2 research outputs found
Back to the Drawing Board: A Treatment Program for Nonverbal Aphasic Patients
- Publication venue
- BRK Publishers
- Publication date
- 01/01/1987
- Field of study
Get PDFTB
Rare and low-frequency coding variants alter human adult height
- Author
- Abecasis G.R. (Gonçalo)
- Aben K.K.H. (Katja)
- Adair L.S. (Linda)
- Alam D.S. (Dewan S.)
- Albrecht E. (Eva)
- Allin K.H. (Kristine H)
- Allison M.A. (Matthew)
- Amouyel P. (Philippe)
- Angelantonio E. (Emanuele) di
- Appel E.V. (Emil V.)
- Arveiler D. (Dominique)
- Asselbergs F.W. (Folkert)
- Auer P. (Paul)
- Bakker P.I.W. (Paul) de
- Balkau B. (Beverley)
- Banas B. (Bernhard)
- Bang L.E. (Lia E.)
- Benn M. (Marianne)
- Bergmann S. (Sven)
- Bielak L.F. (Lawrence F.)
- Blüher M. (Matthias)
- Boehnke M. (Michael)
- Boeing H. (Heiner)
- Boerwinkle E.A. (Eric)
- Bonnycastle L.L. (Lori)
- Borecki I.B. (Ingrid)
- Bork-Jensen J. (Jette)
- Borst G.J. (Gert) de
- Bots M.L. (Michiel)
- Bottinger E.P. (Erwin)
- Bowden D.W. (Donald)
- Brandslund I. (Ivan)
- Breen G. (Gerome)
- Brilliant M.H. (Murray H.)
- Broer L. (Linda)
- Burt A.D. (Alastair)
- Butterworth A.S. (Adam)
- Böger C.A. (Carsten)
- Carey D.J. (David J.)
- Caulfield M. (Mark)
- Chambers J.C. (John)
- Chasman D.I. (Daniel)
- Chen Y.-D.I. (Yii-Der Ida)
- Chowdhury R. (Rajiv)
- Christensen C. (Cramer)
- Chu A.Y. (Audrey)
- Cocca M. (Massimiliano)
- Collins F.S. (Francis)
- Cook J.P. (James P.)
- Corley J. (Janie)
- Cox A.J. (Amanda J.)
- Cuellar-Partida G. (Gabriel)
- Danesh J. (John)
- Davies G. (Gail)
- De Denus S. (Simon)
- De Groot M.C.H. (Mark C.H.)
- Deary I.J. (Ian)
- Dedoussis G.V. (George)
- Deloukas P. (Panos)
- Demerath E.W. (Ellen)
- Dennis J. (Joe)
- Drenos F. (Fotios)
- Du M. (Mengmeng)
- Duijn C.M. (Cornelia) van
- Dunning A.M. (Alison M.)
- Easton D.F. (Douglas)
- Ebeling T. (Tapani)
- Edwards T.L. (Todd L.)
- Ellinor P.T. (Patrick)
- Elliott P. (Paul)
- Esko T. (Tõnu)
- Evangelou E. (Evangelos)
- Farmaki A.-E. (Aliki-Eleni)
- Faul J.D. (Jessica D.)
- Feitosa M.F. (Mary Furlan)
- Feng S. (Shuang)
- Ferrannini E. (Ele)
- Ferrario M.M. (Marco M.)
- Ferrieres J. (Jean)
- Fine R.S. (Rebecca S.)
- Florez J.C. (Jose)
- Ford I.
- Fornage M. (Myriam)
- Franks P.W. (Paul)
- Frayling T.M. (Timothy)
- Frikke-Schmidt R. (Ruth)
- Galbany J.C. (Jordi Corominas)
- Galesloot T.E. (Tessel)
- Gan W. (Wei)
- Gandin I. (Ilaria)
- Gasparini P. (Paolo)
- Giedraitis V. (Vilmantas)
- Giri A. (Ayush)
- Girotto S.
- Gordon S.D. (Scott D.)
- Gordon-Larsen P. (Penny)
- Gorski M. (Mathias)
- Graff M.J. (Maud J.L.)
- Grarup N. (Niels)
- Grove M.L. (Megan)
- Gudnason V. (Vilmundur)
- Guo X. (Xiuqing)
- Gustafsson S. (Stefan)
- Hansen T. (T.)
- Harris K.M. (Kathleen Mullan)
- Harris T.B. (Tamara)
- Hart't L.M. (Leen M.)
- Hattersley A.T. (Andrew)
- Hayward C. (Caroline)
- He L. (Liang)
- Heard-Costa N.L. (Nancy)
- Heid I.M. (Iris)
- Heikkilä K. (Kauko)
- Helgeland Ø. (Øyvind)
- Hernesniemi J. (Jussi)
- Hewit A.W. (Alex)
- Highland H. (Heather)
- Hirschhorn J.N. (Joel)
- Hocking L.J. (Lynne)
- Hollander A.I. (Anneke)
- Hollensted M. (Mette)
- Holmen O.L. (Oddgeir)
- Hovingh G.K. (Kees)
- Howson J.M.M. (Joanna M.M.)
- Hoyng C.B. (Carel)
- Huang P.L. (Paul L.)
- Hveem K. (Kristian)
- Ikram M.K. (Kamran)
- Ingelsson E. (Erik)
- Jackson A.U. (Anne)
- Jansson J.-H. (Jan-Håkan)
- Jarvik G.P. (Gail)
- Jensen G.B. (Gorm B.)
- Jhun M.A. (Min A.)
- Jia Y. (Yucheng)
- Jiang X. (Xuejuan)
- Johansson S. (Stefan)
- Jorgensen T. (Torben)
- Jousilahti P. (Pekka)
- Jukema J.W. (Jan Wouter)
- Justice A.E. (Anne)
- Jørgensen M.E. (Marit E.)
- Kahali B. (Bratati)
- Kahn R. (René)
- Kamstrup P.R. (Pia R.)
- Kanoni S. (Stavroula)
- Kao W.H.L. (Wen)
- Kaprio J. (Jaakko)
- Karaderi T. (Tugce)
- Karaleftheri M. (Maria)
- Kardia S.L.R. (Sharon L.R.)
- Karpe F. (Fredrik)
- Kathiresan S. (Sekar)
- Kee F. (Frank)
- Keeman J.N.
- Kiemeney L.A.L.M. (Bart)
- Kitajima H. (Hidetoshi)
- Kjaer T.R. (Troels R.)
- Kluivers K.B. (Kirsten B.)
- Kocher T.
- Komulainen P. (Pirjo)
- Kontto J. (Jukka)
- Kooner J.S. (Jaspal S.)
- Kooperberg C. (Charles)
- Kovacs P. (Peter)
- Kriebel J. (Jennifer)
- Kuivaniemi H. (Helena)
- Kutalik Z. (Zoltán)
- Kuusisto J. (Johanna)
- Kähönen M. (Mika)
- Küry S. (Sébastien)
- La Bianca M. (Martina)
- Laakso M. (Markku)
- Lakka T.A. (Timo)
- Lamparter D. (David)
- Lange E.M. (Ethan)
- Lange L.A. (Leslie)
- Langefeld C.D. (Carl)
- Langenberg C. (Claudia)
- Larson E.B. (Eric B.)
- Lee I.-T. (I-Te)
- Lehtimäki T. (Terho)
- Lettre G. (Guillaume)
- Lewis C.E. (Cora E.)
- Li H. (Huaixing)
- Li J. (Jin)
- Li-Gao R. (Ruifang)
- Lin H. (Honghuang)
- Lin L.-A. (Li-An)
- Lin X. (Xu)
- Lindgren C.M. (Cecilia M.)
- Lindström J. (Jaana)
- Linneberg A. (Allan)
- Liu D. (Dajiang)
- Liu Y. (Yeheng)
- Liu Y. (YongMei)
- Lo K.S.
- Locke A. (Adam)
- Loohuis L.M.O. (Loes M. Olde)
- Loos R.J.F. (Ruth)
- Lophatananon A. (Artitaya)
- Lu Y. (Yingchang)
- Luan J. (Jian'An)
- Lubitz S.A. (Steven)
- Lyytikäinen L.-P. (Leo-Pekka)
- Mackey D.A. (David A.)
- Madden P.A. (Pamela)
- Mahajan A. (Anubha)
- Manning A.K. (Alisa)
- Marenne G. (Gaëlle)
- Marouli E. (Eirini)
- Marten J. (Jonathan)
- Martin N.G. (Nicholas)
- Masca N.G.D. (Nicholas G.D.)
- Mazul A.L. (Angela L.)
- McCarthy M.I. (Mark I.)
- Medina-Gomez C. (Carolina)
- Meidtner K. (Karina)
- Metspalu A. (Andres)
- Mitchell P. (Paul)
- Mohlke K.L. (Karen)
- Mook-Kanamori D.O. (Dennis)
- Morgan A. (Anna)
- Morris A.D. (Andrew D.)
- Morris A.P. (Andrew)
- Mudgal P. (Poorva)
- Munroe P. (Patricia)
- Mutsert R. (Reneé) de
- Männistö S. (Satu)
- Müller-Nurasyid M. (Martina)
- Nalls M.A. (Michael)
- Nauck M. (Matthias)
- Nelson C.P. (Christopher P.)
- Neville M.J. (Matthew)
- Ng M.C.Y. (Maggie C.Y.)
- Nielsen S.F. (Sune)
- Nikus K. (Kjell)
- Njolstad P. (Pal)
- Nordestgaard B.G. (Børge)
- North K.E. (Kari)
- Ntalla I. (Ioanna)
- O'Connel J.R. (Jeffrey R.)
- Oksa H. (Heikki)
- Ophoff R.A. (Roel)
- Owen K.R. (Katharine R.)
- Oxvig C. (Claus)
- Packard C.J. (Chris J.)
- Padmanabhan S. (Sandosh)
- Palmer C.N.A. (Colin)
- Pasterkamp G. (Gerard)
- Patel A.P. (Aniruddh)
- Pattie A. (Alison)
- Pedersen O. (Oluf)
- Peissig P.L. (Peggy L.)
- Peloso G.M. (Gina)
- Pennell C.E. (Craig)
- Perola M. (Markus)
- Perry J.A. (James A.)
- Perry J.R.B. (John R.B.)
- Pers T.H. (Tune)
- Person A.D. (Anthony)
- Pirie A. (Ailith)
- Polasek O. (Ozren)
- Posthuma D. (Danielle)
- Raitakari O.T. (Olli T.)
- Rasheed A. (Asif)
- Rauramaa R. (Rainer)
- Reilly D.F. (Dermot F.)
- Reiner A. (Alexander)
- Renström F. (Frida)
- Ridker P.M. (Paul)
- Rioux J.D. (John)
- Rivadeneira Ramirez F. (Fernando)
- Rivas M.A. (Manuel)
- Robertson N.R. (Neil)
- Robino A. (Antonietta)
- Rolandsson O. (Olov)
- Rotter J.I. (Jerome I.)
- Rudan I. (Igor)
- Ruth K.S. (Katherine S.)
- Rüeger S. (Sina)
- Saleheen D. (Danish)
- Salomaa V. (Veikko)
- Samani N.J. (Nilesh)
- Sandow K. (Kevin)
- Sapkota Y. (Yadav)
- Sattar N. (Naveed)
- Schmidt M.K. (Marjanka)
- Schoor N.M. (Natasja) van
- Schreiner P.J. (Pamela)
- Schulze M.B. (Matthias B)
- Schurmann C. (Claudia)
- Scott R.A. (Robert)
- Segura-Lepe M.P. (Marcelo P.)
- Setten J. (Jessica) van
- Shah S.H. (Svati)
- Sim X. (Xueling)
- Sivapalaratnam S. (Suthesh)
- Small K.S. (Kerrin)
- Smith A.V. (Albert Vernon)
- Smith J.A. (Jennifer A)
- Southam L. (Lorraine)
- Spector T.D. (Timothy)
- Speliotes E.K. (Elizabeth K.)
- Starr J.M. (John)
- Steinthorsdottir V. (Valgerdur)
- Stirrups K. (Kathy)
- Stringham H.M. (Heather)
- Stumvoll M. (Michael)
- Surendran P. (Praveen)
- Tansey K.E. (Katherine E.)
- Tardif J.-C. (Jean-Claude)
- Taylor K.D. (Kent)
- Teumer A. (Alexander)
- Thompson D. (Deborah)
- Thorleifsson G. (Gudmar)
- Thorsteinsdottir U. (Unnur)
- Thuesen B.H. (Betina H.)
- Tromp G. (Gerard)
- Trompet S. (Stella)
- Tsafantakis E. (Emmanouil)
- Tuomilehto J. (Jaakko)
- Turcot V. (Valérie)
- Tybjaerg-Hansen A. (Anne)
- Tyrer J.P. (Jonathan)
- Tönjes A. (Anke)
- Uher R.
- Uitterlinden A.G. (André)
- Ulivi S. (Sheila)
- Van Der Laan S.W. (Sander W.)
- Van Der Leij A.R. (Andries R.)
- Varbo A. (Anette)
- Varga T.V. (Tibor V.)
- Varma R. (Rohit)
- Vedantam S. (Sailaja)
- Velez Edwards D.R. (Digna R.)
- Vermeulen S.H.H.M. (Sita)
- Vestergaard H. (Henrik)
- Vitart V. (Veronique)
- Vogt T.F. (Thomas F.)
- Vozzi D. (Diego)
- Walker M. (Mark)
- Wang C.A. (Carol A.)
- Wang F. (Feijie)
- Wang S. (Shuai)
- Wang Y. (Yiqin)
- Wareham N.J. (Nicholas J.)
- Warren H. (Helen)
- Wessel J. (Jennifer)
- Willems S.M. (Sara)
- Willer C.J. (Cristen)
- Wilson J.F. (James)
- Winkler T.W. (Thomas W.)
- Witte D.R. (Deniel)
- Wood A.R. (Andrew)
- Woods M.O. (Michael)
- Wu Y. (Ying)
- Yaghootkar H. (Hanieh)
- Yao J. (Jiefen)
- Yao P. (Pang)
- Yerges-Armstrong L.M. (Laura)
- Young K.L. (Kristin L.)
- Young R. (Robin)
- Zeggini E. (Eleftheria)
- Zhan X. (Xiaowei)
- Zhang W. (Weihua)
- Zhao J.H. (Jing Hua)
- Zhao W. (Wei)
- Zheng H. (He)
- Zhou W. (Wei)
- Zwart J-A. (John-Anker)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 09/02/2017
- Field of study
No full textHeight is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height-increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of
