Thermal comfort evaluation in an educational building with air conditioning located in the warm tropical climate of Colombia

The objective of this work is to evaluate the perception of thermal comfort that students have in building 10 of the Universidad de la Costa located in the city of Barranquilla. For the investigation the methods for the thermal comfort evaluation are analyzed, selecting the Steady-State methodology of Fanger according to the ASHRAE 55 Standard. With the application of the surveys, the thermal sensation that the students had in the building was evaluated, which was preferably fresh and thermal acceptability where 87% responded satisfactorily to indoor climate conditions in classrooms. It was also obtained that the perception of inner thermal comfort is between 21.1 ° C and 23 ° C of temperature. With the results obtained, recommendations are issued to ensure that students feel thermal comfort and the proper regulation of air conditioning systems

Energy planning for fuel oil saving in an industrial laundry

In this paper was applied a method of energy planning, compatible with ISO 50001 standard, in an industrial laundry. In the analysis, three input variables were considered: level of production, technical condition of the system and operating regime. The past, present and future of fuel oil consumption in the steam generation and use was examined, establishing the causes of deterioration of consumption indicator. A study of load and capacity in the system identified potential savings through improved operating regime. A new regime for the operation of boilers was proposed and implemented, saving 16% of fuel. With the results of these measurements, the baseline was developed and goals are established.En el presente trabajo se diseña y aplica un procedimiento de planificación energética, compatible con la norma ISO 50001, a una lavandería industrial. Se analizan tres variables de entrada: nivel de producción, estado técnico del sistema y régimen de operación. Se examina el pasado, presente y futuro del consumo del fuel oíl en el sistema de generación y uso del vapor, estableciendo las causas del deterioro del indicador de consumo. A través de un estudio de carga y capacidad en el sistema se identificaron las potencialidades de ahorro mejorando el esquema de operación. Se propuso un nuevo esquema para la operación de las calderas el cual fue implementado lográndose un ahorro del 16% de combustible. Con los resultados de las mediciones se elabora la línea base y se establecen nuevas metas

Evaluación de la climatización en locales comerciales, integrando técnicas de termografía, simulación y modelado por elementos finitos

This study integrates different techniques to analyze some issues of the air conditioning system of a commercial establishment. A thermographic camera is used to assess the temperature profile in the area covered by the air conditioning system and also to detect the higher temperature spots. The air conditioning system of the facility is simulated using the software Trnsys to estimate the indoor temperature and the thermal load profile. Afterward, using computer-aided design, a model of the air circulation in the thermal zone is developed, which is simulated using the finite element method to obtain the temperature profile in the area. As a result, a new operational scheme of the air conditioning that improves the temperature profile is proposed

Mechanisms of Taxane Resistance

The taxane family of chemotherapy drugs has been used to treat a variety of mostly epithelial-derived tumors and remain the first-line treatment for some cancers. Despite the improved survival time and reduction of tumor size observed in some patients, many have no response to the drugs or develop resistance over time. Taxane resistance is multi-faceted and involves multiple pathways in proliferation, apoptosis, metabolism, and the transport of foreign substances. In this review, we dive deeper into hypothesized resistance mechanisms from research during the last decade, with a focus on the cancer types that use taxanes as first-line treatment but frequently develop resistance to them. Furthermore, we will discuss current clinical inhibitors and those yet to be approved that target key pathways or proteins and aim to reverse resistance in combination with taxanes or individually. Lastly, we will highlight taxane response biomarkers, specific genes with monitored expression and correlated with response to taxanes, mentioning those currently being used and those that should be adopted. The future directions of taxanes involve more personalized approaches to treatment by tailoring drug–inhibitor combinations or alternatives depending on levels of resistance biomarkers. We hope that this review will identify gaps in knowledge surrounding taxane resistance that future research or clinical trials can overcome

A personalized intervention to prevent depression in primary care: cost-effectiveness study nested into a clustered randomized trial

Background: Depression is viewed as a major and increasing public health issue, as it causes high distress in the people experiencing it and considerable financial costs to society. Efforts are being made to reduce this burden by preventing depression. A critical component of this strategy is the ability to assess the individual level and profile of risk for the development of major depression. This paper presents the cost-effectiveness of a personalized intervention based on the risk of developing depression carried out in primary care, compared with usual care. Methods: Cost-effectiveness analyses are nested within a multicentre, clustered, randomized controlled trial of a personalized intervention to prevent depression. The study was carried out in 70 primary care centres from seven cities in Spain. Two general practitioners (GPs) were randomly sampled from those prepared to participate in each centre (i.e. 140 GPs), and 3326 participants consented and were eligible to participate. The intervention included the GP communicating to the patient his/her individual risk for depression and personal risk factors and the construction by both GPs and patients of a psychosocial programme tailored to prevent depression. In addition, GPs carried out measures to activate and empower the patients, who also received a leaflet about preventing depression. GPs were trained in a 10- to 15-h workshop. Costs were measured from a societal and National Health care perspective. Qualityadjustedlife years were assessed using the EuroQOL five dimensions questionnaire. The time horizon was 18 months. Results: With a willingness-to-pay threshold of (sic)10, 000 ((sic)8568) the probability of cost-effectiveness oscillated from 83% (societal perspective) to 89% (health perspective). If the threshold was increased to (sic)30, 000 ((sic)25, 704), the probability of being considered cost-effective was 94% (societal perspective) and 96%, respectively (health perspective). The sensitivity analysis confirmed these results. Conclusions: Compared with usual care, an intervention based on personal predictors of risk of depression implemented by GPs is a cost-effective strategy to prevent depression. This type of personalized intervention in primary care should be further developed and evaluated

Designing a new science-policy communication mechanism for the UN Convention to Combat Desertification

The United Nations Convention to Combat Desertification (UNCCD) has lacked an efficient mechanism to access scientific knowledge since entering into force in 1996. In 2011 it decided to convene an Ad Hoc Working Group on Scientific Advice (AGSA) and gave it a unique challenge: to design a new mechanism for science-policy communication based on the best available scientific evidence. This paper outlines the innovative 'modular mechanism' which the AGSA proposed to the UNCCD in September 2013, and how it was designed. Framed by the boundary organization model, and an understanding of the emergence of a new multi-scalar and polycentric style of governing, the modular mechanism consists of three modules: a Science-Policy Interface (SPI); an international self-governing and self-organizing Independent Non-Governmental Group of Scientists; and Regional Science and Technology Hubs in each UNCCD region. Now that the UNCCD has established the SPI, it is up to the worldwide scientific community to take the lead in establishing the other two modules. Science-policy communication in other UN environmental conventions could benefit from three generic principles corresponding to the innovations in the three modules-joint management of science-policy interfaces by policy makers and scientists; the production of synthetic assessments of scientific knowledge by autonomous and accountable groups of scientists; and multi-scalar and multi-directional synthesis and reporting of knowledge

A Search for Photons with Energies Above 2 × 1017^{17} eV Using Hybrid Data from the Low-Energy Extensions of the Pierre Auger Observatory

Ultra-high-energy photons with energies exceeding 10$^{17}$ eV offer a wealth of connections to different aspects of cosmic-ray astrophysics as well as to gamma-ray and neutrino astronomy. The recent observations of photons with energies in the 10$^{15}$ eV range further motivate searches for even higher-energy photons. In this paper, we present a search for photons with energies exceeding 2 × 10$^{17}$ eV using about 5.5 yr of hybrid data from the low-energy extensions of the Pierre Auger Observatory. The upper limits on the integral photon flux derived here are the most stringent ones to date in the energy region between 10$^{17}$ and 10$^{18}$ eV