated with events and automatically picked with P-wave and S-wave arrivals, which were used to locate the events in a three-dimensional velocity model. After re-examining these earthquake events, their coda/duration magnitudes were determined. The resulting half-year catalog contains 375,736 events with one of the highest daily earthquake numbers ever reported (6,128 on 21 June 2018). A great number of events were recorded during the caldera collapses, from its beginning until its rapid ending. The catalog also contains abundant events near the Pu’u‘ō‘ō vent and in the lower East Rift Zone, where an increase of seismicity in mid-July and August indicated a step-up in magma intrusion after the eruption

Low-excitation blobs in the Magellanic Clouds

Aims : We study an unknown, or very poorly known, interstellar HII component in the Magellanic Clouds. This is the first study ever devoted to this class of objects, which we call Low-excitation blobs (LEBs). Methods : We used low-dispersion spectroscopy carried out at ESO to obtain emission line intensities of Ha, Hb, and [OIII] (4959+5007) for 15 objects in the Large Magellanic Cloud and 14 objects in the Small Magellanic Cloud. Results are displayed in excitation ([oiii]/Hb ratio) versus Hb luminosity diagrams. Results : We show the presence of an LEB component in the Magellanic Clouds and study its relationship with the already known class of high-excitation blobs (HEBs). The newly found LEBs are lower excitation counterparts of HEBs and are powered by less massive exciting stars. Further study of LEBs is expected to provide new pieces of information for a better understanding the low mass end of the upper initial mass function in the Magellanic Clouds.Comment: Accepted in A&

Comparison of outcomes using the rituximab originator MabThera with the biosimilar Truxima in patients with ANCA-associated vasculitis

Objectives: The use of rituximab (MabThera®), an anti-CD20 monoclonal antibody, is the most significant development in the management of anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) since the introduction of cytotoxic therapy in 1950. Truxima® is the first anti-CD20 biosimilar approved for the same indications, and has been available in the UK since 2017. Significant cost savings have been reported when switching to biosimilars, which could lead to greater patient access to such treatment. Therefore, it is important to know whether patients’ clinical and laboratory parameters respond equally well to biosimilars as to reference medicines, tested in clinical trials. Method: We retrospectively reviewed the clinical outcomes and laboratory parameters in 257 consecutive patients treated with anti-CD20 depletion therapy using MabThera or Truxima, for induction and maintenance of remission, in two tertiary renal centres between 2010 and 2019. Results: We demonstrated no difference between patients treated with MabThera or Truxima in rates of remission, relapse, and hospitalization with infection when used for either induction or maintenance of remission of AAV. In one hospital subgroup analysis, we showed comparable levels of hypogammaglobulinaemia, B-cell depletion, and frequency of infusion reactions, with no significant differences. Conclusion: The efficacy and safety of the rituximab biosimilar Truxima are not inferior to the originator MabThera in patients with AAV. Truxima represents a cheaper and safe therapeutic alternative that could increase patient access to rituximab

The holistic phase model of early adult crisis

The objective of the current study was to explore the structural, temporal and experiential manifestations of crisis episodes in early adulthood, using a holistic-systemic theoretical framework. Based on an analysis of 50 interviews with individuals about a crisis episode between the ages of 25 and 35, a holistic model was developed. The model comprises four phases: (1) Locked-in, (2) Separation/Time-out, (3) Exploration and (4) Rebuilding, which in turn have characteristic features at four levels—person-in-environment, identity, motivation and affect-cognition. A crisis starts out with a commitment at work or home that has been made but is no longer desired, and this is followed by an emotionally volatile period of change as that commitment is terminated. The positive trajectory of crisis involves movement through an exploratory period towards active rebuilding of a new commitment, but ‘fast-forward’ and ‘relapse’ loops can interrupt Phases 3 and 4 and make a positive resolution of the episode less likely. The model shows conceptual links with life stage theories of emerging adulthood and early adulthood, and it extends current understandings of the transitional developmental challenges that young adults encounter

Triggered massive-star formation on the borders of Galactic HII regions. I. A search for `collect and collapse' candidates

Young massive stars or clusters are often observed at the peripheries of HII regions. What triggers star formation at such locations? Among the scenarios that have been proposed, the `collect and collapse' process is particularly attractive because it permits the formation of massive objects via the fragmentation of the dense shocked layer of neutral gas surrounding the expanding ionized zone. However, until our recent article on Sh 104, it had not been convincingly demonstrated that this process actually takes place. In the present paper we present our selection of seventeen candidate regions for this process; all show high-luminosity near-IR clusters and/or mid-IR point sources at their peripheries. The reality of a `collect and collapse' origin of these presumably second-generation stars and clusters will be discussed in forthcoming papers, using new near-IR and millimetre observations.Comment: To be published in A&

Nanosatellite optical downlink experiment: design, simulation, and prototyping

The nanosatellite optical downlink experiment (NODE) implements a free-space optical communications (lasercom) capability on a CubeSat platform that can support low earth orbit (LEO) to ground downlink rates>10  Mbps. A primary goal of NODE is to leverage commercially available technologies to provide a scalable and cost-effective alternative to radio-frequency-based communications. The NODE transmitter uses a 200-mW 1550-nm master-oscillator power-amplifier design using power-efficient M-ary pulse position modulation. To facilitate pointing the 0.12-deg downlink beam, NODE augments spacecraft body pointing with a microelectromechanical fast steering mirror (FSM) and uses an 850-nm uplink beacon to an onboard CCD camera. The 30-cm aperture ground telescope uses an infrared camera and FSM for tracking to an avalanche photodiode detector-based receiver. Here, we describe our approach to transition prototype transmitter and receiver designs to a full end-to-end CubeSat-scale system. This includes link budget refinement, drive electronics miniaturization, packaging reduction, improvements to pointing and attitude estimation, implementation of modulation, coding, and interleaving, and ground station receiver design. We capture trades and technology development needs and outline plans for integrated system ground testing.United States. National Aeronautics and Space Administration. Research Fellowship ProgramLincoln Laboratory (Lincoln Scholars)Lincoln Laboratory (Military Fellowship Program)Fundación Obra Social de La Caixa (Fellowship)Samsung FellowshipUnited States. Air Force (Assistant Secretary of Defense for Research & Engineering. Contract FAs872105C0002

Family food practices: relationships, materiality and the everyday at the end of life

This article draws on data from a research project that combined participant observation with in-depth interviews to explore family relationships and experiences of everyday life during life-threatening illness. In it I suggest that death has often been theorised in ways that make its ‘mundane’ practices less discernible. As a means to foreground the everyday, and to demonstrate its importance to the study of dying, this article explores the (re)negotiation of food and eating in families facing the end of life. Three themes that emerged from the study’s broader focus on family life are discussed: ‘food talk’ and making sense of illness; food, family and identity; and food ‘fights’. Together the findings illustrate the material, social and symbolic ways in which food acts relationally in the context of dying, extending conceptual work on materiality in death studies in novel directions. The paper also contributes new empirical insights to a limited sociological literature on food, families and terminal illness, building on work that theorises the entanglements of materiality, food, bodies and care. The article concludes by highlighting the analytical value of everyday materialities such as food practices for future research on dying as a relational experience

Bureaucracy as a Lens for Analyzing and Designing Algorithmic Systems

Scholarship on algorithms has drawn on the analogy between algorithmic systems and bureaucracies to diagnose shortcomings in algorithmic decision-making. We extend the analogy further by drawing on Michel Crozier’s theory of bureaucratic organizations to analyze the relationship between algorithmic and human decision-making power. We present algorithms as analogous to impartial bureaucratic rules for controlling action, and argue that discretionary decision-making power in algorithmic systems accumulates at locations where uncertainty about the operation of algorithms persists. This key point of our essay connects with Alkhatib and Bernstein’s theory of ’street-level algorithms’, and highlights that the role of human discretion in algorithmic systems is to accommodate uncertain situations which inflexible algorithms cannot handle. We conclude by discussing how the analysis and design of algorithmic systems could seek to identify and cultivate important sources of uncertainty, to enable the human discretionary work that enhances systemic resilience in the face of algorithmic errors.Peer reviewe