Absolute dimensions and apsidal motion of the eclipsing binaries V889 Aquilae and V402 Lacertae

Context. Double-lined eclipsing binaries allow the direct determination of masses and radii, which are key for testing stellar models. With the launch of the TESS mission, many well-known eclipsing binaries have been observed at higher photometric precision, permitting the improvement of the absolute dimension determinations. Aims. Using TESS data and newly obtained spectroscopic observations, we aim to determine the masses and radii of the eccentric eclipsing binary systems V889 Aql and V402 Lac, together with their apsidal motion parameters. Methods. We simultaneously modelled radial velocity curves and times of eclipse for each target to precisely determine the orbital parameters of the systems, which we used to analyse the light curves and then obtain their absolute dimensions. We compared the obtained values with those predicted by theoretical models. Results. We determined masses and radii of the components of both systems with relative uncertainties lower than 2%. V889 Aql is composed of two stars with masses 2:17±0:02 M⊙ and 2:13±0:01 M⊙ and radii 1:87±0:04 R⊙ and 1:85±0:04 R⊙.We find conclusive evidence of the presence of a third body orbiting V889 Aql with a period of 67 yr. Based on the detected third light and the absence of signal in the spectra, we suggest that this third body could in turn be a binary composed of two ±1.4 M⊙ stars. V402 Lac is composed of two stars with masses 2:80 ± 0:05 M⊙ and 2:78 ± 0:05 M⊙ and radii 2:38 ± 0:03 R⊙ and 2:36 ± 0:03 R⊙. The times of minimum light are compatible with the presence of a third body for this system too, although its period is not yet fully sampled. In both cases we have found a good agreement between the observed apsidal motion rates and the model predictions

Gene Co-expression Analysis Identifies Histone Deacetylase 5 and 9 Expression in Midbrain Dopamine Neurons and as Regulators of Neurite Growth via Bone Morphogenetic Protein Signaling

Parkinson’s disease is characterized by the intracellular accumulation of α-synuclein which has been linked to early dopaminergic axonal degeneration. Identifying druggable targets that can promote axonal growth in cells overexpressing α-synuclein is important in order to develop strategies for early intervention. Class-IIa histone deacetylases (HDACs) have previously emerged as druggable targets, however, it is not known which specific class-IIa HDACs should be targeted to promote neurite growth in dopaminergic neurons. To provide insight into this, we used gene co-expression analysis to identify which, if any, of the class-IIa HDACs had a positive correlation with markers of dopaminergic neurons in the human substantia nigra. This revealed that two histone deacetylases, HDAC5 and HDAC9, are co-expressed with TH, GIRK2 and ALDH1A1 in the human SN. We further found that HDAC5 and HDAC9 are expressed in dopaminergic neurons in the adult mouse substantia nigra. We show that siRNAs targeting HDAC5 or HDAC9 can promote neurite growth in SH-SY5Y cells, and that their pharmacological inhibition, using the drug MC1568, promoted neurite growth in cultured rat dopaminergic neurons. Moreover, MC1568 treatment upregulated the expression of the neurotrophic factor, BMP2, and its downstream transcription factor, SMAD1. In addition, MC1568 or siRNAs targeting HDAC5 or HDAC9 led to an increase in Smad-dependent GFP expression in a reporter assay. Furthermore, MC1568 treatment of cultured rat dopaminergic neurons increased cellular levels of phosphorylated Smad1, which was prevented by the BMP receptor inhibitor, dorsomorphin. Dorsomorphin treatment prevented the neurite growth-promoting effects of siRNAs targeting HDAC5, as did overexpression of dominant-negative Smad4 or of the inhibitory Smad7, demonstrating a functional link to BMP signaling. Supplementation with BMP2 prevented the neurite growth-inhibitory effects of nuclear-restricted HDAC5. Finally, we report that siRNAs targeting HDAC5 or HDAC9 promoted neurite growth in cells overexpressing wild-type or A53T-α-synuclein and that MC1568 protected cultured rat dopaminergic neurons against the neurotoxin, MPP+. These findings establish HDAC5 and HDAC9 as novel regulators of BMP-Smad signaling, that additionally may be therapeutic targets worthy of further exploration in iPSC-derived human DA neurons and in vivo models of Parkinson’s disease

In-situ study of the carbon gasification reaction of highly oriented pyrolytic graphite promoted by cobalt oxides and the novel nanostructures appeared after reaction

Cobalt interaction and its effects on carbon-based systems at the nanoscale have recently attracted much attention in different fields, such as catalysis of carbon nanotubes or graphene and graphite nano-patterning taking advantage of its ferromagnetic behavior. Experiments performed in our laboratories show how the re-oxidation process of two equivalent monolayers of CoO deposited on highly oriented pyrolytic graphite at 400 °C leads to the formation of nanochannels at lower temperature than using other methods. Here we present the in-situ characterization of the carbon gasification reaction that drives this process by means of near ambient pressure X-ray photoelectron spectroscopy performed at the ALBA synchrotron facility. The reason why this reaction takes place at such low temperature compared to other methods is due to the weakening of the carbon σ bonds by the initial CoO wetting layer formed at the early stages of growth on the graphite surface. Besides nanochannels, ex-situ atomic force microscopy measurements also show the appearance of two more kinds of nanostructures: nano-strips and nano-rings. The appearance of these nanostructures reveals the impressive modification of the surface after the re-oxidation process mediated by the cobalt oxideThis investigation has been funded by the MINECO of Spain through the FIS2015-67367-C2-1-P P and MAT2017-85089-C2-1-R projects and by the Comunidad de Madrid through the NANOMAGCOST-CM Ref: P2018/NMT4321 project. The experiments were performed at CIRCE/NAPP beamline at ALBA Synchrotron with the collaboration of ALBA staff. Work at the Molecular Foundry was supported by the Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy under Contract No. DE-AC02-05CH1123

Massive stars exploding in a He-rich circumstellar medium. V. Observations of the slow-evolving SN Ibn OGLE-2012-SN-006

We present optical observations of the peculiar Type Ibn supernova (SN Ibn) OGLE-2012-SN-006, discovered and monitored by the OGLE-IV survey, and spectroscopically followed by PESSTO at late phases. Stringent pre-discovery limits constrain the explosion epoch with fair precision to JD = 2456203.8 +- 4.0. The rise time to the I-band light curve maximum is about two weeks. The object reaches the peak absolute magnitude M(I) = -19.65 +- 0.19 on JD = 2456218.1 +- 1.8. After maximum, the light curve declines for about 25 days with a rate of 4 mag per 100d. The symmetric I-band peak resembles that of canonical Type Ib/c supernovae (SNe), whereas SNe Ibn usually exhibit asymmetric and narrower early-time light curves. Since 25 days past maximum, the light curve flattens with a decline rate slower than that of the 56Co to 56Fe decay, although at very late phases it steepens to approach that rate. An early-time spectrum is dominated by a blue continuum, with only a marginal evidence for the presence of He I lines marking this SN Type. This spectrum shows broad absorptions bluewards than 5000A, likely O II lines, which are similar to spectral features observed in super-luminous SNe at early epochs. The object has been spectroscopically monitored by PESSTO from 90 to 180 days after peak, and these spectra show the typical features observed in a number of SN 2006jc-like events, including a blue spectral energy distribution and prominent and narrow (v(FWHM) ~ 1900 km/s) He I emission lines. This suggests that the ejecta are interacting with He-rich circumstellar material. The detection of broad (10000 km/s) O I and Ca II features likely produced in the SN ejecta (including the [O I] 6300A,6364A doublet in the latest spectra) lends support to the interpretation of OGLE-2012-SN-006 as a core-collapse event.Comment: 16 pages, 9 figures, 4 tables. Accepted by MNRA

Syncytiotrophoblast derived extracellular vesicles transfer functional placental miRNAs to primary human endothelial cells

During the pregnancy associated syndrome preeclampsia (PE), there is increased release of placental syncytiotrophoblast extracellular vesicles (STBEVs) and free foetal haemoglobin (HbF) into the maternal circulation. In the present study we investigated the uptake of normal and PE STBEVs by primary human coronary artery endothelial cells (HCAEC) and the effects of free HbF on this uptake. Our results show internalization of STBEVs into primary HCAEC, and transfer of placenta specific miRNAs from STBEVs into the endoplasmic reticulum and mitochondria of these recipient cells. Further, the transferred miRNAs were functional, causing a down regulation of specific target genes, including the PE associated gene fms related tyrosine kinase 1 (FLT1). When co-treating normal STBEVs with HbF, the miRNA deposition is altered from the mitochondria to the ER and the cell membrane becomes ruffled, as was also seen with PE STBEVs. These findings suggest that STBEVs may cause endothelial damage and contribute to the endothelial dysfunction typical for PE. The miRNA mediated effects on gene expression may contribute to the oxidative and endoplasmic reticulum stress described in PE, as well as endothelial reprogramming that may underlay the increased risk of cardiovascular disease reported for women with PE later in life

A Significantly off-center Ni56 Distribution for the Low-Luminosity Type Ia Supernova SN 2016brx from the 100IAS survey

We present nebular-phase spectra of the Type Ia supernova (SN Ia) 2016brx, a member of the 1991bg-like subclass that lies at the faint end of the SN Ia luminosity function. Nebular spectra are available for only three other 1991bg-like SNe, and their Co line centers are all within <~ 500 km/s of each other. In contrast, the nebular Co line center of SN 2016brx is blue-shifted by >1500 km/s compared to them and by ~1200 km/s compared to the rest frame. This is a significant shift relative to the narrow nebular line velocity dispersion of <~ 2000 km/s of these SNe. The large range of nebular line shifts implies that the Ni56 in the ejecta of SN 1991bg-like events is off-center by ~1000 km/s rather than universally centrally confined as previously suggested. With the addition of SN 2016brx, the Co nebular line shapes of 1991bg-like objects appear to connect with the brighter SNe Ia that show double-peak profiles, hinting at a continuous distribution of line profiles among SNe Ia. One class of models to produce both off-center and bi-modal Ni56 distributions is collisions of white dwarfs with unequal and equal masses.Comment: Minor Changes. Accepted by MNRAS Lette

Research priorities for maintaining biodiversity’s contributions to people in Latin America

Maintaining biodiversity is crucial for ensuring human well-being. The authors participated in a workshop held in Palenque, Mexico, in August 2018, that brought together 30 mostly early-career scientists working in different disciplines (natural, social and economic sciences) with the aim of identifying research priorities for studying the contributions of biodiversity to people and how these contributions might be impacted by environmental change. Five main groups of questions emerged: (1) Enhancing the quantity, quality, and availability of biodiversity data; (2) Integrating different knowledge systems; (3) Improved methods for integrating diverse data; (4) Fundamental questions in ecology and evolution; and (5) Multi-level governance across boundaries. We discuss the need for increased capacity building and investment in research programmes to address these challenges

HII Region Metallicity Constraints Near the Site of the Strongly Lensed Supernova "SN Refsdal" at Redshift 1.49

T. Yuan, C. Kobayashi, and L. J. Kewley, “HII Region Metallicity Constraints Near the Site of the Strongly Lensed Supernova "SN Refsdal" at Redshift 1.49”, The Astrophysical Journal Letters, Vol. 804(1), April 2015. © 2015. The American Astronomical Society.We present the local HII region metallicity near the site of the recently discovered multiply lensed supernova (SN; "SN Refsdal") at redshift 1.49. "SN Refsdal" is located at the outer spiral arm ($\sim$7 kpc) of the lensed host galaxy, which we have previously reported to exhibit a steep negative galactocentric metallicity gradient. Based on our updated near-infrared integral field spectroscopic data, the gas-phase metallicity averaged in an intrinsic radius of $\sim$ 550 pc surrounding an HII region $\sim$ 200 pc away from the SN site is 12 + log(O/H)$_{\rm PP04N2}$ $\le$ 8.67. The metallicity averaged over nine HII regions at similar galactocentric distances ($\sim$5-7 kpc) as "SN Refsdal" is constrained to be 12 + log(O/H)$_{\rm PP04N2}$ $\le$ 8.11. Given the fortuitous discovery of "SN Refsdal" in an advantageously lensed face-on spiral, this is the first observational constraint on the local metallicity environment of an SN site at redshift $z>1$.Peer reviewe

Adaptation and Preadaptation of Salmonella enterica to Bile

Bile possesses antibacterial activity because bile salts disrupt membranes, denature proteins, and damage DNA. This study describes mechanisms employed by the bacterium Salmonella enterica to survive bile. Sublethal concentrations of the bile salt sodium deoxycholate (DOC) adapt Salmonella to survive lethal concentrations of bile. Adaptation seems to be associated to multiple changes in gene expression, which include upregulation of the RpoS-dependent general stress response and other stress responses. The crucial role of the general stress response in adaptation to bile is supported by the observation that RpoS− mutants are bile-sensitive. While adaptation to bile involves a response by the bacterial population, individual cells can become bile-resistant without adaptation: plating of a non-adapted S. enterica culture on medium containing a lethal concentration of bile yields bile-resistant colonies at frequencies between 10−6 and 10−7 per cell and generation. Fluctuation analysis indicates that such colonies derive from bile-resistant cells present in the previous culture. A fraction of such isolates are stable, indicating that bile resistance can be acquired by mutation. Full genome sequencing of bile-resistant mutants shows that alteration of the lipopolysaccharide transport machinery is a frequent cause of mutational bile resistance. However, selection on lethal concentrations of bile also provides bile-resistant isolates that are not mutants. We propose that such isolates derive from rare cells whose physiological state permitted survival upon encountering bile. This view is supported by single cell analysis of gene expression using a microscope fluidic system: batch cultures of Salmonella contain cells that activate stress response genes in the absence of DOC. This phenomenon underscores the existence of phenotypic heterogeneity in clonal populations of bacteria and may illustrate the adaptive value of gene expression fluctuations

The Dark Energy Spectroscopic Instrument (DESI)

We present the status of the Dark Energy Spectroscopic Instrument (DESI) and its plans and opportunities for the coming decade. DESI construction and its initial five years of operations are an approved experiment of the US Department of Energy and is summarized here as context for the Astro2020 panel. Beyond 2025, DESI will require new funding to continue operations. We expect that DESI will remain one of the world's best facilities for wide-field spectroscopy throughout the decade. More about the DESI instrument and survey can be found at https://www.desi.lbl.gov